The impact of Toxoplasma gondii on the mammalian genome

Detalhes bibliográficos
Autor(a) principal: Müller, Urs B
Data de Publicação: 2016
Outros Autores: Howard, Jonathan C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/933
Resumo: Nobody doubts that infections have imposed specialisations on the mammalian genome. However sufficient information is usually missing to attribute a specific genomic modification to pressure from a specific pathogen. Recent studies on mechanisms of mammalian resistance against the ubiquitous protozoan parasite, Toxoplasma gondii, have shown that the small rodents presumed to be largely responsible for transmission of the parasite to its definitive host, the domestic cat, possess distinctive recognition proteins, and interferon-inducible effector proteins (IRG proteins) that limit the potential virulence of the parasite. The phylogenetic association of the recognition proteins, TLR11 and TLR12, with T. gondii resistance is weak, but there is evidence for reciprocal polymorphism between parasite virulence proteins and host IRG proteins that strongly suggests current or recent coevolution.
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spelling The impact of Toxoplasma gondii on the mammalian genomeAnimalsCatsGenomeHost-Pathogen InteractionsHumansHydro-LyasesMiceToll-Like ReceptorsToxoplasmaToxoplasmosisVirulenceNobody doubts that infections have imposed specialisations on the mammalian genome. However sufficient information is usually missing to attribute a specific genomic modification to pressure from a specific pathogen. Recent studies on mechanisms of mammalian resistance against the ubiquitous protozoan parasite, Toxoplasma gondii, have shown that the small rodents presumed to be largely responsible for transmission of the parasite to its definitive host, the domestic cat, possess distinctive recognition proteins, and interferon-inducible effector proteins (IRG proteins) that limit the potential virulence of the parasite. The phylogenetic association of the recognition proteins, TLR11 and TLR12, with T. gondii resistance is weak, but there is evidence for reciprocal polymorphism between parasite virulence proteins and host IRG proteins that strongly suggests current or recent coevolution.ARCAMüller, Urs BHoward, Jonathan C2020-03-11T11:43:30Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/933engMüller UB, Howard JC. The impact of Toxoplasma gondii on the mammalian genome. Curr Opin Microbiol. 2016;32:19–2510.1016/j.mib.2016.04.009info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:21Zoai:arca.igc.gulbenkian.pt:10400.7/933Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:08.134122Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The impact of Toxoplasma gondii on the mammalian genome
title The impact of Toxoplasma gondii on the mammalian genome
spellingShingle The impact of Toxoplasma gondii on the mammalian genome
Müller, Urs B
Animals
Cats
Genome
Host-Pathogen Interactions
Humans
Hydro-Lyases
Mice
Toll-Like Receptors
Toxoplasma
Toxoplasmosis
Virulence
title_short The impact of Toxoplasma gondii on the mammalian genome
title_full The impact of Toxoplasma gondii on the mammalian genome
title_fullStr The impact of Toxoplasma gondii on the mammalian genome
title_full_unstemmed The impact of Toxoplasma gondii on the mammalian genome
title_sort The impact of Toxoplasma gondii on the mammalian genome
author Müller, Urs B
author_facet Müller, Urs B
Howard, Jonathan C
author_role author
author2 Howard, Jonathan C
author2_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Müller, Urs B
Howard, Jonathan C
dc.subject.por.fl_str_mv Animals
Cats
Genome
Host-Pathogen Interactions
Humans
Hydro-Lyases
Mice
Toll-Like Receptors
Toxoplasma
Toxoplasmosis
Virulence
topic Animals
Cats
Genome
Host-Pathogen Interactions
Humans
Hydro-Lyases
Mice
Toll-Like Receptors
Toxoplasma
Toxoplasmosis
Virulence
description Nobody doubts that infections have imposed specialisations on the mammalian genome. However sufficient information is usually missing to attribute a specific genomic modification to pressure from a specific pathogen. Recent studies on mechanisms of mammalian resistance against the ubiquitous protozoan parasite, Toxoplasma gondii, have shown that the small rodents presumed to be largely responsible for transmission of the parasite to its definitive host, the domestic cat, possess distinctive recognition proteins, and interferon-inducible effector proteins (IRG proteins) that limit the potential virulence of the parasite. The phylogenetic association of the recognition proteins, TLR11 and TLR12, with T. gondii resistance is weak, but there is evidence for reciprocal polymorphism between parasite virulence proteins and host IRG proteins that strongly suggests current or recent coevolution.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2020-03-11T11:43:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/933
url http://hdl.handle.net/10400.7/933
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Müller UB, Howard JC. The impact of Toxoplasma gondii on the mammalian genome. Curr Opin Microbiol. 2016;32:19–25
10.1016/j.mib.2016.04.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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