Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/4118 |
Resumo: | Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are com monly used for testing close paternal relationships among individuals and populations, and for male lineage iden tification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strik ingly, >99% of the 12,272 unrelated males were com pletely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost ab sent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in ur ban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and over all male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. |
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Toward male individualization with rapidly mutating y‐chromosomal short tandem repeatsY-chromosomeY-STRsHaplotypesRM YSTRsPaternal lineageForensic.Faculdade de Ciências da VidaRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are com monly used for testing close paternal relationships among individuals and populations, and for male lineage iden tification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strik ingly, >99% of the 12,272 unrelated males were com pletely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost ab sent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in ur ban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and over all male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.WileyDigitUMaBallantyne, Kaye N.Ralf, ArwinAboukhalid, RachidAchakzai, Niaz M.Anjos, Maria J.Ayub, QasimBalažic, JožeBallantyne, JackBallard, David J.Berger, BurkhardBobillo, CeciliaBouabdellah, MehdiBurri, HelenCapal, TomasCaratti, StefanoCárdenas, JorgeCartault, FrançoisCarvalho, Elizeu F.Carvalho, MonicaCheng, BaowenCoble, Michael D.Comas, DavidCorach, DanielD'Amato, Maria E.Davison, Seande Knijff, PeterDe Ungria, Maria Corazon A.Decorte, RonnyDobosz, TadeuszDupuy, Berit M.Elmrghni, SamirGliwiński, MateuszGomes, Sara C.Grol, LaurensHaas, CordulaHanson, ErinHenke, JürgenHenke, LotteHerrera-Rodríguez, FabiolaHill, Carolyn R.Holmlund, GunillaHonda, KatsuyaImmel, Uta-DorotheeInokuchi, ShotaJobling, Mark A.Kaddura, MahmoudKim, Jong S.Kim, Soon H.Kim, WookKing, Turi E.Klausriegler, EvaKling, DanielKovačević, LejlaKovatsi, LedaKrajewski, PawełKravchenko, SergeyLarmuseau, Maarten H. D.Lee, Eun YoungLessig, RuedigerLivshits, Ludmila A.Marjanović, DamirMinarik, MarekMizuno, NatsukoMoreira, HelenaMorling, NielsMukherjee, MeetaMunier, PatrickNagaraju, JavaregowdaNeuhuber, FranzNie, ShengjieNilasitsataporn, PremlaphatNishi, TakekiOh, Hye H.Olofsson, JillOnofri, ValerioPalo, Jukka U.Pamjav, HorolmaParson, WaltherPetlach, MichalPhillips, ChristopherPloski, RafalPrasad, Samayamantri P. R.Primorac, DraganPurnomo, Gludhug A.Purps, JosephineRangel-Villalobos, HectorRębała, KrzysztofRerkamnuaychoke, BudsabaGonzalez, Danel ReyRobino, CarloRoewer, LutzRosa, AlexandraSajantila, AnttiSala, AndreaSalvador, Jazelyn M.Sanz, PaulaSchmitt, CorneliaSharma, Anil K.Silva, Dayse A.Shin, Kyoung-JinSijen, TitiaSirker, MiriamSiváková, DanielaŠkaro, VedranaSolano-Matamoros, CarlosSouto, LuisStenzl, VlastimilSudoyo, HerawatiSyndercombe-Court, DeniseTagliabracci, AdrianoTaylor, DuncanTillmar, AndreasTsybovsky, Iosif S.Tyler-Smith, Chrisvan der Gaag, Kristiaan J.Vanek, DanielVölgyi, AntóniaWard, DeniseWillemse, PatriciaYap, Eric P.H.Yong, Rita Y.Y.Pajnič, Irena ZupaničKayser, Manfred2022-03-07T11:26:04Z2014-01-01T00:00:00Z2014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/4118engBallantyne, K. N., Ralf, A., Aboukhalid, R., Achakzai, N. M., Anjos, M. J., Ayub, Q., ... & Kayser, M. (2014). Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats. https://doi.org/10.1002/humu.22599, 35(8), 1021-1032. https://doi.org/10.1002/humu.2259910.1002/humu.22599info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:57:18Zoai:digituma.uma.pt:10400.13/4118Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:07:56.832281Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
title |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
spellingShingle |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats Ballantyne, Kaye N. Y-chromosome Y-STRs Haplotypes RM YSTRs Paternal lineage Forensic . Faculdade de Ciências da Vida |
title_short |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
title_full |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
title_fullStr |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
title_full_unstemmed |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
title_sort |
Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats |
author |
Ballantyne, Kaye N. |
author_facet |
Ballantyne, Kaye N. Ralf, Arwin Aboukhalid, Rachid Achakzai, Niaz M. Anjos, Maria J. Ayub, Qasim Balažic, Jože Ballantyne, Jack Ballard, David J. Berger, Burkhard Bobillo, Cecilia Bouabdellah, Mehdi Burri, Helen Capal, Tomas Caratti, Stefano Cárdenas, Jorge Cartault, François Carvalho, Elizeu F. Carvalho, Monica Cheng, Baowen Coble, Michael D. Comas, David Corach, Daniel D'Amato, Maria E. Davison, Sean de Knijff, Peter De Ungria, Maria Corazon A. Decorte, Ronny Dobosz, Tadeusz Dupuy, Berit M. Elmrghni, Samir Gliwiński, Mateusz Gomes, Sara C. Grol, Laurens Haas, Cordula Hanson, Erin Henke, Jürgen Henke, Lotte Herrera-Rodríguez, Fabiola Hill, Carolyn R. Holmlund, Gunilla Honda, Katsuya Immel, Uta-Dorothee Inokuchi, Shota Jobling, Mark A. Kaddura, Mahmoud Kim, Jong S. Kim, Soon H. Kim, Wook King, Turi E. Klausriegler, Eva Kling, Daniel Kovačević, Lejla Kovatsi, Leda Krajewski, Paweł Kravchenko, Sergey Larmuseau, Maarten H. D. Lee, Eun Young Lessig, Ruediger Livshits, Ludmila A. Marjanović, Damir Minarik, Marek Mizuno, Natsuko Moreira, Helena Morling, Niels Mukherjee, Meeta Munier, Patrick Nagaraju, Javaregowda Neuhuber, Franz Nie, Shengjie Nilasitsataporn, Premlaphat Nishi, Takeki Oh, Hye H. Olofsson, Jill Onofri, Valerio Palo, Jukka U. Pamjav, Horolma Parson, Walther Petlach, Michal Phillips, Christopher Ploski, Rafal Prasad, Samayamantri P. R. Primorac, Dragan Purnomo, Gludhug A. Purps, Josephine Rangel-Villalobos, Hector Rębała, Krzysztof Rerkamnuaychoke, Budsaba Gonzalez, Danel Rey Robino, Carlo Roewer, Lutz Rosa, Alexandra Sajantila, Antti Sala, Andrea Salvador, Jazelyn M. Sanz, Paula Schmitt, Cornelia Sharma, Anil K. Silva, Dayse A. Shin, Kyoung-Jin Sijen, Titia Sirker, Miriam Siváková, Daniela Škaro, Vedrana Solano-Matamoros, Carlos Souto, Luis Stenzl, Vlastimil Sudoyo, Herawati Syndercombe-Court, Denise Tagliabracci, Adriano Taylor, Duncan Tillmar, Andreas Tsybovsky, Iosif S. Tyler-Smith, Chris van der Gaag, Kristiaan J. Vanek, Daniel Völgyi, Antónia Ward, Denise Willemse, Patricia Yap, Eric P.H. Yong, Rita Y.Y. Pajnič, Irena Zupanič Kayser, Manfred |
author_role |
author |
author2 |
Ralf, Arwin Aboukhalid, Rachid Achakzai, Niaz M. Anjos, Maria J. Ayub, Qasim Balažic, Jože Ballantyne, Jack Ballard, David J. Berger, Burkhard Bobillo, Cecilia Bouabdellah, Mehdi Burri, Helen Capal, Tomas Caratti, Stefano Cárdenas, Jorge Cartault, François Carvalho, Elizeu F. Carvalho, Monica Cheng, Baowen Coble, Michael D. Comas, David Corach, Daniel D'Amato, Maria E. Davison, Sean de Knijff, Peter De Ungria, Maria Corazon A. Decorte, Ronny Dobosz, Tadeusz Dupuy, Berit M. Elmrghni, Samir Gliwiński, Mateusz Gomes, Sara C. Grol, Laurens Haas, Cordula Hanson, Erin Henke, Jürgen Henke, Lotte Herrera-Rodríguez, Fabiola Hill, Carolyn R. Holmlund, Gunilla Honda, Katsuya Immel, Uta-Dorothee Inokuchi, Shota Jobling, Mark A. Kaddura, Mahmoud Kim, Jong S. Kim, Soon H. Kim, Wook King, Turi E. Klausriegler, Eva Kling, Daniel Kovačević, Lejla Kovatsi, Leda Krajewski, Paweł Kravchenko, Sergey Larmuseau, Maarten H. D. Lee, Eun Young Lessig, Ruediger Livshits, Ludmila A. Marjanović, Damir Minarik, Marek Mizuno, Natsuko Moreira, Helena Morling, Niels Mukherjee, Meeta Munier, Patrick Nagaraju, Javaregowda Neuhuber, Franz Nie, Shengjie Nilasitsataporn, Premlaphat Nishi, Takeki Oh, Hye H. Olofsson, Jill Onofri, Valerio Palo, Jukka U. Pamjav, Horolma Parson, Walther Petlach, Michal Phillips, Christopher Ploski, Rafal Prasad, Samayamantri P. R. Primorac, Dragan Purnomo, Gludhug A. Purps, Josephine Rangel-Villalobos, Hector Rębała, Krzysztof Rerkamnuaychoke, Budsaba Gonzalez, Danel Rey Robino, Carlo Roewer, Lutz Rosa, Alexandra Sajantila, Antti Sala, Andrea Salvador, Jazelyn M. Sanz, Paula Schmitt, Cornelia Sharma, Anil K. Silva, Dayse A. Shin, Kyoung-Jin Sijen, Titia Sirker, Miriam Siváková, Daniela Škaro, Vedrana Solano-Matamoros, Carlos Souto, Luis Stenzl, Vlastimil Sudoyo, Herawati Syndercombe-Court, Denise Tagliabracci, Adriano Taylor, Duncan Tillmar, Andreas Tsybovsky, Iosif S. Tyler-Smith, Chris van der Gaag, Kristiaan J. Vanek, Daniel Völgyi, Antónia Ward, Denise Willemse, Patricia Yap, Eric P.H. Yong, Rita Y.Y. Pajnič, Irena Zupanič Kayser, Manfred |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Ballantyne, Kaye N. Ralf, Arwin Aboukhalid, Rachid Achakzai, Niaz M. Anjos, Maria J. Ayub, Qasim Balažic, Jože Ballantyne, Jack Ballard, David J. Berger, Burkhard Bobillo, Cecilia Bouabdellah, Mehdi Burri, Helen Capal, Tomas Caratti, Stefano Cárdenas, Jorge Cartault, François Carvalho, Elizeu F. Carvalho, Monica Cheng, Baowen Coble, Michael D. Comas, David Corach, Daniel D'Amato, Maria E. Davison, Sean de Knijff, Peter De Ungria, Maria Corazon A. Decorte, Ronny Dobosz, Tadeusz Dupuy, Berit M. Elmrghni, Samir Gliwiński, Mateusz Gomes, Sara C. Grol, Laurens Haas, Cordula Hanson, Erin Henke, Jürgen Henke, Lotte Herrera-Rodríguez, Fabiola Hill, Carolyn R. Holmlund, Gunilla Honda, Katsuya Immel, Uta-Dorothee Inokuchi, Shota Jobling, Mark A. Kaddura, Mahmoud Kim, Jong S. Kim, Soon H. Kim, Wook King, Turi E. Klausriegler, Eva Kling, Daniel Kovačević, Lejla Kovatsi, Leda Krajewski, Paweł Kravchenko, Sergey Larmuseau, Maarten H. D. Lee, Eun Young Lessig, Ruediger Livshits, Ludmila A. Marjanović, Damir Minarik, Marek Mizuno, Natsuko Moreira, Helena Morling, Niels Mukherjee, Meeta Munier, Patrick Nagaraju, Javaregowda Neuhuber, Franz Nie, Shengjie Nilasitsataporn, Premlaphat Nishi, Takeki Oh, Hye H. Olofsson, Jill Onofri, Valerio Palo, Jukka U. Pamjav, Horolma Parson, Walther Petlach, Michal Phillips, Christopher Ploski, Rafal Prasad, Samayamantri P. R. Primorac, Dragan Purnomo, Gludhug A. Purps, Josephine Rangel-Villalobos, Hector Rębała, Krzysztof Rerkamnuaychoke, Budsaba Gonzalez, Danel Rey Robino, Carlo Roewer, Lutz Rosa, Alexandra Sajantila, Antti Sala, Andrea Salvador, Jazelyn M. Sanz, Paula Schmitt, Cornelia Sharma, Anil K. Silva, Dayse A. Shin, Kyoung-Jin Sijen, Titia Sirker, Miriam Siváková, Daniela Škaro, Vedrana Solano-Matamoros, Carlos Souto, Luis Stenzl, Vlastimil Sudoyo, Herawati Syndercombe-Court, Denise Tagliabracci, Adriano Taylor, Duncan Tillmar, Andreas Tsybovsky, Iosif S. Tyler-Smith, Chris van der Gaag, Kristiaan J. Vanek, Daniel Völgyi, Antónia Ward, Denise Willemse, Patricia Yap, Eric P.H. Yong, Rita Y.Y. Pajnič, Irena Zupanič Kayser, Manfred |
dc.subject.por.fl_str_mv |
Y-chromosome Y-STRs Haplotypes RM YSTRs Paternal lineage Forensic . Faculdade de Ciências da Vida |
topic |
Y-chromosome Y-STRs Haplotypes RM YSTRs Paternal lineage Forensic . Faculdade de Ciências da Vida |
description |
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are com monly used for testing close paternal relationships among individuals and populations, and for male lineage iden tification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strik ingly, >99% of the 12,272 unrelated males were com pletely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost ab sent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in ur ban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and over all male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01T00:00:00Z 2014-01-01T00:00:00Z 2022-03-07T11:26:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/4118 |
url |
http://hdl.handle.net/10400.13/4118 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ballantyne, K. N., Ralf, A., Aboukhalid, R., Achakzai, N. M., Anjos, M. J., Ayub, Q., ... & Kayser, M. (2014). Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats. https://doi.org/10.1002/humu.22599, 35(8), 1021-1032. https://doi.org/10.1002/humu.22599 10.1002/humu.22599 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129947588001792 |