Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function

Bibliographic Details
Main Author: Silva, MIO
Publication Date: 2020
Other Authors: Liz, MA
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: https://hdl.handle.net/10216/143495
Summary: Alpha-Synuclein (aSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson’s disease. However, the consequences of aSyn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of this cytoskeleton component is emerging in neurodegenerative disorders, the impact of aSyn on actin is a critical point to be addressed. In this review we explore the link between aSyn and actin and its significance for physiology and pathology. We discuss the relevance of aSyn-actin interaction for synaptic function and highlight the actin-depolymerizing protein cofilin-1 as a key player on aSyn-induced actin dysfunction in Parkinson’s disease.
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spelling Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Functionactin cytoskeletonactin-binding proteinsalpha-Synucleincofilin-1Parkinson’s diseaseAlpha-Synuclein (aSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson’s disease. However, the consequences of aSyn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of this cytoskeleton component is emerging in neurodegenerative disorders, the impact of aSyn on actin is a critical point to be addressed. In this review we explore the link between aSyn and actin and its significance for physiology and pathology. We discuss the relevance of aSyn-actin interaction for synaptic function and highlight the actin-depolymerizing protein cofilin-1 as a key player on aSyn-induced actin dysfunction in Parkinson’s disease.Frontiers Media20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143495eng2296-634X10.3389/fcell.2020.00787Silva, MIOLiz, MAinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T16:00:15Zoai:repositorio-aberto.up.pt:10216/143495Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:36:26.722114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
title Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
spellingShingle Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
Silva, MIO
actin cytoskeleton
actin-binding proteins
alpha-Synuclein
cofilin-1
Parkinson’s disease
title_short Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
title_full Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
title_fullStr Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
title_full_unstemmed Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
title_sort Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function
author Silva, MIO
author_facet Silva, MIO
Liz, MA
author_role author
author2 Liz, MA
author2_role author
dc.contributor.author.fl_str_mv Silva, MIO
Liz, MA
dc.subject.por.fl_str_mv actin cytoskeleton
actin-binding proteins
alpha-Synuclein
cofilin-1
Parkinson’s disease
topic actin cytoskeleton
actin-binding proteins
alpha-Synuclein
cofilin-1
Parkinson’s disease
description Alpha-Synuclein (aSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson’s disease. However, the consequences of aSyn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of this cytoskeleton component is emerging in neurodegenerative disorders, the impact of aSyn on actin is a critical point to be addressed. In this review we explore the link between aSyn and actin and its significance for physiology and pathology. We discuss the relevance of aSyn-actin interaction for synaptic function and highlight the actin-depolymerizing protein cofilin-1 as a key player on aSyn-induced actin dysfunction in Parkinson’s disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/143495
url https://hdl.handle.net/10216/143495
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-634X
10.3389/fcell.2020.00787
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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