Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8274 https://doi.org/10.1002/elan.200603591 |
Resumo: | The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be DO=7.35×10-6 cm2 s-1 in pH 4.5 0.1 M acetate buffer. |
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Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of GlivecThe electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be DO=7.35×10-6 cm2 s-1 in pH 4.5 0.1 M acetate buffer.2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8274http://hdl.handle.net/10316/8274https://doi.org/10.1002/elan.200603591engElectroanalysis. 18:18 (2006) 1800-1807Diculescu, Victor ConstantinVivan, MarileneBrett, Ana Maria Oliveirainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-02-19T10:21:19Zoai:estudogeral.uc.pt:10316/8274Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:43.004238Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
title |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
spellingShingle |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec Diculescu, Victor Constantin |
title_short |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
title_full |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
title_fullStr |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
title_full_unstemmed |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
title_sort |
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec |
author |
Diculescu, Victor Constantin |
author_facet |
Diculescu, Victor Constantin Vivan, Marilene Brett, Ana Maria Oliveira |
author_role |
author |
author2 |
Vivan, Marilene Brett, Ana Maria Oliveira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Diculescu, Victor Constantin Vivan, Marilene Brett, Ana Maria Oliveira |
description |
The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be DO=7.35×10-6 cm2 s-1 in pH 4.5 0.1 M acetate buffer. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8274 http://hdl.handle.net/10316/8274 https://doi.org/10.1002/elan.200603591 |
url |
http://hdl.handle.net/10316/8274 https://doi.org/10.1002/elan.200603591 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Electroanalysis. 18:18 (2006) 1800-1807 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133907864518656 |