Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109721 https://doi.org/10.1186/1475-2840-12-61 |
Resumo: | Background: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications. |
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Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal womenDiabetesGenderHDL-c subpopulationsMarkers of cardiovascular riskMenopauseBlood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedPostmenopauseRisk FactorsWaist CircumferenceBody Mass IndexSex CharacteristicsBackground: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications.Springer Nature2013-04-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109721http://hdl.handle.net/10316/109721https://doi.org/10.1186/1475-2840-12-61eng1475-2840Melo, Filipa MascarenhasMarado, DanielaPalavra, FilipeSereno, JoséCoelho, ÁlvaroPinto, RuiLemos, Edite Teixeira deTeixeira, FredericoReis, Flávioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-24T10:12:40Zoai:estudogeral.uc.pt:10316/109721Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:52.478410Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
title |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
spellingShingle |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women Melo, Filipa Mascarenhas Diabetes Gender HDL-c subpopulations Markers of cardiovascular risk Menopause Blood Glucose Cardiovascular Diseases Diabetes Mellitus, Type 2 Female Humans Male Middle Aged Postmenopause Risk Factors Waist Circumference Body Mass Index Sex Characteristics |
title_short |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
title_full |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
title_fullStr |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
title_full_unstemmed |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
title_sort |
Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women |
author |
Melo, Filipa Mascarenhas |
author_facet |
Melo, Filipa Mascarenhas Marado, Daniela Palavra, Filipe Sereno, José Coelho, Álvaro Pinto, Rui Lemos, Edite Teixeira de Teixeira, Frederico Reis, Flávio |
author_role |
author |
author2 |
Marado, Daniela Palavra, Filipe Sereno, José Coelho, Álvaro Pinto, Rui Lemos, Edite Teixeira de Teixeira, Frederico Reis, Flávio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Filipa Mascarenhas Marado, Daniela Palavra, Filipe Sereno, José Coelho, Álvaro Pinto, Rui Lemos, Edite Teixeira de Teixeira, Frederico Reis, Flávio |
dc.subject.por.fl_str_mv |
Diabetes Gender HDL-c subpopulations Markers of cardiovascular risk Menopause Blood Glucose Cardiovascular Diseases Diabetes Mellitus, Type 2 Female Humans Male Middle Aged Postmenopause Risk Factors Waist Circumference Body Mass Index Sex Characteristics |
topic |
Diabetes Gender HDL-c subpopulations Markers of cardiovascular risk Menopause Blood Glucose Cardiovascular Diseases Diabetes Mellitus, Type 2 Female Humans Male Middle Aged Postmenopause Risk Factors Waist Circumference Body Mass Index Sex Characteristics |
description |
Background: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109721 http://hdl.handle.net/10316/109721 https://doi.org/10.1186/1475-2840-12-61 |
url |
http://hdl.handle.net/10316/109721 https://doi.org/10.1186/1475-2840-12-61 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1475-2840 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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