Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women

Detalhes bibliográficos
Autor(a) principal: Melo, Filipa Mascarenhas
Data de Publicação: 2013
Outros Autores: Marado, Daniela, Palavra, Filipe, Sereno, José, Coelho, Álvaro, Pinto, Rui, Lemos, Edite Teixeira de, Teixeira, Frederico, Reis, Flávio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109721
https://doi.org/10.1186/1475-2840-12-61
Resumo: Background: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications.
id RCAP_77124c225f0020fd25eb470e51768997
oai_identifier_str oai:estudogeral.uc.pt:10316/109721
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal womenDiabetesGenderHDL-c subpopulationsMarkers of cardiovascular riskMenopauseBlood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedPostmenopauseRisk FactorsWaist CircumferenceBody Mass IndexSex CharacteristicsBackground: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications.Springer Nature2013-04-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109721http://hdl.handle.net/10316/109721https://doi.org/10.1186/1475-2840-12-61eng1475-2840Melo, Filipa MascarenhasMarado, DanielaPalavra, FilipeSereno, JoséCoelho, ÁlvaroPinto, RuiLemos, Edite Teixeira deTeixeira, FredericoReis, Flávioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-24T10:12:40Zoai:estudogeral.uc.pt:10316/109721Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:52.478410Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
title Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
spellingShingle Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
Melo, Filipa Mascarenhas
Diabetes
Gender
HDL-c subpopulations
Markers of cardiovascular risk
Menopause
Blood Glucose
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Postmenopause
Risk Factors
Waist Circumference
Body Mass Index
Sex Characteristics
title_short Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
title_full Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
title_fullStr Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
title_full_unstemmed Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
title_sort Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
author Melo, Filipa Mascarenhas
author_facet Melo, Filipa Mascarenhas
Marado, Daniela
Palavra, Filipe
Sereno, José
Coelho, Álvaro
Pinto, Rui
Lemos, Edite Teixeira de
Teixeira, Frederico
Reis, Flávio
author_role author
author2 Marado, Daniela
Palavra, Filipe
Sereno, José
Coelho, Álvaro
Pinto, Rui
Lemos, Edite Teixeira de
Teixeira, Frederico
Reis, Flávio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo, Filipa Mascarenhas
Marado, Daniela
Palavra, Filipe
Sereno, José
Coelho, Álvaro
Pinto, Rui
Lemos, Edite Teixeira de
Teixeira, Frederico
Reis, Flávio
dc.subject.por.fl_str_mv Diabetes
Gender
HDL-c subpopulations
Markers of cardiovascular risk
Menopause
Blood Glucose
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Postmenopause
Risk Factors
Waist Circumference
Body Mass Index
Sex Characteristics
topic Diabetes
Gender
HDL-c subpopulations
Markers of cardiovascular risk
Menopause
Blood Glucose
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Postmenopause
Risk Factors
Waist Circumference
Body Mass Index
Sex Characteristics
description Background: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109721
http://hdl.handle.net/10316/109721
https://doi.org/10.1186/1475-2840-12-61
url http://hdl.handle.net/10316/109721
https://doi.org/10.1186/1475-2840-12-61
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1475-2840
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134140274049024