Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability

Detalhes bibliográficos
Autor(a) principal: Nunes, Ana R.
Data de Publicação: 2021
Outros Autores: Gonçalves, Ana C., Alves, Gilberto, Falcão, Amílcar, Garcia-Viguera, Cristina, A Moreno, Diego, Silva, Luís R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103952
https://doi.org/10.3390/foods10061185
Resumo: Prunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy.
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spelling Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells ViabilityPrunus avium L.by-productsphenolic compoundsantiproliferative propertiesPrunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy.MDPI2021-05-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103952http://hdl.handle.net/10316/103952https://doi.org/10.3390/foods10061185eng2304-8158Nunes, Ana R.Gonçalves, Ana C.Alves, GilbertoFalcão, AmílcarGarcia-Viguera, CristinaA Moreno, DiegoSilva, Luís Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-05T12:05:18Zoai:estudogeral.uc.pt:10316/103952Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:41.879062Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
title Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
spellingShingle Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
Nunes, Ana R.
Prunus avium L.
by-products
phenolic compounds
antiproliferative properties
title_short Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
title_full Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
title_fullStr Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
title_full_unstemmed Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
title_sort Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
author Nunes, Ana R.
author_facet Nunes, Ana R.
Gonçalves, Ana C.
Alves, Gilberto
Falcão, Amílcar
Garcia-Viguera, Cristina
A Moreno, Diego
Silva, Luís R
author_role author
author2 Gonçalves, Ana C.
Alves, Gilberto
Falcão, Amílcar
Garcia-Viguera, Cristina
A Moreno, Diego
Silva, Luís R
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Ana R.
Gonçalves, Ana C.
Alves, Gilberto
Falcão, Amílcar
Garcia-Viguera, Cristina
A Moreno, Diego
Silva, Luís R
dc.subject.por.fl_str_mv Prunus avium L.
by-products
phenolic compounds
antiproliferative properties
topic Prunus avium L.
by-products
phenolic compounds
antiproliferative properties
description Prunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-25
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103952
http://hdl.handle.net/10316/103952
https://doi.org/10.3390/foods10061185
url http://hdl.handle.net/10316/103952
https://doi.org/10.3390/foods10061185
dc.language.iso.fl_str_mv eng
language eng
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