Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103952 https://doi.org/10.3390/foods10061185 |
Resumo: | Prunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy. |
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Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells ViabilityPrunus avium L.by-productsphenolic compoundsantiproliferative propertiesPrunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy.MDPI2021-05-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103952http://hdl.handle.net/10316/103952https://doi.org/10.3390/foods10061185eng2304-8158Nunes, Ana R.Gonçalves, Ana C.Alves, GilbertoFalcão, AmílcarGarcia-Viguera, CristinaA Moreno, DiegoSilva, Luís Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-05T12:05:18Zoai:estudogeral.uc.pt:10316/103952Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:41.879062Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
title |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
spellingShingle |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability Nunes, Ana R. Prunus avium L. by-products phenolic compounds antiproliferative properties |
title_short |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
title_full |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
title_fullStr |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
title_full_unstemmed |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
title_sort |
Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability |
author |
Nunes, Ana R. |
author_facet |
Nunes, Ana R. Gonçalves, Ana C. Alves, Gilberto Falcão, Amílcar Garcia-Viguera, Cristina A Moreno, Diego Silva, Luís R |
author_role |
author |
author2 |
Gonçalves, Ana C. Alves, Gilberto Falcão, Amílcar Garcia-Viguera, Cristina A Moreno, Diego Silva, Luís R |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes, Ana R. Gonçalves, Ana C. Alves, Gilberto Falcão, Amílcar Garcia-Viguera, Cristina A Moreno, Diego Silva, Luís R |
dc.subject.por.fl_str_mv |
Prunus avium L. by-products phenolic compounds antiproliferative properties |
topic |
Prunus avium L. by-products phenolic compounds antiproliferative properties |
description |
Prunus avium L. by-products, such as stems, leaves, and flowers, are used in folk medicine to prevent and treat some diseases. However, their phenolic composition and in vitro bioactivities against tumor cells are poorly known. In this work, we compared the phenolic profile and the biological potential of aqueous infusions and hydroethanolic extracts of P. avium leaves, stems, and flowers from Saco cultivar, collected from the Fundão region (Portugal). Among the fifty-two phenolic compounds tentatively identified by HPLC-DAD-ESI/MSn, the hydroxycinnamic acids were the most abundant. Both extracts of stems revealed a higher activity against DPPH•. Meanwhile, hydroethanolic extracts from stems and flowers and aqueous infusions of flowers were the most effective in inhibiting the growth of the human epithelial colorectal adenocarcinoma (Caco-2) cells at concentrations above 200 μg/mL. More detailed knowledge about the phenolic composition and health-promoting properties of Portuguese P. avium by-products allows for increasing the biological and commercial value of these bio-wastes, which may have a positive impact on food and pharmaceutical industries, as on the valorization of the local economy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103952 http://hdl.handle.net/10316/103952 https://doi.org/10.3390/foods10061185 |
url |
http://hdl.handle.net/10316/103952 https://doi.org/10.3390/foods10061185 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2304-8158 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134099134218240 |