Obesity and the risk of cryptogenic ischemic stroke in young adults
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/52648 |
Resumo: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Obesity and the risk of cryptogenic ischemic stroke in young adultsCryptogenic strokeIschemic strokeObesityWaist-to-hip ratioYoung adults© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors.The study was funded by the Helsinki and Uusimaa Hospital District, Academy of Finland, University of Helsinki, and Sahlgrenska University Hospital.ElsevierRepositório da Universidade de LisboaJaakonmäki, NinaZedde, MarialuisaSarkanen, TomiMartinez-Majander, NicolasTuohinen, SuviSinisalo, JuhaRyödi, EssiAutere, JaanaHedman, MarjaJunttola, UllaHuhtakangas, Jaana K.Grimaldi, TeresaPascarella, RosarioNordanstig, AnnikaBech-Hanssen, OddHolbe, ChristineBusch, RailaFromm, AnnetteYlikotila, PauliTurgut, Esme EkizogluAmorim, IsabelRyliskiene, KristinaTulkki, LauriPascasio, Laura AmayaLicenik, RadimFerdinand, PhillipTsivgoulis, GeorgiosJatužis, DaliusKõrv, LiisaKõrv, JanikaPezzini, AlessandroFonseca, Ana CatarinaYesilot, NiluferRoine, Risto O.Waje-Andreassen, Ulrikevon Sarnowski, BettinaRedfors, PetraHuhtakangas, JuhaNumminen, HeikkiJäkälä, PekkaPutaala, Jukka2022-05-03T13:38:02Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52648engJ Stroke Cerebrovasc Dis. 2022 May;31(5):1063801052-305710.1016/j.jstrokecerebrovasdis.2022.1063801532-8511info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:56Zoai:repositorio.ul.pt:10451/52648Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:41.835454Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| title |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| spellingShingle |
Obesity and the risk of cryptogenic ischemic stroke in young adults Jaakonmäki, Nina Cryptogenic stroke Ischemic stroke Obesity Waist-to-hip ratio Young adults |
| title_short |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| title_full |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| title_fullStr |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| title_full_unstemmed |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| title_sort |
Obesity and the risk of cryptogenic ischemic stroke in young adults |
| author |
Jaakonmäki, Nina |
| author_facet |
Jaakonmäki, Nina Zedde, Marialuisa Sarkanen, Tomi Martinez-Majander, Nicolas Tuohinen, Suvi Sinisalo, Juha Ryödi, Essi Autere, Jaana Hedman, Marja Junttola, Ulla Huhtakangas, Jaana K. Grimaldi, Teresa Pascarella, Rosario Nordanstig, Annika Bech-Hanssen, Odd Holbe, Christine Busch, Raila Fromm, Annette Ylikotila, Pauli Turgut, Esme Ekizoglu Amorim, Isabel Ryliskiene, Kristina Tulkki, Lauri Pascasio, Laura Amaya Licenik, Radim Ferdinand, Phillip Tsivgoulis, Georgios Jatužis, Dalius Kõrv, Liisa Kõrv, Janika Pezzini, Alessandro Fonseca, Ana Catarina Yesilot, Nilufer Roine, Risto O. Waje-Andreassen, Ulrike von Sarnowski, Bettina Redfors, Petra Huhtakangas, Juha Numminen, Heikki Jäkälä, Pekka Putaala, Jukka |
| author_role |
author |
| author2 |
Zedde, Marialuisa Sarkanen, Tomi Martinez-Majander, Nicolas Tuohinen, Suvi Sinisalo, Juha Ryödi, Essi Autere, Jaana Hedman, Marja Junttola, Ulla Huhtakangas, Jaana K. Grimaldi, Teresa Pascarella, Rosario Nordanstig, Annika Bech-Hanssen, Odd Holbe, Christine Busch, Raila Fromm, Annette Ylikotila, Pauli Turgut, Esme Ekizoglu Amorim, Isabel Ryliskiene, Kristina Tulkki, Lauri Pascasio, Laura Amaya Licenik, Radim Ferdinand, Phillip Tsivgoulis, Georgios Jatužis, Dalius Kõrv, Liisa Kõrv, Janika Pezzini, Alessandro Fonseca, Ana Catarina Yesilot, Nilufer Roine, Risto O. Waje-Andreassen, Ulrike von Sarnowski, Bettina Redfors, Petra Huhtakangas, Juha Numminen, Heikki Jäkälä, Pekka Putaala, Jukka |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Jaakonmäki, Nina Zedde, Marialuisa Sarkanen, Tomi Martinez-Majander, Nicolas Tuohinen, Suvi Sinisalo, Juha Ryödi, Essi Autere, Jaana Hedman, Marja Junttola, Ulla Huhtakangas, Jaana K. Grimaldi, Teresa Pascarella, Rosario Nordanstig, Annika Bech-Hanssen, Odd Holbe, Christine Busch, Raila Fromm, Annette Ylikotila, Pauli Turgut, Esme Ekizoglu Amorim, Isabel Ryliskiene, Kristina Tulkki, Lauri Pascasio, Laura Amaya Licenik, Radim Ferdinand, Phillip Tsivgoulis, Georgios Jatužis, Dalius Kõrv, Liisa Kõrv, Janika Pezzini, Alessandro Fonseca, Ana Catarina Yesilot, Nilufer Roine, Risto O. Waje-Andreassen, Ulrike von Sarnowski, Bettina Redfors, Petra Huhtakangas, Juha Numminen, Heikki Jäkälä, Pekka Putaala, Jukka |
| dc.subject.por.fl_str_mv |
Cryptogenic stroke Ischemic stroke Obesity Waist-to-hip ratio Young adults |
| topic |
Cryptogenic stroke Ischemic stroke Obesity Waist-to-hip ratio Young adults |
| description |
© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05-03T13:38:02Z 2022 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/52648 |
| url |
http://hdl.handle.net/10451/52648 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
J Stroke Cerebrovasc Dis. 2022 May;31(5):106380 1052-3057 10.1016/j.jstrokecerebrovasdis.2022.106380 1532-8511 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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