Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/36863 |
Resumo: | The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products. |
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Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospectingAnti-inflammatoryBio-availabilityCancerLycopeneNanostructureThe purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products.Veritati - Repositório Institucional da Universidade Católica PortuguesaAmorim, Adriany das Graças NascimentoVasconcelos, Andreanne GomesSouza, JessicaOliveira, AnaGullón, BeatrizLeite, José Roberto de Souza de AlmeidaPintado, Manuela2022-03-03T10:48:29Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/36863eng2076-392110.3390/antiox1102036085124289342PMC886840835204241000770906900001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-16T01:43:12Zoai:repositorio.ucp.pt:10400.14/36863Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:29:58.149798Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
title |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
spellingShingle |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting Amorim, Adriany das Graças Nascimento Anti-inflammatory Bio-availability Cancer Lycopene Nanostructure |
title_short |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
title_full |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
title_fullStr |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
title_full_unstemmed |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
title_sort |
Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting |
author |
Amorim, Adriany das Graças Nascimento |
author_facet |
Amorim, Adriany das Graças Nascimento Vasconcelos, Andreanne Gomes Souza, Jessica Oliveira, Ana Gullón, Beatriz Leite, José Roberto de Souza de Almeida Pintado, Manuela |
author_role |
author |
author2 |
Vasconcelos, Andreanne Gomes Souza, Jessica Oliveira, Ana Gullón, Beatriz Leite, José Roberto de Souza de Almeida Pintado, Manuela |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Amorim, Adriany das Graças Nascimento Vasconcelos, Andreanne Gomes Souza, Jessica Oliveira, Ana Gullón, Beatriz Leite, José Roberto de Souza de Almeida Pintado, Manuela |
dc.subject.por.fl_str_mv |
Anti-inflammatory Bio-availability Cancer Lycopene Nanostructure |
topic |
Anti-inflammatory Bio-availability Cancer Lycopene Nanostructure |
description |
The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-03T10:48:29Z 2022-02 2022-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/36863 |
url |
http://hdl.handle.net/10400.14/36863 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-3921 10.3390/antiox11020360 85124289342 PMC8868408 35204241 000770906900001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132020603879424 |