The amyloidogenic potential and behavioral correlates of stress
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/64301 |
Resumo: | Observations of elevated basal cortisol levels in Alzheimer's disease (AD) patients prompted the hypothesis that stress and glucocorticoids (GC) may contribute to the development and/or maintenance of AD. Consistent with that hypothesis, we show that stress and GC provoke misprocessing of amyloid precursor peptide in the rat hippocampus and prefrontal cortex, resulting in increased levels of the peptide C-terminal fragment 99 (C99), whose further proteolytic cleavage results in the generation of amyloid-beta (Abeta). We also show that exogenous Abeta can reproduce the effects of stress and GC on C99 production and that a history of stress strikingly potentiates the C99-inducing effects of Abeta and GC. Previous work has indicated a role for Abeta in disruption of synaptic function and cognitive behaviors, and AD patients reportedly show signs of heightened anxiety. Here, behavioral analysis revealed that like stress and GC, Abeta administration causes spatial memory deficits that are exacerbated by stress and GC; additionally, Abeta, stress and GC induced a state of hyperanxiety. Given that the intrinsic properties of C99 and Abeta include neuroendangerment and behavioral impairment, our findings suggest a causal role for stress and GC in the etiopathogenesis of AD, and demonstrate that stressful life events and GC therapy can have a cumulative impact on the course of AD development and progression. |
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The amyloidogenic potential and behavioral correlates of stressAmyloid beta-Protein PrecursorAnalysis of VarianceAnimalsBehavior, AnimalDisease Models, AnimalEmotionsGlucocorticoidsHippocampusMaleMemoryPrefrontal CortexRatsRats, WistarSpace PerceptionStress, PsychologicalAlzheimer’s diseaseAmyloid precursor proteinAmyloid-bGlucocorticoidsAnxietyAmyloid-βScience & TechnologyObservations of elevated basal cortisol levels in Alzheimer's disease (AD) patients prompted the hypothesis that stress and glucocorticoids (GC) may contribute to the development and/or maintenance of AD. Consistent with that hypothesis, we show that stress and GC provoke misprocessing of amyloid precursor peptide in the rat hippocampus and prefrontal cortex, resulting in increased levels of the peptide C-terminal fragment 99 (C99), whose further proteolytic cleavage results in the generation of amyloid-beta (Abeta). We also show that exogenous Abeta can reproduce the effects of stress and GC on C99 production and that a history of stress strikingly potentiates the C99-inducing effects of Abeta and GC. Previous work has indicated a role for Abeta in disruption of synaptic function and cognitive behaviors, and AD patients reportedly show signs of heightened anxiety. Here, behavioral analysis revealed that like stress and GC, Abeta administration causes spatial memory deficits that are exacerbated by stress and GC; additionally, Abeta, stress and GC induced a state of hyperanxiety. Given that the intrinsic properties of C99 and Abeta include neuroendangerment and behavioral impairment, our findings suggest a causal role for stress and GC in the etiopathogenesis of AD, and demonstrate that stressful life events and GC therapy can have a cumulative impact on the course of AD development and progression.CC and IS were supported by stipends from the Max Planck Society and EU Marie Curie Training Fellowships (at University College London, UK). The collaboration between the German and Portuguese laboratories was supported through the German–Portuguese Luso-Alemas Program (DAAD/GRICES). This study was conducted within the framework of the EU-supported integrated project ‘CRESCENDO’ (Contract FP6-018652).Nature Publishing GroupUniversidade do MinhoCatania, C.Sotiropoulos, I.Silva, R.Onofri, C.Breen, K. C.Sousa, NunoAlmeida, O. F. X.2009-012009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/64301eng1359-41841476-557810.1038/sj.mp.400210117912249https://www.nature.com/articles/4002101info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:15Zoai:repositorium.sdum.uminho.pt:1822/64301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:28.134234Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The amyloidogenic potential and behavioral correlates of stress |
title |
The amyloidogenic potential and behavioral correlates of stress |
spellingShingle |
The amyloidogenic potential and behavioral correlates of stress Catania, C. Amyloid beta-Protein Precursor Analysis of Variance Animals Behavior, Animal Disease Models, Animal Emotions Glucocorticoids Hippocampus Male Memory Prefrontal Cortex Rats Rats, Wistar Space Perception Stress, Psychological Alzheimer’s disease Amyloid precursor protein Amyloid-b Glucocorticoids Anxiety Amyloid-β Science & Technology |
title_short |
The amyloidogenic potential and behavioral correlates of stress |
title_full |
The amyloidogenic potential and behavioral correlates of stress |
title_fullStr |
The amyloidogenic potential and behavioral correlates of stress |
title_full_unstemmed |
The amyloidogenic potential and behavioral correlates of stress |
title_sort |
The amyloidogenic potential and behavioral correlates of stress |
author |
Catania, C. |
author_facet |
Catania, C. Sotiropoulos, I. Silva, R. Onofri, C. Breen, K. C. Sousa, Nuno Almeida, O. F. X. |
author_role |
author |
author2 |
Sotiropoulos, I. Silva, R. Onofri, C. Breen, K. C. Sousa, Nuno Almeida, O. F. X. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Catania, C. Sotiropoulos, I. Silva, R. Onofri, C. Breen, K. C. Sousa, Nuno Almeida, O. F. X. |
dc.subject.por.fl_str_mv |
Amyloid beta-Protein Precursor Analysis of Variance Animals Behavior, Animal Disease Models, Animal Emotions Glucocorticoids Hippocampus Male Memory Prefrontal Cortex Rats Rats, Wistar Space Perception Stress, Psychological Alzheimer’s disease Amyloid precursor protein Amyloid-b Glucocorticoids Anxiety Amyloid-β Science & Technology |
topic |
Amyloid beta-Protein Precursor Analysis of Variance Animals Behavior, Animal Disease Models, Animal Emotions Glucocorticoids Hippocampus Male Memory Prefrontal Cortex Rats Rats, Wistar Space Perception Stress, Psychological Alzheimer’s disease Amyloid precursor protein Amyloid-b Glucocorticoids Anxiety Amyloid-β Science & Technology |
description |
Observations of elevated basal cortisol levels in Alzheimer's disease (AD) patients prompted the hypothesis that stress and glucocorticoids (GC) may contribute to the development and/or maintenance of AD. Consistent with that hypothesis, we show that stress and GC provoke misprocessing of amyloid precursor peptide in the rat hippocampus and prefrontal cortex, resulting in increased levels of the peptide C-terminal fragment 99 (C99), whose further proteolytic cleavage results in the generation of amyloid-beta (Abeta). We also show that exogenous Abeta can reproduce the effects of stress and GC on C99 production and that a history of stress strikingly potentiates the C99-inducing effects of Abeta and GC. Previous work has indicated a role for Abeta in disruption of synaptic function and cognitive behaviors, and AD patients reportedly show signs of heightened anxiety. Here, behavioral analysis revealed that like stress and GC, Abeta administration causes spatial memory deficits that are exacerbated by stress and GC; additionally, Abeta, stress and GC induced a state of hyperanxiety. Given that the intrinsic properties of C99 and Abeta include neuroendangerment and behavioral impairment, our findings suggest a causal role for stress and GC in the etiopathogenesis of AD, and demonstrate that stressful life events and GC therapy can have a cumulative impact on the course of AD development and progression. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01 2009-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/64301 |
url |
http://hdl.handle.net/1822/64301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1359-4184 1476-5578 10.1038/sj.mp.4002101 17912249 https://www.nature.com/articles/4002101 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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