Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/49661 |
Resumo: | Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments |
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Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's diseaseCiências Médicas::Medicina ClínicaScience & TechnologyDeep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatmentsIn this work, Gustavo Deco is supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research Project PSI2016-75688-P and by the the European Union's Horizon 2020 research and innovation programme under grant agreement n. 720270 (HBP SGA1). Morten Kringelbach is supported by the ERC Consolidator Grant CAREGIVING (n. 615539) and the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). Victor M Saenger is supported by the Research Personnel Training program PSI2013-42091-P funded by the Spanish Ministry of Economy and Competitiveness.info:eu-repo/semantics/publishedVersionNature Publishing Groupet. al.Universidade do MinhoSaenger, Victor M.Kahan, JoshuaFoltynie, TomFriston, KarlAziz, Tipu Z.Green, Alexander L.Hartevelt , Tim J. vanCabral, JoanaMarques, Paulo César GonçalvesSousa, Nuno20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49661engSaenger, V. M., Kahan, J., Foltynie, T., Friston, K., Aziz, T. Z., Green, A. L., ... & Mancini, L. (2017). Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease. Scientific Reports, 7(1), 98821662-515310.1038/s41598-017-10003-y28851996https://www.nature.com/articles/s41598-017-10003-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:47Zoai:repositorium.sdum.uminho.pt:1822/49661Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:57.558530Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
title |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
spellingShingle |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease Saenger, Victor M. Ciências Médicas::Medicina Clínica Science & Technology |
title_short |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
title_full |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
title_fullStr |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
title_full_unstemmed |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
title_sort |
Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease |
author |
Saenger, Victor M. |
author_facet |
Saenger, Victor M. Kahan, Joshua Foltynie, Tom Friston, Karl Aziz, Tipu Z. Green, Alexander L. Hartevelt , Tim J. van Cabral, Joana Marques, Paulo César Gonçalves Sousa, Nuno |
author_role |
author |
author2 |
Kahan, Joshua Foltynie, Tom Friston, Karl Aziz, Tipu Z. Green, Alexander L. Hartevelt , Tim J. van Cabral, Joana Marques, Paulo César Gonçalves Sousa, Nuno |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
et. al. Universidade do Minho |
dc.contributor.author.fl_str_mv |
Saenger, Victor M. Kahan, Joshua Foltynie, Tom Friston, Karl Aziz, Tipu Z. Green, Alexander L. Hartevelt , Tim J. van Cabral, Joana Marques, Paulo César Gonçalves Sousa, Nuno |
dc.subject.por.fl_str_mv |
Ciências Médicas::Medicina Clínica Science & Technology |
topic |
Ciências Médicas::Medicina Clínica Science & Technology |
description |
Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/49661 |
url |
http://hdl.handle.net/1822/49661 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Saenger, V. M., Kahan, J., Foltynie, T., Friston, K., Aziz, T. Z., Green, A. L., ... & Mancini, L. (2017). Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease. Scientific Reports, 7(1), 9882 1662-5153 10.1038/s41598-017-10003-y 28851996 https://www.nature.com/articles/s41598-017-10003-y |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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