Cyanotoxins: from poisoning to healing – A possible pathway?

• Autor(a) principal: Dias, Elsa
• Data de Publicação: 2015
• Outros Autores: Paulino, Sérgio, Pereira, Paulo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/3559
• topic: Cyanotoxins; Health; New Drugs; Cyanobacterias; Água e Solo

[ENG] Cyanobacteria are photosynthetic microorganisms known for their multiple, and occasionally dual, ecologic roles. Cyanobacteria are major contributors to oxygen production on earth, but they often bloom in freshwater environments, depleting oxygen and inducing massive fish kills by anoxia. In addition, cyanobacteria are primary producers and the base of the food web in aquatic ecosystems, but they often “crowd out” other phytoplanktonic organisms by competing for nutrients. Cyanobacteria produce an array of beneficial, biologically active compounds, but some of their secondary metabolites are also known to be highly toxic to humans. Many cyanobacterial characteristics are still a mystery and raise many unsolved questions: Why do they bloom? How do they “communicate” with each other and “synchronise” to flourish? How do they colonise so many diverse habitats and are resistant to the most adverse of environments? Why do some strains produce toxins while others do not? Current research on cyanobacteria may provide answers to these “old” questions, but may also challenge us to consider new perspectives. In this paper, we will discuss the potential therapeutic application of cyanobacterial toxins, most of which are known as potent toxicants, but some of which have a non-negligible potential for drug discovery.