Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004 |
Resumo: | BACKGROUND AND AIMS: Current Guidelines recommend that cirrhotic patients should undergo upper gastrointestinal endoscopy for screening of esophageal varices. Several studies evaluated the ability of non-invasive markers to predict the presence of esophageal varices. We aimed to test the validity of platelet count-to-spleen diameter ratio (PC/SD) to predict the presence of esophageal varices as well as endoscopic signs of severe portal hypertension (large varices, red signs on esophageal varices and severe portal hypertensive gastropathy) using the 909 cut-off value. PATIENTS AND METHODS : Retrospective study of 170 cirrhotic patients, who underwent screening for esophageal varices. Liver cirrhosis etiology, laboratory, ultrasonography and endoscopy data were analyzed. STATS: Mann-Whitney test, X2, ROC curves. RESULTS: 170 patients (55 female) were included. One hundred and three (60,6%) had esophageal varices (34,1% large; 11,8% with red signs). Ninety-seven patients (57,1%) had portal hypertensive gastropathy (PHG): with severe PHG in 38 (22,3%). PC/SD <909 was documented in 93 patients. It was significantly associated with the presence of esophageal varices (P<0,001; AUROC= 0,84) and high-risk esophageal varices (large varices or red signs - P<0,001; AUROC= 0,8). The score was also significantly associated with the presence of severe portal hypertensive gastropathy (P<0,001; AUROC= 0,63). CONCLUSIONS: PC/SD is significantly associated with the presence of esophageal varices and portal hypertensive gastropathy. A PC/SD ≥909 is a good predictor of the absence of high-risk varices or severe portal hypertensive gastropathy |
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Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patientsEsophageal varicesportal hypertensionplatelet count to spleen diameter ratioliver cirrhosisBACKGROUND AND AIMS: Current Guidelines recommend that cirrhotic patients should undergo upper gastrointestinal endoscopy for screening of esophageal varices. Several studies evaluated the ability of non-invasive markers to predict the presence of esophageal varices. We aimed to test the validity of platelet count-to-spleen diameter ratio (PC/SD) to predict the presence of esophageal varices as well as endoscopic signs of severe portal hypertension (large varices, red signs on esophageal varices and severe portal hypertensive gastropathy) using the 909 cut-off value. PATIENTS AND METHODS : Retrospective study of 170 cirrhotic patients, who underwent screening for esophageal varices. Liver cirrhosis etiology, laboratory, ultrasonography and endoscopy data were analyzed. STATS: Mann-Whitney test, X2, ROC curves. RESULTS: 170 patients (55 female) were included. One hundred and three (60,6%) had esophageal varices (34,1% large; 11,8% with red signs). Ninety-seven patients (57,1%) had portal hypertensive gastropathy (PHG): with severe PHG in 38 (22,3%). PC/SD <909 was documented in 93 patients. It was significantly associated with the presence of esophageal varices (P<0,001; AUROC= 0,84) and high-risk esophageal varices (large varices or red signs - P<0,001; AUROC= 0,8). The score was also significantly associated with the presence of severe portal hypertensive gastropathy (P<0,001; AUROC= 0,63). CONCLUSIONS: PC/SD is significantly associated with the presence of esophageal varices and portal hypertensive gastropathy. A PC/SD ≥909 is a good predictor of the absence of high-risk varices or severe portal hypertensive gastropathySociedade Portuguesa de Gastrenterologia2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004Jornal Português de Gastrenterologia v.19 n.1 2012reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004Afonso,MiguelPinto,JoanaVeloso,RicardoFreitas,TeresaCarvalho,JoãoFraga,Joséinfo:eu-repo/semantics/openAccess2024-02-06T17:09:07Zoai:scielo:S0872-81782012000100004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:21:15.056031Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
title |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
spellingShingle |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients Afonso,Miguel Esophageal varices portal hypertension platelet count to spleen diameter ratio liver cirrhosis |
title_short |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
title_full |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
title_fullStr |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
title_full_unstemmed |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
title_sort |
Manifestations of severe portal hypertension: Validation of a non-invasive score in cirrhotic patients |
author |
Afonso,Miguel |
author_facet |
Afonso,Miguel Pinto,Joana Veloso,Ricardo Freitas,Teresa Carvalho,João Fraga,José |
author_role |
author |
author2 |
Pinto,Joana Veloso,Ricardo Freitas,Teresa Carvalho,João Fraga,José |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Afonso,Miguel Pinto,Joana Veloso,Ricardo Freitas,Teresa Carvalho,João Fraga,José |
dc.subject.por.fl_str_mv |
Esophageal varices portal hypertension platelet count to spleen diameter ratio liver cirrhosis |
topic |
Esophageal varices portal hypertension platelet count to spleen diameter ratio liver cirrhosis |
description |
BACKGROUND AND AIMS: Current Guidelines recommend that cirrhotic patients should undergo upper gastrointestinal endoscopy for screening of esophageal varices. Several studies evaluated the ability of non-invasive markers to predict the presence of esophageal varices. We aimed to test the validity of platelet count-to-spleen diameter ratio (PC/SD) to predict the presence of esophageal varices as well as endoscopic signs of severe portal hypertension (large varices, red signs on esophageal varices and severe portal hypertensive gastropathy) using the 909 cut-off value. PATIENTS AND METHODS : Retrospective study of 170 cirrhotic patients, who underwent screening for esophageal varices. Liver cirrhosis etiology, laboratory, ultrasonography and endoscopy data were analyzed. STATS: Mann-Whitney test, X2, ROC curves. RESULTS: 170 patients (55 female) were included. One hundred and three (60,6%) had esophageal varices (34,1% large; 11,8% with red signs). Ninety-seven patients (57,1%) had portal hypertensive gastropathy (PHG): with severe PHG in 38 (22,3%). PC/SD <909 was documented in 93 patients. It was significantly associated with the presence of esophageal varices (P<0,001; AUROC= 0,84) and high-risk esophageal varices (large varices or red signs - P<0,001; AUROC= 0,8). The score was also significantly associated with the presence of severe portal hypertensive gastropathy (P<0,001; AUROC= 0,63). CONCLUSIONS: PC/SD is significantly associated with the presence of esophageal varices and portal hypertensive gastropathy. A PC/SD ≥909 is a good predictor of the absence of high-risk varices or severe portal hypertensive gastropathy |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
dc.source.none.fl_str_mv |
Jornal Português de Gastrenterologia v.19 n.1 2012 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137298769510400 |