ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?

Detalhes bibliográficos
Autor(a) principal: Coelho, Andreia
Data de Publicação: 2017
Outros Autores: Lobo, Miguel, Gouveia, Ricardo, Campos, Jacinta, Augusto, Rita, Coelho, Nuno, Canedo, Alexandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48750/acv.116
Resumo: Introduction: The rupture of an abdominal aortic aneurysm (AAA) is frequently fatal and accounts for nearly 1% of all deaths. Data from literature states that screening is cost effective in male patients over the age of 65 with a 44% reduction in AAA related mortality. UK small aneurysm trial participants and other trials concluded that there was no long-term survival benefit of early elective open repair of small AAA (40-55mm). However when these trials began, endovascular aneurysm repair (EVAR) was not an option. Since many consider that EVAR is easier in smaller aneurysms, trials of early endovascular repair versus surveillance for small AAA are ongoing. The purpose of this study was to identify the proportion of abdominal aortic aneurysm ruptures that occur before the screening age or threshold diameter for operative repair is reached. Methods: The clinical data of all patients admitted in our hospital with the diagnosis of ruptured AAA from January 2007 to December 2015 were retrospectively reviewed. Results: A total of 60 patients were included in this study, 52 males and 8 females. Mean age at rupture was 74.6±9.5years. Eleven patients (18.3%) were younger than 65 years, with 21.1% of males and no females under the age of 65. Mean aneurysm diameter at rupture was 72.8±20mm. 12 patients (20%) had aneurysm size inferior to 55mm at rupture, and only in one of those infectious etiology was confirmed by histologic analysis. Female rupture below 55 mm reached 37.5% and male rupture reached 15.4%, with no statistically significant difference probably because of the small number of female patients. Between male patients, rupture occurred at a significantly inferior diameter in smokers (p<0,05). Conclusions: The data from this study show that a 21% of men would not make it to the screening age of 65 before AAA rupture. It also shows that 20% of patients treated for ruptured AAA were below 55 mm diameter. Data from this study also support the previous finding that aneurysm size at the time of rupture is significantly smaller in male smokers.
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spelling ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?ROTURA DE ANEURISMA DA AORTA ABDOMINAL: QUAL A VERDADEIRA PREVALÊNCIA DE DOENTES SEM CRITÉRIOS PARA RASTREIO OU TRATAMENTO ELETIVO?Aneurisma da aorta abdominalRastreioPrevenção primáriaRotura de aneurisma da aorta abdominalFatores de riscoAbdominal aortic aneurysmScreeningPrimary preventionRuptured abdominal aortic aneurysmRisk factorsIntroduction: The rupture of an abdominal aortic aneurysm (AAA) is frequently fatal and accounts for nearly 1% of all deaths. Data from literature states that screening is cost effective in male patients over the age of 65 with a 44% reduction in AAA related mortality. UK small aneurysm trial participants and other trials concluded that there was no long-term survival benefit of early elective open repair of small AAA (40-55mm). However when these trials began, endovascular aneurysm repair (EVAR) was not an option. Since many consider that EVAR is easier in smaller aneurysms, trials of early endovascular repair versus surveillance for small AAA are ongoing. The purpose of this study was to identify the proportion of abdominal aortic aneurysm ruptures that occur before the screening age or threshold diameter for operative repair is reached. Methods: The clinical data of all patients admitted in our hospital with the diagnosis of ruptured AAA from January 2007 to December 2015 were retrospectively reviewed. Results: A total of 60 patients were included in this study, 52 males and 8 females. Mean age at rupture was 74.6±9.5years. Eleven patients (18.3%) were younger than 65 years, with 21.1% of males and no females under the age of 65. Mean aneurysm diameter at rupture was 72.8±20mm. 12 patients (20%) had aneurysm size inferior to 55mm at rupture, and only in one of those infectious etiology was confirmed by histologic analysis. Female rupture below 55 mm reached 37.5% and male rupture reached 15.4%, with no statistically significant difference probably because of the small number of female patients. Between male patients, rupture occurred at a significantly inferior diameter in smokers (p<0,05). Conclusions: The data from this study show that a 21% of men would not make it to the screening age of 65 before AAA rupture. It also shows that 20% of patients treated for ruptured AAA were below 55 mm diameter. Data from this study also support the previous finding that aneurysm size at the time of rupture is significantly smaller in male smokers.Introdução: A rotura de um aneurisma da aorta abdominal (AAA) é um evento frequentemente fatal, responsável por cerca de 1% da mortalidade global. Estudos publicados constatam que o rastreio é custo-efetivo em doentes do sexo masculino com idade superior a 65 anos, com uma redução de 44% da mortalidade específica por AAA. Estudos na literatura, incluindo o UK Small Aneurysm Trial participants, concluíram não existir beneficio a longo prazo do tratamento eletivo precoce de AAA (40-55mm). No entanto, estes estudos foram realizados previamente à vulgarização do tratamento endovascular de aneurisma (EVAR). Uma vez que a realização de EVAR é mais simples em doentes com AAA de menores dimensões, estudos comparativos entre tratamento expectante e EVAR estão em curso. O objetivo deste estudo foi identificar a percentagem de casos de roturas que ocorrem antes da idade de rastreio bem como antes do limiar de tamanho para tratamento eletivo. Pretendeu-se também identificar preditores de rotura fora do limiar para rastreio ou tratamento eletivo. Métodos: Foram selecionados os doentes admitidos no nosso centro com o diagnóstico de rotura de AAA entre janeiro de 2007 e dezembro de 2015 e procedeu-se à análise estatística dos dados. Resultados: Foram selecionados um total de 60 doentes, 52 do sexo masculino e 8 do sexo feminino. A idade média à data da rotura foi de 74,6±9,5 anos. Onze doentes (18,3%) dos doentes tinham idade inferior a 65 anos, 21% dos doentes do sexo masculino. O diâmetro transversal médio à data da rotura foi de 72,8±20 mm. 12 doentes (20%) apresentavam dimensões inferiores a 55 mm à data da rotura, sendo que apenas em um caso se confirmou uma etiologia infeciosa. Em mulheres a prevalência de roturas antes dos 55 mm atingiu 37.5%, por oposição a 15.4% no sexo masculino, sem diferença estatisticamente significativa. A rotura ocorreu em diâmetros significativamente inferiores em fumadores (p<0,05). Discussão: Dados deste estudo demonstram que 21% dos doentes do sexo masculino sofrem rotura de AAA antes de atingirem o limiar de idade para rastreio. Também se constatou que 20% dos doentes tratados em contexto de rotura não tinham atingido o limiar de diâmetro para reparação eletiva. A rotura ocorreu em aneurismas significativamente mais pequenos em doentes fumadores (p<0,05).Sociedade Portuguesa de Angiologia e Cirurgia Vascular2017-11-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.116oai:ojs.acvjournal.com:article/116Angiologia e Cirurgia Vascular; Vol. 13 No. 2 (2017): June; 35-41Angiologia e Cirurgia Vascular; Vol. 13 N.º 2 (2017): Junho; 35-412183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://acvjournal.com/index.php/acv/article/view/116https://doi.org/10.48750/acv.116http://acvjournal.com/index.php/acv/article/view/116/24Copyright (c) 2017 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessCoelho, AndreiaLobo, MiguelGouveia, RicardoCampos, JacintaAugusto, RitaCoelho, NunoCanedo, Alexandra2022-05-23T15:10:02Zoai:ojs.acvjournal.com:article/116Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:57:30.950361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
ROTURA DE ANEURISMA DA AORTA ABDOMINAL: QUAL A VERDADEIRA PREVALÊNCIA DE DOENTES SEM CRITÉRIOS PARA RASTREIO OU TRATAMENTO ELETIVO?
title ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
spellingShingle ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
Coelho, Andreia
Aneurisma da aorta abdominal
Rastreio
Prevenção primária
Rotura de aneurisma da aorta abdominal
Fatores de risco
Abdominal aortic aneurysm
Screening
Primary prevention
Ruptured abdominal aortic aneurysm
Risk factors
title_short ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
title_full ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
title_fullStr ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
title_full_unstemmed ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
title_sort ABDOMINAL AORTIC ANEURYSM RUPTURE: WHAT IS THE REAL PREVALENCE IN PATIENTS WITH NO CRITERIA FOR SCREENING OR ELECTIVE REPAIR?
author Coelho, Andreia
author_facet Coelho, Andreia
Lobo, Miguel
Gouveia, Ricardo
Campos, Jacinta
Augusto, Rita
Coelho, Nuno
Canedo, Alexandra
author_role author
author2 Lobo, Miguel
Gouveia, Ricardo
Campos, Jacinta
Augusto, Rita
Coelho, Nuno
Canedo, Alexandra
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coelho, Andreia
Lobo, Miguel
Gouveia, Ricardo
Campos, Jacinta
Augusto, Rita
Coelho, Nuno
Canedo, Alexandra
dc.subject.por.fl_str_mv Aneurisma da aorta abdominal
Rastreio
Prevenção primária
Rotura de aneurisma da aorta abdominal
Fatores de risco
Abdominal aortic aneurysm
Screening
Primary prevention
Ruptured abdominal aortic aneurysm
Risk factors
topic Aneurisma da aorta abdominal
Rastreio
Prevenção primária
Rotura de aneurisma da aorta abdominal
Fatores de risco
Abdominal aortic aneurysm
Screening
Primary prevention
Ruptured abdominal aortic aneurysm
Risk factors
description Introduction: The rupture of an abdominal aortic aneurysm (AAA) is frequently fatal and accounts for nearly 1% of all deaths. Data from literature states that screening is cost effective in male patients over the age of 65 with a 44% reduction in AAA related mortality. UK small aneurysm trial participants and other trials concluded that there was no long-term survival benefit of early elective open repair of small AAA (40-55mm). However when these trials began, endovascular aneurysm repair (EVAR) was not an option. Since many consider that EVAR is easier in smaller aneurysms, trials of early endovascular repair versus surveillance for small AAA are ongoing. The purpose of this study was to identify the proportion of abdominal aortic aneurysm ruptures that occur before the screening age or threshold diameter for operative repair is reached. Methods: The clinical data of all patients admitted in our hospital with the diagnosis of ruptured AAA from January 2007 to December 2015 were retrospectively reviewed. Results: A total of 60 patients were included in this study, 52 males and 8 females. Mean age at rupture was 74.6±9.5years. Eleven patients (18.3%) were younger than 65 years, with 21.1% of males and no females under the age of 65. Mean aneurysm diameter at rupture was 72.8±20mm. 12 patients (20%) had aneurysm size inferior to 55mm at rupture, and only in one of those infectious etiology was confirmed by histologic analysis. Female rupture below 55 mm reached 37.5% and male rupture reached 15.4%, with no statistically significant difference probably because of the small number of female patients. Between male patients, rupture occurred at a significantly inferior diameter in smokers (p<0,05). Conclusions: The data from this study show that a 21% of men would not make it to the screening age of 65 before AAA rupture. It also shows that 20% of patients treated for ruptured AAA were below 55 mm diameter. Data from this study also support the previous finding that aneurysm size at the time of rupture is significantly smaller in male smokers.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48750/acv.116
oai:ojs.acvjournal.com:article/116
url https://doi.org/10.48750/acv.116
identifier_str_mv oai:ojs.acvjournal.com:article/116
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://acvjournal.com/index.php/acv/article/view/116
https://doi.org/10.48750/acv.116
http://acvjournal.com/index.php/acv/article/view/116/24
dc.rights.driver.fl_str_mv Copyright (c) 2017 Angiologia e Cirurgia Vascular
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Angiologia e Cirurgia Vascular
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular; Vol. 13 No. 2 (2017): June; 35-41
Angiologia e Cirurgia Vascular; Vol. 13 N.º 2 (2017): Junho; 35-41
2183-0096
1646-706X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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