Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/41536 |
Resumo: | Neural stem cells (NSCs) and mesenchymal stem cells (MSCs) share few characteristics apart from self-renewal and multipotency. In fact, the neurogenic and osteogenic stem cell niches derive from two distinct embryonary structures; while the later originates from the mesoderm, as all the connective tissues do, the first derives from the ectoderm. Therefore, it is highly unlikely that stem cells isolated from one niche could form terminally differentiated cells from the other. Additionally, these two niches are associated to tissues/systems (e.g., bone and central nervous system) that have markedly different needs and display diverse functions within the human body. Nevertheless they do share common features. For instance, the differentiation of both NSCs and MSCs is intimately associated with the bone morphogenetic protein family. Moreover, both NSCs and MSCs secrete a panel of common growth factors, such as nerve growth factor (NGF), glial derived neurotrophic factor (GDNF), and brain derived neurotrophic factor (BDNF), among others. But it is not the features they share but the interaction between them that seem most important, and worth exploring; namely, it has already been shown that there are mutually beneficially effects when these cell types are co-cultured in vitro. In fact the use of MSCs, and their secretome, become a strong candidate to be used as a therapeutic tool for CNS applications, namely by triggering the endogenous proliferation and differentiation of neural progenitors, among other mechanisms. Quite interestingly it was recently revealed that MSCs could be found in the human brain, in the vicinity of capillaries. In the present review we highlight how MSCs and NSCs in the neurogenic niches interact. Furthermore, we propose directions on this field and explore the future therapeutic possibilities that may arise from the combination/interaction of MSCs and NSCs. |
id |
RCAP_79b1dff383ebad4229ec84a22b719f2d |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/41536 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunitiesmesenchymal stem cells,neural stem cellsnicheneurogenesissecretomeregenerative medicineinteractionsCiências Médicas::Ciências da SaúdeScience & TechnologyNeural stem cells (NSCs) and mesenchymal stem cells (MSCs) share few characteristics apart from self-renewal and multipotency. In fact, the neurogenic and osteogenic stem cell niches derive from two distinct embryonary structures; while the later originates from the mesoderm, as all the connective tissues do, the first derives from the ectoderm. Therefore, it is highly unlikely that stem cells isolated from one niche could form terminally differentiated cells from the other. Additionally, these two niches are associated to tissues/systems (e.g., bone and central nervous system) that have markedly different needs and display diverse functions within the human body. Nevertheless they do share common features. For instance, the differentiation of both NSCs and MSCs is intimately associated with the bone morphogenetic protein family. Moreover, both NSCs and MSCs secrete a panel of common growth factors, such as nerve growth factor (NGF), glial derived neurotrophic factor (GDNF), and brain derived neurotrophic factor (BDNF), among others. But it is not the features they share but the interaction between them that seem most important, and worth exploring; namely, it has already been shown that there are mutually beneficially effects when these cell types are co-cultured in vitro. In fact the use of MSCs, and their secretome, become a strong candidate to be used as a therapeutic tool for CNS applications, namely by triggering the endogenous proliferation and differentiation of neural progenitors, among other mechanisms. Quite interestingly it was recently revealed that MSCs could be found in the human brain, in the vicinity of capillaries. In the present review we highlight how MSCs and NSCs in the neurogenic niches interact. Furthermore, we propose directions on this field and explore the future therapeutic possibilities that may arise from the combination/interaction of MSCs and NSCs.Portuguese Foundation for Science and Technology (FCT; IF Development Grant to AJS; IF Starting Grant to BMC); Bial Foundation (Grant 217/12 to JCS); co-funded by Programa Operacional Regional do Norte (ON.2 – O Novo Norte), ao abrigo do Quadro de Referência Estratégico Nacional (QREN),atravésdoFundoEuropeudeDesenvolvimentoRegional (FEDER).Frontiers MediaUniversidade do MinhoSalgado, A. J.Sousa, João CarlosCosta, B. M.Pires, A. O.Mateus-Pinheiro, A.Teixeira, F. G.Pinto, LuísaSousa, Nuno20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/41536engSalgado, A. J., Sousa, J. C., Costa, B. M., Pires, A. O., Mateus-Pinheiro, A., Teixeira, F. G., . . . Sousa, N. (2015). Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities. Frontiers in Cellular Neuroscience, 9. doi: 10.3389/fncel.2015.002491662-510210.3389/fncel.2015.00249http://journal.frontiersin.orginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:15Zoai:repositorium.sdum.uminho.pt:1822/41536Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:08.420834Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
title |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
spellingShingle |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities Salgado, A. J. mesenchymal stem cells, neural stem cells niche neurogenesis secretome regenerative medicine interactions Ciências Médicas::Ciências da Saúde Science & Technology |
title_short |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
title_full |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
title_fullStr |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
title_full_unstemmed |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
title_sort |
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities |
author |
Salgado, A. J. |
author_facet |
Salgado, A. J. Sousa, João Carlos Costa, B. M. Pires, A. O. Mateus-Pinheiro, A. Teixeira, F. G. Pinto, Luísa Sousa, Nuno |
author_role |
author |
author2 |
Sousa, João Carlos Costa, B. M. Pires, A. O. Mateus-Pinheiro, A. Teixeira, F. G. Pinto, Luísa Sousa, Nuno |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Salgado, A. J. Sousa, João Carlos Costa, B. M. Pires, A. O. Mateus-Pinheiro, A. Teixeira, F. G. Pinto, Luísa Sousa, Nuno |
dc.subject.por.fl_str_mv |
mesenchymal stem cells, neural stem cells niche neurogenesis secretome regenerative medicine interactions Ciências Médicas::Ciências da Saúde Science & Technology |
topic |
mesenchymal stem cells, neural stem cells niche neurogenesis secretome regenerative medicine interactions Ciências Médicas::Ciências da Saúde Science & Technology |
description |
Neural stem cells (NSCs) and mesenchymal stem cells (MSCs) share few characteristics apart from self-renewal and multipotency. In fact, the neurogenic and osteogenic stem cell niches derive from two distinct embryonary structures; while the later originates from the mesoderm, as all the connective tissues do, the first derives from the ectoderm. Therefore, it is highly unlikely that stem cells isolated from one niche could form terminally differentiated cells from the other. Additionally, these two niches are associated to tissues/systems (e.g., bone and central nervous system) that have markedly different needs and display diverse functions within the human body. Nevertheless they do share common features. For instance, the differentiation of both NSCs and MSCs is intimately associated with the bone morphogenetic protein family. Moreover, both NSCs and MSCs secrete a panel of common growth factors, such as nerve growth factor (NGF), glial derived neurotrophic factor (GDNF), and brain derived neurotrophic factor (BDNF), among others. But it is not the features they share but the interaction between them that seem most important, and worth exploring; namely, it has already been shown that there are mutually beneficially effects when these cell types are co-cultured in vitro. In fact the use of MSCs, and their secretome, become a strong candidate to be used as a therapeutic tool for CNS applications, namely by triggering the endogenous proliferation and differentiation of neural progenitors, among other mechanisms. Quite interestingly it was recently revealed that MSCs could be found in the human brain, in the vicinity of capillaries. In the present review we highlight how MSCs and NSCs in the neurogenic niches interact. Furthermore, we propose directions on this field and explore the future therapeutic possibilities that may arise from the combination/interaction of MSCs and NSCs. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/41536 |
url |
http://hdl.handle.net/1822/41536 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Salgado, A. J., Sousa, J. C., Costa, B. M., Pires, A. O., Mateus-Pinheiro, A., Teixeira, F. G., . . . Sousa, N. (2015). Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities. Frontiers in Cellular Neuroscience, 9. doi: 10.3389/fncel.2015.00249 1662-5102 10.3389/fncel.2015.00249 http://journal.frontiersin.org |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132371238256640 |