Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1186/s12872-019-1181-5 |
Resumo: | BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness. |
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Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessmentElectrocardiographyHeart rate variabilityRemote ischemic conditioningCardiology and Cardiovascular MedicineBACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.LIBPhys-UNLDF – Departamento de FísicaNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNOsório, Daniel NoronhaViana-Soares, RicardoMarto, João PedroMendonça, Marcelo D.Silva, Hugo P.Quaresma, CláudiaViana-Baptista, MiguelGamboa, HugoVieira, Helena L. A.2019-09-18T22:50:44Z2019-09-092019-09-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttps://doi.org/10.1186/s12872-019-1181-5eng1471-2261PURE: 14687283http://www.scopus.com/inward/record.url?scp=85071976280&partnerID=8YFLogxKhttps://doi.org/10.1186/s12872-019-1181-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:36:24Zoai:run.unl.pt:10362/81694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:36:07.870204Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
spellingShingle |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment Osório, Daniel Noronha Electrocardiography Heart rate variability Remote ischemic conditioning Cardiology and Cardiovascular Medicine |
title_short |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_full |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_fullStr |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_full_unstemmed |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_sort |
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
author |
Osório, Daniel Noronha |
author_facet |
Osório, Daniel Noronha Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. |
author_role |
author |
author2 |
Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
LIBPhys-UNL DF – Departamento de Física NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Osório, Daniel Noronha Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. |
dc.subject.por.fl_str_mv |
Electrocardiography Heart rate variability Remote ischemic conditioning Cardiology and Cardiovascular Medicine |
topic |
Electrocardiography Heart rate variability Remote ischemic conditioning Cardiology and Cardiovascular Medicine |
description |
BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-18T22:50:44Z 2019-09-09 2019-09-09T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1186/s12872-019-1181-5 |
url |
https://doi.org/10.1186/s12872-019-1181-5 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2261 PURE: 14687283 http://www.scopus.com/inward/record.url?scp=85071976280&partnerID=8YFLogxK https://doi.org/10.1186/s12872-019-1181-5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1 application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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