Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment

Detalhes bibliográficos
Autor(a) principal: Osório, Daniel Noronha
Data de Publicação: 2019
Outros Autores: Viana-Soares, Ricardo, Marto, João Pedro, Mendonça, Marcelo D., Silva, Hugo P., Quaresma, Cláudia, Viana-Baptista, Miguel, Gamboa, Hugo, Vieira, Helena L. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1186/s12872-019-1181-5
Resumo: BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.
id RCAP_79e8bfbc7a3e500aab4af21aa5144260
oai_identifier_str oai:run.unl.pt:10362/81694
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessmentElectrocardiographyHeart rate variabilityRemote ischemic conditioningCardiology and Cardiovascular MedicineBACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.LIBPhys-UNLDF – Departamento de FísicaNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNOsório, Daniel NoronhaViana-Soares, RicardoMarto, João PedroMendonça, Marcelo D.Silva, Hugo P.Quaresma, CláudiaViana-Baptista, MiguelGamboa, HugoVieira, Helena L. A.2019-09-18T22:50:44Z2019-09-092019-09-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttps://doi.org/10.1186/s12872-019-1181-5eng1471-2261PURE: 14687283http://www.scopus.com/inward/record.url?scp=85071976280&partnerID=8YFLogxKhttps://doi.org/10.1186/s12872-019-1181-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:36:24Zoai:run.unl.pt:10362/81694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:36:07.870204Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
spellingShingle Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
Osório, Daniel Noronha
Electrocardiography
Heart rate variability
Remote ischemic conditioning
Cardiology and Cardiovascular Medicine
title_short Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_full Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_fullStr Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_full_unstemmed Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_sort Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
author Osório, Daniel Noronha
author_facet Osório, Daniel Noronha
Viana-Soares, Ricardo
Marto, João Pedro
Mendonça, Marcelo D.
Silva, Hugo P.
Quaresma, Cláudia
Viana-Baptista, Miguel
Gamboa, Hugo
Vieira, Helena L. A.
author_role author
author2 Viana-Soares, Ricardo
Marto, João Pedro
Mendonça, Marcelo D.
Silva, Hugo P.
Quaresma, Cláudia
Viana-Baptista, Miguel
Gamboa, Hugo
Vieira, Helena L. A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LIBPhys-UNL
DF – Departamento de Física
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Osório, Daniel Noronha
Viana-Soares, Ricardo
Marto, João Pedro
Mendonça, Marcelo D.
Silva, Hugo P.
Quaresma, Cláudia
Viana-Baptista, Miguel
Gamboa, Hugo
Vieira, Helena L. A.
dc.subject.por.fl_str_mv Electrocardiography
Heart rate variability
Remote ischemic conditioning
Cardiology and Cardiovascular Medicine
topic Electrocardiography
Heart rate variability
Remote ischemic conditioning
Cardiology and Cardiovascular Medicine
description BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-18T22:50:44Z
2019-09-09
2019-09-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1186/s12872-019-1181-5
url https://doi.org/10.1186/s12872-019-1181-5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2261
PURE: 14687283
http://www.scopus.com/inward/record.url?scp=85071976280&partnerID=8YFLogxK
https://doi.org/10.1186/s12872-019-1181-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137980636463104