Design, synthesis and biological evaluation of new derivatives of phenolic metabolites

Detalhes bibliográficos
Autor(a) principal: Carregosa, Diogo
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114990
Resumo: "Multiple (poly)phenolic compounds, related with the consumption of dietary products have been described to modulate microglial cells, influencing the inflammatory response in the brain and microgliamediated neuronal apoptosis. However, low amounts of information is available about small compounds, present in human blood circulation after the metabolization of (poly)phenols. Previously we have shown some of these small metabolites, capable of crossing the blood brain barrier at physiological concentrations, and be neuroprotective.(...)"
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spelling Design, synthesis and biological evaluation of new derivatives of phenolic metabolitesNeuroinflamationNeuroprotectionBiochemistry"Multiple (poly)phenolic compounds, related with the consumption of dietary products have been described to modulate microglial cells, influencing the inflammatory response in the brain and microgliamediated neuronal apoptosis. However, low amounts of information is available about small compounds, present in human blood circulation after the metabolization of (poly)phenols. Previously we have shown some of these small metabolites, capable of crossing the blood brain barrier at physiological concentrations, and be neuroprotective.(...)"Ventura, RitaSantos, CláudiaRUNCarregosa, Diogo2021-04-04T22:49:58Z2028-02-28T00:00:00Z2018-10-192018-092018-10-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/114990engembargoacessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T15:59:16ZPortal AgregadorONG
dc.title.none.fl_str_mv Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
title Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
spellingShingle Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
Carregosa, Diogo
Neuroinflamation
Neuroprotection
Biochemistry
title_short Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
title_full Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
title_fullStr Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
title_full_unstemmed Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
title_sort Design, synthesis and biological evaluation of new derivatives of phenolic metabolites
author Carregosa, Diogo
author_facet Carregosa, Diogo
author_role author
dc.contributor.none.fl_str_mv Ventura, Rita
Santos, Cláudia
RUN
dc.contributor.author.fl_str_mv Carregosa, Diogo
dc.subject.por.fl_str_mv Neuroinflamation
Neuroprotection
Biochemistry
topic Neuroinflamation
Neuroprotection
Biochemistry
description "Multiple (poly)phenolic compounds, related with the consumption of dietary products have been described to modulate microglial cells, influencing the inflammatory response in the brain and microgliamediated neuronal apoptosis. However, low amounts of information is available about small compounds, present in human blood circulation after the metabolization of (poly)phenols. Previously we have shown some of these small metabolites, capable of crossing the blood brain barrier at physiological concentrations, and be neuroprotective.(...)"
publishDate 2018
dc.date.none.fl_str_mv 2018-10-19
2018-09
2018-10-19T00:00:00Z
2021-04-04T22:49:58Z
2028-02-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114990
url http://hdl.handle.net/10362/114990
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv embargoacess
info:eu-repo/semantics/openAccess
rights_invalid_str_mv embargoacess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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