Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association

• Autor(a) principal: Sousa,Arthur Wagner Pimentel de
• Data de Publicação: 2015
• Outros Autores: Silva,Vanessa Maia da, Fernandes,Priscilla Alencar, Araújo,Daniel Uchôa, Carvalho,Gilmar Mamede de, Villar,Erick José de Morais, Miranda-Henriques,Mônica Souza de
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452015000100004
• topic: Gastritis; Atrophic; Anemia; Pernicious; Thyroiditis; Autoimmune; Vitamin B 12 Deficiency; Spinal Cord Diseases

Introduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases. Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis. Method: Report the clinical case of a young patient that developed progressive and disabling peripheral neuropathy framework, triggered by vitamin B12 deficiency. Discussion: It was proven that atrophic gastritis with positive intrinsic anti-factor was responsible for the framework of pernicious anemia, which in turn dangerously reduced the sérum levels of vitamin B12, leading to myelopathy. There was a progressive neurological improvement after parenteral cyanocobalamin replacement, keeping the patient at ambulatory, under maintenance therapy. Conclusion: The importance of suspecting on polyglandular syndrome in the presence of autoimmune frameworks is important, especially those involving diabetes, thyroiditis, atrophic gastritis, pernicious anemia, vitiligo, among others.