Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/105560 |
Resumo: | Funding: iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. This work was supported by Fundação para a Ciência e Tecnologia (IF/01097/2013 to C.N.S.), by The Scottish Government Rural and Environment Science and Analytical Services Division (A.F. and D.S.), and BacHBerry FP7-KBBE-2013-613793 (R.M., A.F., C.J., I.C., G.G., R.R.-R., J.P., A.M., C.D., D.S. and C.N.S.). T.F.O. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), and is currently supported by the DFG under Germany’s Excellence Strategy—EXC 2067/1-390729940. |
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Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related DiseasesSDG 3 - Good Health and Well-beingFunding: iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. This work was supported by Fundação para a Ciência e Tecnologia (IF/01097/2013 to C.N.S.), by The Scottish Government Rural and Environment Science and Analytical Services Division (A.F. and D.S.), and BacHBerry FP7-KBBE-2013-613793 (R.M., A.F., C.J., I.C., G.G., R.R.-R., J.P., A.M., C.D., D.S. and C.N.S.). T.F.O. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), and is currently supported by the DFG under Germany’s Excellence Strategy—EXC 2067/1-390729940.Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols' bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin-hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin-hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNMenezes, ReginaFoito, AlexandreJardim, CarolinaCosta, InêsGarcia, GonçaloRosado-Ramos, RitaFreitag, SabineAlexander, Colin JamesOuteiro, Tiago FlemingStewart, DerekSantos, Cláudia N2020-10-13T22:43:52Z2020-092020-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/105560eng2076-3921PURE: 20223695https://doi.org/10.3390/antiox9090789info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:50:46Zoai:run.unl.pt:10362/105560Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:30.983219Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| title |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| spellingShingle |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases Menezes, Regina SDG 3 - Good Health and Well-being |
| title_short |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| title_full |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| title_fullStr |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| title_full_unstemmed |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| title_sort |
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases |
| author |
Menezes, Regina |
| author_facet |
Menezes, Regina Foito, Alexandre Jardim, Carolina Costa, Inês Garcia, Gonçalo Rosado-Ramos, Rita Freitag, Sabine Alexander, Colin James Outeiro, Tiago Fleming Stewart, Derek Santos, Cláudia N |
| author_role |
author |
| author2 |
Foito, Alexandre Jardim, Carolina Costa, Inês Garcia, Gonçalo Rosado-Ramos, Rita Freitag, Sabine Alexander, Colin James Outeiro, Tiago Fleming Stewart, Derek Santos, Cláudia N |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Menezes, Regina Foito, Alexandre Jardim, Carolina Costa, Inês Garcia, Gonçalo Rosado-Ramos, Rita Freitag, Sabine Alexander, Colin James Outeiro, Tiago Fleming Stewart, Derek Santos, Cláudia N |
| dc.subject.por.fl_str_mv |
SDG 3 - Good Health and Well-being |
| topic |
SDG 3 - Good Health and Well-being |
| description |
Funding: iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. This work was supported by Fundação para a Ciência e Tecnologia (IF/01097/2013 to C.N.S.), by The Scottish Government Rural and Environment Science and Analytical Services Division (A.F. and D.S.), and BacHBerry FP7-KBBE-2013-613793 (R.M., A.F., C.J., I.C., G.G., R.R.-R., J.P., A.M., C.D., D.S. and C.N.S.). T.F.O. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), and is currently supported by the DFG under Germany’s Excellence Strategy—EXC 2067/1-390729940. |
| publishDate |
2020 |
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2020-10-13T22:43:52Z 2020-09 2020-09-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/105560 |
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http://hdl.handle.net/10362/105560 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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2076-3921 PURE: 20223695 https://doi.org/10.3390/antiox9090789 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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