New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches

Detalhes bibliográficos
Autor(a) principal: Jorge, Paula Alexandra Silva
Data de Publicação: 2012
Outros Autores: Lourenço, Anália, Pereira, Maria Olívia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/21525
Resumo: Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.
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spelling New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approachesBiofilmAntimicrobial peptideTherapeutic and prophylactic strategiesBioinformaticsAnti-biofilm mechanisms of actionScience & TechnologyAntimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.Financial support from IBB-CEB and Fundacao para a Ciencia e Tecnologia (FCT) and European Community fund FEDER, through Program COMPETE, in the ambit of the FCT project 'PTDC/SAU-SAP/113196/2009/ FCOMP-01-0124-FEDER-016012' is gratefully acknowledged.Taylor and FrancisUniversidade do MinhoJorge, Paula Alexandra SilvaLourenço, AnáliaPereira, Maria Olívia20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21525eng0892-701410.1080/08927014.2012.72821023016989info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:41:51Zoai:repositorium.sdum.uminho.pt:1822/21525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:38:56.793446Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
title New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
spellingShingle New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
Jorge, Paula Alexandra Silva
Biofilm
Antimicrobial peptide
Therapeutic and prophylactic strategies
Bioinformatics
Anti-biofilm mechanisms of action
Science & Technology
title_short New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
title_full New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
title_fullStr New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
title_full_unstemmed New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
title_sort New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
author Jorge, Paula Alexandra Silva
author_facet Jorge, Paula Alexandra Silva
Lourenço, Anália
Pereira, Maria Olívia
author_role author
author2 Lourenço, Anália
Pereira, Maria Olívia
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jorge, Paula Alexandra Silva
Lourenço, Anália
Pereira, Maria Olívia
dc.subject.por.fl_str_mv Biofilm
Antimicrobial peptide
Therapeutic and prophylactic strategies
Bioinformatics
Anti-biofilm mechanisms of action
Science & Technology
topic Biofilm
Antimicrobial peptide
Therapeutic and prophylactic strategies
Bioinformatics
Anti-biofilm mechanisms of action
Science & Technology
description Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/21525
url http://hdl.handle.net/1822/21525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0892-7014
10.1080/08927014.2012.728210
23016989
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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