New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/21525 |
Resumo: | Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing. |
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New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approachesBiofilmAntimicrobial peptideTherapeutic and prophylactic strategiesBioinformaticsAnti-biofilm mechanisms of actionScience & TechnologyAntimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.Financial support from IBB-CEB and Fundacao para a Ciencia e Tecnologia (FCT) and European Community fund FEDER, through Program COMPETE, in the ambit of the FCT project 'PTDC/SAU-SAP/113196/2009/ FCOMP-01-0124-FEDER-016012' is gratefully acknowledged.Taylor and FrancisUniversidade do MinhoJorge, Paula Alexandra SilvaLourenço, AnáliaPereira, Maria Olívia20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21525eng0892-701410.1080/08927014.2012.72821023016989info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:41:51Zoai:repositorium.sdum.uminho.pt:1822/21525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:38:56.793446Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
title |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
spellingShingle |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches Jorge, Paula Alexandra Silva Biofilm Antimicrobial peptide Therapeutic and prophylactic strategies Bioinformatics Anti-biofilm mechanisms of action Science & Technology |
title_short |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
title_full |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
title_fullStr |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
title_full_unstemmed |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
title_sort |
New trends in peptide-based anti-biofilm strategies : a review of recent achievements and bioinformatics approaches |
author |
Jorge, Paula Alexandra Silva |
author_facet |
Jorge, Paula Alexandra Silva Lourenço, Anália Pereira, Maria Olívia |
author_role |
author |
author2 |
Lourenço, Anália Pereira, Maria Olívia |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Jorge, Paula Alexandra Silva Lourenço, Anália Pereira, Maria Olívia |
dc.subject.por.fl_str_mv |
Biofilm Antimicrobial peptide Therapeutic and prophylactic strategies Bioinformatics Anti-biofilm mechanisms of action Science & Technology |
topic |
Biofilm Antimicrobial peptide Therapeutic and prophylactic strategies Bioinformatics Anti-biofilm mechanisms of action Science & Technology |
description |
Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2012-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/21525 |
url |
http://hdl.handle.net/1822/21525 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0892-7014 10.1080/08927014.2012.728210 23016989 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor and Francis |
publisher.none.fl_str_mv |
Taylor and Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132928752484352 |