Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture

Detalhes bibliográficos
Autor(a) principal: Bragança, I.
Data de Publicação: 2016
Outros Autores: Danko, A. S., Pacheco, J., Frascari, D., Delerue-Matos, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/9262
Resumo: Pharmaceutically active compounds (PhACs) are common contaminants found in surface and groundwaters, often due to their inefficient removal from wastewater treatment plants. One way in which these compounds can be removed is via aerobic cometabolism, a process that involves oxygenases produced by microorganisms. Limited work has been done examining the efficacy of cometabolism in the removal of PhACs. Therefore, the aim of this work was to investigate the use of an alkane (pentane) in the aerobic cometabolic transformations of paracetamol, ibuprofen, naproxen, diclofenac, and nimesulide. Both paracetamol and ibuprofen (single aromatic compounds) were readily transformed, withnet specific biodegradationratesequal to 1.6 and 3.2 μmol/gcell/day, respectively. Conversely, the two aromatic ring PhACs showed slower (naproxen and nimesulide) or no transformation (diclofenac). In addition, four of the tested PhACs (ibuprofen, paracetamol, naproxen and nimesulide) did not inhibit pentane uptake.
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spelling Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment CulturePharmaceuticalsAnti-inflammatory pharmaceuticalsAnalgesic pharmaceuticalsAerobic cometabolismBiodegradationPentanePharmaceutically active compounds (PhACs) are common contaminants found in surface and groundwaters, often due to their inefficient removal from wastewater treatment plants. One way in which these compounds can be removed is via aerobic cometabolism, a process that involves oxygenases produced by microorganisms. Limited work has been done examining the efficacy of cometabolism in the removal of PhACs. Therefore, the aim of this work was to investigate the use of an alkane (pentane) in the aerobic cometabolic transformations of paracetamol, ibuprofen, naproxen, diclofenac, and nimesulide. Both paracetamol and ibuprofen (single aromatic compounds) were readily transformed, withnet specific biodegradationratesequal to 1.6 and 3.2 μmol/gcell/day, respectively. Conversely, the two aromatic ring PhACs showed slower (naproxen and nimesulide) or no transformation (diclofenac). In addition, four of the tested PhACs (ibuprofen, paracetamol, naproxen and nimesulide) did not inhibit pentane uptake.Springer VerlagRepositório Científico do Instituto Politécnico do PortoBragança, I.Danko, A. S.Pacheco, J.Frascari, D.Delerue-Matos, Cristina20162116-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/9262eng0049-697910.1007/s11270-016-2933-9metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:50:33Zoai:recipp.ipp.pt:10400.22/9262Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:29:52.749238Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
title Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
spellingShingle Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
Bragança, I.
Pharmaceuticals
Anti-inflammatory pharmaceuticals
Analgesic pharmaceuticals
Aerobic cometabolism
Biodegradation
Pentane
title_short Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
title_full Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
title_fullStr Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
title_full_unstemmed Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
title_sort Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture
author Bragança, I.
author_facet Bragança, I.
Danko, A. S.
Pacheco, J.
Frascari, D.
Delerue-Matos, Cristina
author_role author
author2 Danko, A. S.
Pacheco, J.
Frascari, D.
Delerue-Matos, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Bragança, I.
Danko, A. S.
Pacheco, J.
Frascari, D.
Delerue-Matos, Cristina
dc.subject.por.fl_str_mv Pharmaceuticals
Anti-inflammatory pharmaceuticals
Analgesic pharmaceuticals
Aerobic cometabolism
Biodegradation
Pentane
topic Pharmaceuticals
Anti-inflammatory pharmaceuticals
Analgesic pharmaceuticals
Aerobic cometabolism
Biodegradation
Pentane
description Pharmaceutically active compounds (PhACs) are common contaminants found in surface and groundwaters, often due to their inefficient removal from wastewater treatment plants. One way in which these compounds can be removed is via aerobic cometabolism, a process that involves oxygenases produced by microorganisms. Limited work has been done examining the efficacy of cometabolism in the removal of PhACs. Therefore, the aim of this work was to investigate the use of an alkane (pentane) in the aerobic cometabolic transformations of paracetamol, ibuprofen, naproxen, diclofenac, and nimesulide. Both paracetamol and ibuprofen (single aromatic compounds) were readily transformed, withnet specific biodegradationratesequal to 1.6 and 3.2 μmol/gcell/day, respectively. Conversely, the two aromatic ring PhACs showed slower (naproxen and nimesulide) or no transformation (diclofenac). In addition, four of the tested PhACs (ibuprofen, paracetamol, naproxen and nimesulide) did not inhibit pentane uptake.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2116-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/9262
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dc.language.iso.fl_str_mv eng
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10.1007/s11270-016-2933-9
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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