A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.9/2900 |
Resumo: | The new properties of engineered nanoparticles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applications, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation of nanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles (Aeroxide® P25), two phase composition of anatase (65%) and rutile (35%) with an average particle size value of 27.6±11 nm were used. Results on the EC50 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease (p<0.05) after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed. |
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A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticlesTitanium dioxideNanoparticlesEcotoxicity Enzymatic analysisHistologyTransmission electron microscopy The new properties of engineered nanoparticles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applications, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation of nanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles (Aeroxide® P25), two phase composition of anatase (65%) and rutile (35%) with an average particle size value of 27.6±11 nm were used. Results on the EC50 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease (p<0.05) after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed.SpringerRepositório do LNEGPicado, AnaPaixão, Susana M.Moita, LilianaSilva, LuísDiniz, M. S.Lourenço, JoanaPeres, IsabelCastro, LuísaCorreia, J.B.Pereira, JoanaFerreira, IsabelMatos, A. Alves deBarquinha, PedroMendonça, E.2016-03-23T16:24:39Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.9/2900engPicado, A.; Paixão, S.M.; Moita, L.; [et.al.]. - A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles. In: Frontiers of Environmental Science and Engineering, 2015, Vol. 9, nº 5, p. 793-8032095-220110.1007/s11783-015-0775-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-25T11:17:09Zoai:repositorio.lneg.pt:10400.9/2900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:35:56.575593Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
title |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
spellingShingle |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles Picado, Ana Titanium dioxide Nanoparticles Ecotoxicity Enzymatic analysis Histology Transmission electron microscopy |
title_short |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
title_full |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
title_fullStr |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
title_full_unstemmed |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
title_sort |
A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles |
author |
Picado, Ana |
author_facet |
Picado, Ana Paixão, Susana M. Moita, Liliana Silva, Luís Diniz, M. S. Lourenço, Joana Peres, Isabel Castro, Luísa Correia, J.B. Pereira, Joana Ferreira, Isabel Matos, A. Alves de Barquinha, Pedro Mendonça, E. |
author_role |
author |
author2 |
Paixão, Susana M. Moita, Liliana Silva, Luís Diniz, M. S. Lourenço, Joana Peres, Isabel Castro, Luísa Correia, J.B. Pereira, Joana Ferreira, Isabel Matos, A. Alves de Barquinha, Pedro Mendonça, E. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do LNEG |
dc.contributor.author.fl_str_mv |
Picado, Ana Paixão, Susana M. Moita, Liliana Silva, Luís Diniz, M. S. Lourenço, Joana Peres, Isabel Castro, Luísa Correia, J.B. Pereira, Joana Ferreira, Isabel Matos, A. Alves de Barquinha, Pedro Mendonça, E. |
dc.subject.por.fl_str_mv |
Titanium dioxide Nanoparticles Ecotoxicity Enzymatic analysis Histology Transmission electron microscopy |
topic |
Titanium dioxide Nanoparticles Ecotoxicity Enzymatic analysis Histology Transmission electron microscopy |
description |
The new properties of engineered nanoparticles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applications, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation of nanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles (Aeroxide® P25), two phase composition of anatase (65%) and rutile (35%) with an average particle size value of 27.6±11 nm were used. Results on the EC50 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease (p<0.05) after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2016-03-23T16:24:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.9/2900 |
url |
http://hdl.handle.net/10400.9/2900 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Picado, A.; Paixão, S.M.; Moita, L.; [et.al.]. - A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles. In: Frontiers of Environmental Science and Engineering, 2015, Vol. 9, nº 5, p. 793-803 2095-2201 10.1007/s11783-015-0775-0 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130225207934976 |