Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Filipa
Data de Publicação: 2022
Outros Autores: Romão, Vasco C., Rosa, Sara, Jesus, Kátia, Agua-Doce, Ana, Barreira, Sofia, Martins, Patrícia, Silva, Susana, Nobre, Ema, Bugalho, Maria João, Fonseca, Valter R, Fonseca, João Eurico, Graca, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54926
Resumo: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Autoantibodies are produced within germinal centers (GC), in a process regulated by interactions between B, T follicular helper (Tfh), and T follicular regulatory (Tfr) cells. The GC dysregulation in human autoimmunity has been inferred from circulating cells, albeit with conflicting results due to diverse experimental approaches. We applied a consistent approach to compare circulating Tfr and Tfh subsets in patients with different autoimmune diseases. We recruited 97 participants, including 72 patients with Hashimoto's thyroiditis (HT, n = 18), rheumatoid arthritis (RA, n = 16), or systemic lupus erythematosus (SLE, n = 32), and 31 matched healthy donors (HD). We found that the frequency of circulating T follicular subsets differed across diseases. Patients with HT had an increased frequency of blood Tfh cells (p = 0.0215) and a reduced Tfr/Tfh ratio (p = 0.0338) when compared with HD. This was not observed in patients with systemic autoimmune rheumatic diseases (RA, SLE), who had a reduction in both Tfh (p = 0.0494 and p = 0.0392, respectively) and Tfr (p = 0.0003 and p = 0.0001, respectively) cells, resulting in an unchanged Tfr/Tfh ratio. Activated PD-1+ICOS+Tfh and CD4+PD-1+CXCR5-Tph cells were raised only in patients with SLE (p = 0.0022 and p = 0.0054), without association with disease activity. Our data suggest that GC dysregulation, assessed by T follicular subsets, is not uniform in human autoimmunity. Specific patterns of dysregulation may become potential biomarkers for disease and patient stratification.This work was supported by the Fundação para a Ciência e Tecnologia, Portugal (EJPRD/0003/2019).Springer NatureRepositório da Universidade de LisboaRibeiro, FilipaRomão, Vasco C.Rosa, SaraJesus, KátiaAgua-Doce, AnaBarreira, SofiaMartins, PatríciaSilva, SusanaNobre, EmaBugalho, Maria JoãoFonseca, Valter RFonseca, João EuricoGraca, Luis2022-10-26T15:35:38Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54926engSci Rep. 2022 Oct 21;12(1):1763810.1038/s41598-022-21576-82045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:35Zoai:repositorio.ul.pt:10451/54926Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:39.488494Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
title Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
spellingShingle Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
Ribeiro, Filipa
title_short Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
title_full Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
title_fullStr Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
title_full_unstemmed Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
title_sort Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
author Ribeiro, Filipa
author_facet Ribeiro, Filipa
Romão, Vasco C.
Rosa, Sara
Jesus, Kátia
Agua-Doce, Ana
Barreira, Sofia
Martins, Patrícia
Silva, Susana
Nobre, Ema
Bugalho, Maria João
Fonseca, Valter R
Fonseca, João Eurico
Graca, Luis
author_role author
author2 Romão, Vasco C.
Rosa, Sara
Jesus, Kátia
Agua-Doce, Ana
Barreira, Sofia
Martins, Patrícia
Silva, Susana
Nobre, Ema
Bugalho, Maria João
Fonseca, Valter R
Fonseca, João Eurico
Graca, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Filipa
Romão, Vasco C.
Rosa, Sara
Jesus, Kátia
Agua-Doce, Ana
Barreira, Sofia
Martins, Patrícia
Silva, Susana
Nobre, Ema
Bugalho, Maria João
Fonseca, Valter R
Fonseca, João Eurico
Graca, Luis
description © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-26T15:35:38Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54926
url http://hdl.handle.net/10451/54926
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sci Rep. 2022 Oct 21;12(1):17638
10.1038/s41598-022-21576-8
2045-2322
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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