Management of patients at very high risk of osteoporotic fractures through sequential treatments
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/52194 |
Resumo: | © © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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Management of patients at very high risk of osteoporotic fractures through sequential treatmentsAnabolicAntiresorptiveEpidemiologyFractureImminentOsteoporosis© © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment and a range of effective pharmacological agents. Currently, bone-forming (anabolic) agents, in many countries, are used in those patients who have continued to lose bone mineral density (BMD), patients with multiple subsequent fractures or those who have fractured despite treatment with antiresorptive agents. However, head-to-head data suggest that anabolic agents have greater rapidity and efficacy for fracture risk reduction than do antiresorptive therapies. The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) convened an expert working group to discuss the tools available to identify patients at high risk of fracture, review the evidence for the use of anabolic agents as the initial intervention in patients at highest risk of fracture and consider the sequence of therapy following their use. This position paper sets out the findings of the group and the consequent recommendations. The key conclusion is that the current evidence base supports an "anabolic first" approach in patients found to be at very high risk of fracture, followed by maintenance therapy using an antiresorptive agent, and with the subsequent need for antiosteoporosis therapy addressed over a lifetime horizon.Springer NatureRepositório da Universidade de LisboaCurtis, Elizabeth M.Reginster, Jean-YvesAl-Daghri, NasserBiver, EmmanuelBrandi, Maria LuisaCavalier, EtienneHadji, PeymanHalbout, PhilippeHarvey, Nicholas C.Hiligsmann, MickaëlJavaid, M. KassimKanis, John A.Kaufman, Jean-MarcLamy, OlivierMatijevic, RadmilaPerez, Adolfo DiezRadermecker, Régis PierreRosa, Mário MiguelThomas, ThierryThomasius, FriederikeVlaskovska, MilaRizzoli, RenéCooper, Cyrus2022-04-05T14:57:10Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52194engAging Clin Exp Res. 2022 Mar 241594-066710.1007/s40520-022-02100-41720-8319info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:18Zoai:repositorio.ul.pt:10451/52194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:21.703370Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
title |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
spellingShingle |
Management of patients at very high risk of osteoporotic fractures through sequential treatments Curtis, Elizabeth M. Anabolic Antiresorptive Epidemiology Fracture Imminent Osteoporosis |
title_short |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
title_full |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
title_fullStr |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
title_full_unstemmed |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
title_sort |
Management of patients at very high risk of osteoporotic fractures through sequential treatments |
author |
Curtis, Elizabeth M. |
author_facet |
Curtis, Elizabeth M. Reginster, Jean-Yves Al-Daghri, Nasser Biver, Emmanuel Brandi, Maria Luisa Cavalier, Etienne Hadji, Peyman Halbout, Philippe Harvey, Nicholas C. Hiligsmann, Mickaël Javaid, M. Kassim Kanis, John A. Kaufman, Jean-Marc Lamy, Olivier Matijevic, Radmila Perez, Adolfo Diez Radermecker, Régis Pierre Rosa, Mário Miguel Thomas, Thierry Thomasius, Friederike Vlaskovska, Mila Rizzoli, René Cooper, Cyrus |
author_role |
author |
author2 |
Reginster, Jean-Yves Al-Daghri, Nasser Biver, Emmanuel Brandi, Maria Luisa Cavalier, Etienne Hadji, Peyman Halbout, Philippe Harvey, Nicholas C. Hiligsmann, Mickaël Javaid, M. Kassim Kanis, John A. Kaufman, Jean-Marc Lamy, Olivier Matijevic, Radmila Perez, Adolfo Diez Radermecker, Régis Pierre Rosa, Mário Miguel Thomas, Thierry Thomasius, Friederike Vlaskovska, Mila Rizzoli, René Cooper, Cyrus |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Curtis, Elizabeth M. Reginster, Jean-Yves Al-Daghri, Nasser Biver, Emmanuel Brandi, Maria Luisa Cavalier, Etienne Hadji, Peyman Halbout, Philippe Harvey, Nicholas C. Hiligsmann, Mickaël Javaid, M. Kassim Kanis, John A. Kaufman, Jean-Marc Lamy, Olivier Matijevic, Radmila Perez, Adolfo Diez Radermecker, Régis Pierre Rosa, Mário Miguel Thomas, Thierry Thomasius, Friederike Vlaskovska, Mila Rizzoli, René Cooper, Cyrus |
dc.subject.por.fl_str_mv |
Anabolic Antiresorptive Epidemiology Fracture Imminent Osteoporosis |
topic |
Anabolic Antiresorptive Epidemiology Fracture Imminent Osteoporosis |
description |
© © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-05T14:57:10Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/52194 |
url |
http://hdl.handle.net/10451/52194 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Aging Clin Exp Res. 2022 Mar 24 1594-0667 10.1007/s40520-022-02100-4 1720-8319 |
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openAccess |
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Springer Nature |
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Springer Nature |
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