Management of patients at very high risk of osteoporotic fractures through sequential treatments

Detalhes bibliográficos
Autor(a) principal: Curtis, Elizabeth M.
Data de Publicação: 2022
Outros Autores: Reginster, Jean-Yves, Al-Daghri, Nasser, Biver, Emmanuel, Brandi, Maria Luisa, Cavalier, Etienne, Hadji, Peyman, Halbout, Philippe, Harvey, Nicholas C., Hiligsmann, Mickaël, Javaid, M. Kassim, Kanis, John A., Kaufman, Jean-Marc, Lamy, Olivier, Matijevic, Radmila, Perez, Adolfo Diez, Radermecker, Régis Pierre, Rosa, Mário Miguel, Thomas, Thierry, Thomasius, Friederike, Vlaskovska, Mila, Rizzoli, René, Cooper, Cyrus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52194
Resumo: © © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Management of patients at very high risk of osteoporotic fractures through sequential treatmentsAnabolicAntiresorptiveEpidemiologyFractureImminentOsteoporosis© © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment and a range of effective pharmacological agents. Currently, bone-forming (anabolic) agents, in many countries, are used in those patients who have continued to lose bone mineral density (BMD), patients with multiple subsequent fractures or those who have fractured despite treatment with antiresorptive agents. However, head-to-head data suggest that anabolic agents have greater rapidity and efficacy for fracture risk reduction than do antiresorptive therapies. The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) convened an expert working group to discuss the tools available to identify patients at high risk of fracture, review the evidence for the use of anabolic agents as the initial intervention in patients at highest risk of fracture and consider the sequence of therapy following their use. This position paper sets out the findings of the group and the consequent recommendations. The key conclusion is that the current evidence base supports an "anabolic first" approach in patients found to be at very high risk of fracture, followed by maintenance therapy using an antiresorptive agent, and with the subsequent need for antiosteoporosis therapy addressed over a lifetime horizon.Springer NatureRepositório da Universidade de LisboaCurtis, Elizabeth M.Reginster, Jean-YvesAl-Daghri, NasserBiver, EmmanuelBrandi, Maria LuisaCavalier, EtienneHadji, PeymanHalbout, PhilippeHarvey, Nicholas C.Hiligsmann, MickaëlJavaid, M. KassimKanis, John A.Kaufman, Jean-MarcLamy, OlivierMatijevic, RadmilaPerez, Adolfo DiezRadermecker, Régis PierreRosa, Mário MiguelThomas, ThierryThomasius, FriederikeVlaskovska, MilaRizzoli, RenéCooper, Cyrus2022-04-05T14:57:10Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52194engAging Clin Exp Res. 2022 Mar 241594-066710.1007/s40520-022-02100-41720-8319info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:18Zoai:repositorio.ul.pt:10451/52194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:21.703370Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Management of patients at very high risk of osteoporotic fractures through sequential treatments
title Management of patients at very high risk of osteoporotic fractures through sequential treatments
spellingShingle Management of patients at very high risk of osteoporotic fractures through sequential treatments
Curtis, Elizabeth M.
Anabolic
Antiresorptive
Epidemiology
Fracture
Imminent
Osteoporosis
title_short Management of patients at very high risk of osteoporotic fractures through sequential treatments
title_full Management of patients at very high risk of osteoporotic fractures through sequential treatments
title_fullStr Management of patients at very high risk of osteoporotic fractures through sequential treatments
title_full_unstemmed Management of patients at very high risk of osteoporotic fractures through sequential treatments
title_sort Management of patients at very high risk of osteoporotic fractures through sequential treatments
author Curtis, Elizabeth M.
author_facet Curtis, Elizabeth M.
Reginster, Jean-Yves
Al-Daghri, Nasser
Biver, Emmanuel
Brandi, Maria Luisa
Cavalier, Etienne
Hadji, Peyman
Halbout, Philippe
Harvey, Nicholas C.
Hiligsmann, Mickaël
Javaid, M. Kassim
Kanis, John A.
Kaufman, Jean-Marc
Lamy, Olivier
Matijevic, Radmila
Perez, Adolfo Diez
Radermecker, Régis Pierre
Rosa, Mário Miguel
Thomas, Thierry
Thomasius, Friederike
Vlaskovska, Mila
Rizzoli, René
Cooper, Cyrus
author_role author
author2 Reginster, Jean-Yves
Al-Daghri, Nasser
Biver, Emmanuel
Brandi, Maria Luisa
Cavalier, Etienne
Hadji, Peyman
Halbout, Philippe
Harvey, Nicholas C.
Hiligsmann, Mickaël
Javaid, M. Kassim
Kanis, John A.
Kaufman, Jean-Marc
Lamy, Olivier
Matijevic, Radmila
Perez, Adolfo Diez
Radermecker, Régis Pierre
Rosa, Mário Miguel
Thomas, Thierry
Thomasius, Friederike
Vlaskovska, Mila
Rizzoli, René
Cooper, Cyrus
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Curtis, Elizabeth M.
Reginster, Jean-Yves
Al-Daghri, Nasser
Biver, Emmanuel
Brandi, Maria Luisa
Cavalier, Etienne
Hadji, Peyman
Halbout, Philippe
Harvey, Nicholas C.
Hiligsmann, Mickaël
Javaid, M. Kassim
Kanis, John A.
Kaufman, Jean-Marc
Lamy, Olivier
Matijevic, Radmila
Perez, Adolfo Diez
Radermecker, Régis Pierre
Rosa, Mário Miguel
Thomas, Thierry
Thomasius, Friederike
Vlaskovska, Mila
Rizzoli, René
Cooper, Cyrus
dc.subject.por.fl_str_mv Anabolic
Antiresorptive
Epidemiology
Fracture
Imminent
Osteoporosis
topic Anabolic
Antiresorptive
Epidemiology
Fracture
Imminent
Osteoporosis
description © © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-05T14:57:10Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52194
url http://hdl.handle.net/10451/52194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Aging Clin Exp Res. 2022 Mar 24
1594-0667
10.1007/s40520-022-02100-4
1720-8319
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
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