Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Fernanda
Data de Publicação: 2019
Outros Autores: Christensen, Hannah, Morales-Aza, Begonia, Sikora, Paulina, Oliver, Elizabeth, Oliver, Jennifer, Lucidarme, Jay, Marlow, Robin, Januário, Luís, Finn, Adam
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/107302
https://doi.org/10.1371/journal.pone.0209905
Resumo: Improved sensitivity and efficiency of detection and quantification of carriage of Neisseria meningitidis (Nm) in young people is important for evaluation of the impact of vaccines upon transmission and associated population-wide effects. Saliva collection is quick, non-invasive and facilitates frequent sampling, but has been reported to yield low sensitivity by culture. We re-evaluated this approach in a follow-up cross sectional study using direct and culture-amplified PCR.
id RCAP_7b743918208ad5be269c874499a584f9
oai_identifier_str oai:estudogeral.uc.pt:10316/107302
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese studentsAdolescentAdultAge FactorsCarrier StateCross-Sectional StudiesHumansMeningitis, MeningococcalMiddle AgedNeisseria meningitidisPolymerase Chain ReactionPortugalSalivaYoung AdultImproved sensitivity and efficiency of detection and quantification of carriage of Neisseria meningitidis (Nm) in young people is important for evaluation of the impact of vaccines upon transmission and associated population-wide effects. Saliva collection is quick, non-invasive and facilitates frequent sampling, but has been reported to yield low sensitivity by culture. We re-evaluated this approach in a follow-up cross sectional study using direct and culture-amplified PCR.Public Library of Science2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107302http://hdl.handle.net/10316/107302https://doi.org/10.1371/journal.pone.0209905eng1932-6203Rodrigues, FernandaChristensen, HannahMorales-Aza, BegoniaSikora, PaulinaOliver, ElizabethOliver, JenniferLucidarme, JayMarlow, RobinJanuário, LuísFinn, Adaminfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-03T08:10:14Zoai:estudogeral.uc.pt:10316/107302Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:40.508765Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
title Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
spellingShingle Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
Rodrigues, Fernanda
Adolescent
Adult
Age Factors
Carrier State
Cross-Sectional Studies
Humans
Meningitis, Meningococcal
Middle Aged
Neisseria meningitidis
Polymerase Chain Reaction
Portugal
Saliva
Young Adult
title_short Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
title_full Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
title_fullStr Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
title_full_unstemmed Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
title_sort Viable Neisseria meningitidis is commonly present in saliva in healthy young adults: Non-invasive sampling and enhanced sensitivity of detection in a follow-up carriage study in Portuguese students
author Rodrigues, Fernanda
author_facet Rodrigues, Fernanda
Christensen, Hannah
Morales-Aza, Begonia
Sikora, Paulina
Oliver, Elizabeth
Oliver, Jennifer
Lucidarme, Jay
Marlow, Robin
Januário, Luís
Finn, Adam
author_role author
author2 Christensen, Hannah
Morales-Aza, Begonia
Sikora, Paulina
Oliver, Elizabeth
Oliver, Jennifer
Lucidarme, Jay
Marlow, Robin
Januário, Luís
Finn, Adam
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Fernanda
Christensen, Hannah
Morales-Aza, Begonia
Sikora, Paulina
Oliver, Elizabeth
Oliver, Jennifer
Lucidarme, Jay
Marlow, Robin
Januário, Luís
Finn, Adam
dc.subject.por.fl_str_mv Adolescent
Adult
Age Factors
Carrier State
Cross-Sectional Studies
Humans
Meningitis, Meningococcal
Middle Aged
Neisseria meningitidis
Polymerase Chain Reaction
Portugal
Saliva
Young Adult
topic Adolescent
Adult
Age Factors
Carrier State
Cross-Sectional Studies
Humans
Meningitis, Meningococcal
Middle Aged
Neisseria meningitidis
Polymerase Chain Reaction
Portugal
Saliva
Young Adult
description Improved sensitivity and efficiency of detection and quantification of carriage of Neisseria meningitidis (Nm) in young people is important for evaluation of the impact of vaccines upon transmission and associated population-wide effects. Saliva collection is quick, non-invasive and facilitates frequent sampling, but has been reported to yield low sensitivity by culture. We re-evaluated this approach in a follow-up cross sectional study using direct and culture-amplified PCR.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107302
http://hdl.handle.net/10316/107302
https://doi.org/10.1371/journal.pone.0209905
url http://hdl.handle.net/10316/107302
https://doi.org/10.1371/journal.pone.0209905
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134123054333952

Registros relacionados