Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109786 https://doi.org/10.1371/journal.pone.0074798 |
Resumo: | Meningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenetic and gene expression profile (GEP) of 75 meningioma patients. Overall, our results showed a close association between the amount and cellular composition of the inflammatory and other immune cell infiltrates and the cytogenetic profile of the tumors. Notably, tumors with isolated monosomy 22/del(22q) showed greater numbers of TiMa, NK cells and (recently)-activated CD69(+) lymphocytes versus meningiomas with diploid and complex karyotypes. In addition, in the former cytogenetic subgroup of meningiomas, tumor-infiltrating TiMa also showed a more activated and functionally mature phenotype, as reflected by a greater fraction of CD69(+), CD63(+), CD16(+) and CD33(+) cells. GEP at the mRNA level showed a unique GEP among meningiomas with an isolated monosomy 22/del(22q) versus all other cases, which consisted of increased expression of genes involved in inflammatory/immune response, associated with an M1 TiMa phenotype. Altogether, these results suggest that loss of expression of specific genes coded in chromosome 22 (e.g. MIF) is closely associated with an increased homing and potentially also anti-tumoral effect of TiMa, which could contribute to explain the better outcome of this specific good-prognosis cytogenetic subgroup of meningiomas. |
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Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomasAdultAgedAged, 80 and overAntigen-Presenting CellsChromosomes, Human, Pair 22FemaleHumansInflammationKaryotypeLymphocytesMaleMeningeal NeoplasmsMeningiomaMiddle AgedTranscriptomeYoung AdultChromosome DeletionMeningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenetic and gene expression profile (GEP) of 75 meningioma patients. Overall, our results showed a close association between the amount and cellular composition of the inflammatory and other immune cell infiltrates and the cytogenetic profile of the tumors. Notably, tumors with isolated monosomy 22/del(22q) showed greater numbers of TiMa, NK cells and (recently)-activated CD69(+) lymphocytes versus meningiomas with diploid and complex karyotypes. In addition, in the former cytogenetic subgroup of meningiomas, tumor-infiltrating TiMa also showed a more activated and functionally mature phenotype, as reflected by a greater fraction of CD69(+), CD63(+), CD16(+) and CD33(+) cells. GEP at the mRNA level showed a unique GEP among meningiomas with an isolated monosomy 22/del(22q) versus all other cases, which consisted of increased expression of genes involved in inflammatory/immune response, associated with an M1 TiMa phenotype. Altogether, these results suggest that loss of expression of specific genes coded in chromosome 22 (e.g. MIF) is closely associated with an increased homing and potentially also anti-tumoral effect of TiMa, which could contribute to explain the better outcome of this specific good-prognosis cytogenetic subgroup of meningiomas.Public Library of Science2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109786http://hdl.handle.net/10316/109786https://doi.org/10.1371/journal.pone.0074798eng1932-6203Domingues, Patrícia HenriquesTeodósio, CristinaOtero, ÁlvaroSousa, PabloOrtiz, JavierMacias, María del Carmen GarcíaGonçalves, Jesús MaríaNieto, Ana BelénLopes, Maria CelesteOliveira, Catarina deOrfão, AlbertoTabernero, María Doloresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-26T10:37:38Zoai:estudogeral.uc.pt:10316/109786Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:56.052486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
title |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
spellingShingle |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas Domingues, Patrícia Henriques Adult Aged Aged, 80 and over Antigen-Presenting Cells Chromosomes, Human, Pair 22 Female Humans Inflammation Karyotype Lymphocytes Male Meningeal Neoplasms Meningioma Middle Aged Transcriptome Young Adult Chromosome Deletion |
title_short |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
title_full |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
title_fullStr |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
title_full_unstemmed |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
title_sort |
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas |
author |
Domingues, Patrícia Henriques |
author_facet |
Domingues, Patrícia Henriques Teodósio, Cristina Otero, Álvaro Sousa, Pablo Ortiz, Javier Macias, María del Carmen García Gonçalves, Jesús María Nieto, Ana Belén Lopes, Maria Celeste Oliveira, Catarina de Orfão, Alberto Tabernero, María Dolores |
author_role |
author |
author2 |
Teodósio, Cristina Otero, Álvaro Sousa, Pablo Ortiz, Javier Macias, María del Carmen García Gonçalves, Jesús María Nieto, Ana Belén Lopes, Maria Celeste Oliveira, Catarina de Orfão, Alberto Tabernero, María Dolores |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Domingues, Patrícia Henriques Teodósio, Cristina Otero, Álvaro Sousa, Pablo Ortiz, Javier Macias, María del Carmen García Gonçalves, Jesús María Nieto, Ana Belén Lopes, Maria Celeste Oliveira, Catarina de Orfão, Alberto Tabernero, María Dolores |
dc.subject.por.fl_str_mv |
Adult Aged Aged, 80 and over Antigen-Presenting Cells Chromosomes, Human, Pair 22 Female Humans Inflammation Karyotype Lymphocytes Male Meningeal Neoplasms Meningioma Middle Aged Transcriptome Young Adult Chromosome Deletion |
topic |
Adult Aged Aged, 80 and over Antigen-Presenting Cells Chromosomes, Human, Pair 22 Female Humans Inflammation Karyotype Lymphocytes Male Meningeal Neoplasms Meningioma Middle Aged Transcriptome Young Adult Chromosome Deletion |
description |
Meningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenetic and gene expression profile (GEP) of 75 meningioma patients. Overall, our results showed a close association between the amount and cellular composition of the inflammatory and other immune cell infiltrates and the cytogenetic profile of the tumors. Notably, tumors with isolated monosomy 22/del(22q) showed greater numbers of TiMa, NK cells and (recently)-activated CD69(+) lymphocytes versus meningiomas with diploid and complex karyotypes. In addition, in the former cytogenetic subgroup of meningiomas, tumor-infiltrating TiMa also showed a more activated and functionally mature phenotype, as reflected by a greater fraction of CD69(+), CD63(+), CD16(+) and CD33(+) cells. GEP at the mRNA level showed a unique GEP among meningiomas with an isolated monosomy 22/del(22q) versus all other cases, which consisted of increased expression of genes involved in inflammatory/immune response, associated with an M1 TiMa phenotype. Altogether, these results suggest that loss of expression of specific genes coded in chromosome 22 (e.g. MIF) is closely associated with an increased homing and potentially also anti-tumoral effect of TiMa, which could contribute to explain the better outcome of this specific good-prognosis cytogenetic subgroup of meningiomas. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109786 http://hdl.handle.net/10316/109786 https://doi.org/10.1371/journal.pone.0074798 |
url |
http://hdl.handle.net/10316/109786 https://doi.org/10.1371/journal.pone.0074798 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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