Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/23189 |
Resumo: | The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated this issue by studying how neural circuits in the frontal cortex determine action timing in rats performing a waiting task. Electrophysiological recordings from two regions necessary for this behavior, medial prefrontal cortex (mPFC) and secondary motor cortex (M2), revealed an unexpected functional dissociation. Both areas encoded deterministic biases in action timing, but only M2 neurons reflected stochastic trial-by-trial fluctuations. This differential coding was reflected in distinct timescales of neural dynamics in the two frontal cortical areas. These results suggest a two-stage model in which stochastic components of action timing decisions are injected by circuits downstream of those carrying deterministic bias signals. |
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Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal CortexBehavior, AnimalDecision MakingMotor CortexPrefrontal CortexThe selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated this issue by studying how neural circuits in the frontal cortex determine action timing in rats performing a waiting task. Electrophysiological recordings from two regions necessary for this behavior, medial prefrontal cortex (mPFC) and secondary motor cortex (M2), revealed an unexpected functional dissociation. Both areas encoded deterministic biases in action timing, but only M2 neurons reflected stochastic trial-by-trial fluctuations. This differential coding was reflected in distinct timescales of neural dynamics in the two frontal cortical areas. These results suggest a two-stage model in which stochastic components of action timing decisions are injected by circuits downstream of those carrying deterministic bias signals.ERC 20334, 5-HT OptogeneticERC 671251, 5-HT CircuitsNeuronRepositório ComumMurakami, MasayoshiShteingart, HananLoewenstein, YonatanMainen, Zachary F.2018-06-29T14:31:26Z2017-05-172017-05-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/23189eng10.1016/j.neuron.2017.04.040info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-26T17:15:12Zoai:comum.rcaap.pt:10400.26/23189Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:49:01.081071Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
title |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
spellingShingle |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex Murakami, Masayoshi Behavior, Animal Decision Making Motor Cortex Prefrontal Cortex |
title_short |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
title_full |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
title_fullStr |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
title_full_unstemmed |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
title_sort |
Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex |
author |
Murakami, Masayoshi |
author_facet |
Murakami, Masayoshi Shteingart, Hanan Loewenstein, Yonatan Mainen, Zachary F. |
author_role |
author |
author2 |
Shteingart, Hanan Loewenstein, Yonatan Mainen, Zachary F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Murakami, Masayoshi Shteingart, Hanan Loewenstein, Yonatan Mainen, Zachary F. |
dc.subject.por.fl_str_mv |
Behavior, Animal Decision Making Motor Cortex Prefrontal Cortex |
topic |
Behavior, Animal Decision Making Motor Cortex Prefrontal Cortex |
description |
The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated this issue by studying how neural circuits in the frontal cortex determine action timing in rats performing a waiting task. Electrophysiological recordings from two regions necessary for this behavior, medial prefrontal cortex (mPFC) and secondary motor cortex (M2), revealed an unexpected functional dissociation. Both areas encoded deterministic biases in action timing, but only M2 neurons reflected stochastic trial-by-trial fluctuations. This differential coding was reflected in distinct timescales of neural dynamics in the two frontal cortical areas. These results suggest a two-stage model in which stochastic components of action timing decisions are injected by circuits downstream of those carrying deterministic bias signals. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-17 2017-05-17T00:00:00Z 2018-06-29T14:31:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/23189 |
url |
http://hdl.handle.net/10400.26/23189 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.neuron.2017.04.040 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Neuron |
publisher.none.fl_str_mv |
Neuron |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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