Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles

Detalhes bibliográficos
Autor(a) principal: Roma-Rodrigues, Catarina
Data de Publicação: 2019
Outros Autores: Fernandes, Alexandra R., Baptista, Pedro V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/104546
Resumo: FCT/MCTES - UID/Multi/04378/2019. FCT/MCTES - SFRH/BPD/124612/2016.
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spelling Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticlesAngiogenesisChorioallantoic membraneChronic myeloid leukemiaExosomesGold nanoparticlesBiophysicsBioengineeringBiomaterialsPharmaceutical ScienceDrug DiscoveryOrganic ChemistrySDG 3 - Good Health and Well-beingFCT/MCTES - UID/Multi/04378/2019. FCT/MCTES - SFRH/BPD/124612/2016.Purpose: Progression of chronic myeloid leukemia (CML) is frequently associated with increased angiogenesis at the bone marrow mediated by exosomes. The capability of gold nanoparticles (AuNPs) functionalized with antiangiogenic peptides to hinder the formation of new blood vessels has been demonstrated in a chorioallantoic membrane (CAM) model. Methods: Exosomes of K562 CML cell line were isolated and their angiogenic effect assessed in a CAM model. AuNPs functionalized with antiangiogenic peptides were used to block the angiogenic effect of CML-derived exosomes, assessed by evaluation of expression levels of key modulators involved in angiogenic pathways - VEGFA, VEGFR1 (also known as FLT1) and IL8. Results: Exosomes isolated from K562 cells promoted the doubling of newly formed vessels associated with the increase of VEGFR1 expression. This is a concentration and timedependent effect. The AuNPs functionalized with antiangiogenic peptides were capable to block the angiogenic effect by modulating VEGFR1 associated pathway. Conclusion: Exosomes derived from blast cells are capable to trigger (neo)-angiogenesis, a key factor for the progression and spreading of cancer, in particular in CML. AuNPs functionalized with specific antiangiogenic peptides are capable to block the effect of the exosomes produced by malignant cells via modulation of the intrinsic VEGFR pathway. Together, these data highlight the potential of nanomedicine-based strategies against cancer proliferation.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNRoma-Rodrigues, CatarinaFernandes, Alexandra R.Baptista, Pedro V.2020-09-22T22:15:42Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/104546eng1176-9114PURE: 18997067https://doi.org/10.2147/IJN.S215711info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:50:04Zoai:run.unl.pt:10362/104546Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:15.866012Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
title Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
spellingShingle Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
Roma-Rodrigues, Catarina
Angiogenesis
Chorioallantoic membrane
Chronic myeloid leukemia
Exosomes
Gold nanoparticles
Biophysics
Bioengineering
Biomaterials
Pharmaceutical Science
Drug Discovery
Organic Chemistry
SDG 3 - Good Health and Well-being
title_short Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
title_full Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
title_fullStr Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
title_full_unstemmed Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
title_sort Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
author Roma-Rodrigues, Catarina
author_facet Roma-Rodrigues, Catarina
Fernandes, Alexandra R.
Baptista, Pedro V.
author_role author
author2 Fernandes, Alexandra R.
Baptista, Pedro V.
author2_role author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Roma-Rodrigues, Catarina
Fernandes, Alexandra R.
Baptista, Pedro V.
dc.subject.por.fl_str_mv Angiogenesis
Chorioallantoic membrane
Chronic myeloid leukemia
Exosomes
Gold nanoparticles
Biophysics
Bioengineering
Biomaterials
Pharmaceutical Science
Drug Discovery
Organic Chemistry
SDG 3 - Good Health and Well-being
topic Angiogenesis
Chorioallantoic membrane
Chronic myeloid leukemia
Exosomes
Gold nanoparticles
Biophysics
Bioengineering
Biomaterials
Pharmaceutical Science
Drug Discovery
Organic Chemistry
SDG 3 - Good Health and Well-being
description FCT/MCTES - UID/Multi/04378/2019. FCT/MCTES - SFRH/BPD/124612/2016.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-09-22T22:15:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/104546
url http://hdl.handle.net/10362/104546
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1176-9114
PURE: 18997067
https://doi.org/10.2147/IJN.S215711
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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