BRAF L597K mutation: an opportunity to treat

Detalhes bibliográficos
Autor(a) principal: Lobo-Martins, Soraia
Data de Publicação: 2021
Outros Autores: Pais, Helena Luna, Soares-de-Almeida, Luís, Costa, Luis, Mansinho, André, Sousa, Rita Teixeira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54631
Resumo: © Copyright 2021 by the author(s).This work is made available under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives License, available at https://creativecommons.org/licenses/by-nc-nd/4.0/
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spelling BRAF L597K mutation: an opportunity to treatMetastatic melanomaNon-V600 BRAF mutationTarget therapy© Copyright 2021 by the author(s).This work is made available under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives License, available at https://creativecommons.org/licenses/by-nc-nd/4.0/The outcomes of patients with metastatic melanoma (MM) have significantly improved after the introduction of BRAF-specific inhibitors. Herein is reported a patient with MM and non-V600-BRAF mutation who responded to iBRAF/iMEK therapy. In July 2014, a 63-year-old man presented with a 4.1mm-thick V600E-BRAF wild type melanoma on the back. Metastases were identified in one sentinel node and two of 11 subsequently excised lymph nodes, with no signs of distant metastatic disease. In September 2017, lung metastasis was observed and pembrolizumab was started. Progressive disease was apparent at cycle 10 and therapy was switched to ipilimumab. After four cycles, an asymmetric response was observed. In November 2017, next generation sequencing genomic profiling disclosed a rare L597K-BRAF mutation and vemurafenib plus cobimetinib therapy was initiated in January 2018. Seven days after treatment start, a remarkable clinical improvement was observed. In April 2018, the patient achieved partial response, which was sustained until October 2018. Cases of patients with non-V600-BRAF mutations responding to iBRAF/iMEK therapy have been reported over the last years. To the best of our knowledge, this is the first case reporting response to combined iBRAF/iMEK therapy in a patient with metastatic melanoma harboring L597K mutation.eScholarship PublishingRepositório da Universidade de LisboaLobo-Martins, SoraiaPais, Helena LunaSoares-de-Almeida, LuísCosta, LuisMansinho, AndréSousa, Rita Teixeira de2022-09-29T14:35:04Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54631engDermatol Online J. 2021 Jan 15;27(1):13030/qt18k3573s10.5070/D32710520291087-2108info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:06Zoai:repositorio.ul.pt:10451/54631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:25.406897Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv BRAF L597K mutation: an opportunity to treat
title BRAF L597K mutation: an opportunity to treat
spellingShingle BRAF L597K mutation: an opportunity to treat
Lobo-Martins, Soraia
Metastatic melanoma
Non-V600 BRAF mutation
Target therapy
title_short BRAF L597K mutation: an opportunity to treat
title_full BRAF L597K mutation: an opportunity to treat
title_fullStr BRAF L597K mutation: an opportunity to treat
title_full_unstemmed BRAF L597K mutation: an opportunity to treat
title_sort BRAF L597K mutation: an opportunity to treat
author Lobo-Martins, Soraia
author_facet Lobo-Martins, Soraia
Pais, Helena Luna
Soares-de-Almeida, Luís
Costa, Luis
Mansinho, André
Sousa, Rita Teixeira de
author_role author
author2 Pais, Helena Luna
Soares-de-Almeida, Luís
Costa, Luis
Mansinho, André
Sousa, Rita Teixeira de
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Lobo-Martins, Soraia
Pais, Helena Luna
Soares-de-Almeida, Luís
Costa, Luis
Mansinho, André
Sousa, Rita Teixeira de
dc.subject.por.fl_str_mv Metastatic melanoma
Non-V600 BRAF mutation
Target therapy
topic Metastatic melanoma
Non-V600 BRAF mutation
Target therapy
description © Copyright 2021 by the author(s).This work is made available under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives License, available at https://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-09-29T14:35:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54631
url http://hdl.handle.net/10451/54631
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dermatol Online J. 2021 Jan 15;27(1):13030/qt18k3573s
10.5070/D3271052029
1087-2108
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv eScholarship Publishing
publisher.none.fl_str_mv eScholarship Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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