Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential

Detalhes bibliográficos
Autor(a) principal: Brito, Dulce
Data de Publicação: 2020
Outros Autores: Bettencourt, Paulo, Carvalho, Davide, Ferreira, Jorge, Fontes-Carvalho, Ricardo, Franco, Fátima, Moura, Brenda, Silva-Cardoso, José Carlos, Melo, Rachel Tavares de, Fonseca, Cândida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/43484
Resumo: © The Author(s) 2020
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spelling Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potentialSGLT2iDiabetesHeart failureCardiovascular riskCardiovascular outcomes trials© The Author(s) 2020Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a new drug class designed to treat patients with type 2 diabetes (T2D). However, cardiovascular outcome trials showed that SGLT2i also offer protection against heart failure (HF)–related events and cardiovascular mortality. These benefits appear to be independent of glycaemic control and have recently been demonstrated in the HF population with reduced ejection fraction (HFrEF), with or without T2D. This comprehensive, evidence-based review focuses on the published studies concerning HF outcomes with SGLT2i, discussing issues that may underlie the different results, along with the impact of these new drugs in clinical practice. The potential translational mechanisms behind SGLT2i cardio-renal benefits and the information that ongoing studies may add to the already existing body of evidence are also reviewed. Finally, we focus on practical management issues regarding SGLT2i use in association with other T2D and HFrEF common pharmacological therapies. Safety considerations are also highlighted. Considering the paradigm shift in T2D management, from a focus on glycaemic control to a broader approach on cardiovascular protection and event reduction, including the potential for wide SGLT2i implementation in HF patients, with or without T2D, we are facing a promising time for major changes in the global management of cardiovascular disease.This paper had a non-restrictive financial support of Boehringer Ingelheim and Lilly Portugal.Springer NatureRepositório da Universidade de LisboaBrito, DulceBettencourt, PauloCarvalho, DavideFerreira, JorgeFontes-Carvalho, RicardoFranco, FátimaMoura, BrendaSilva-Cardoso, José CarlosMelo, Rachel Tavares deFonseca, Cândida2020-05-05T10:54:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/43484engCardiovasc Drugs Ther (2020)0920-320610.1007/s10557-020-06973-31573-7241info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:43:59Zoai:repositorio.ul.pt:10451/43484Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:56:16.978306Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
title Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
spellingShingle Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
Brito, Dulce
SGLT2i
Diabetes
Heart failure
Cardiovascular risk
Cardiovascular outcomes trials
title_short Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
title_full Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
title_fullStr Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
title_full_unstemmed Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
title_sort Sodium-glucose co-transporter 2 inhibitors in the failing heart : a growing potential
author Brito, Dulce
author_facet Brito, Dulce
Bettencourt, Paulo
Carvalho, Davide
Ferreira, Jorge
Fontes-Carvalho, Ricardo
Franco, Fátima
Moura, Brenda
Silva-Cardoso, José Carlos
Melo, Rachel Tavares de
Fonseca, Cândida
author_role author
author2 Bettencourt, Paulo
Carvalho, Davide
Ferreira, Jorge
Fontes-Carvalho, Ricardo
Franco, Fátima
Moura, Brenda
Silva-Cardoso, José Carlos
Melo, Rachel Tavares de
Fonseca, Cândida
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Brito, Dulce
Bettencourt, Paulo
Carvalho, Davide
Ferreira, Jorge
Fontes-Carvalho, Ricardo
Franco, Fátima
Moura, Brenda
Silva-Cardoso, José Carlos
Melo, Rachel Tavares de
Fonseca, Cândida
dc.subject.por.fl_str_mv SGLT2i
Diabetes
Heart failure
Cardiovascular risk
Cardiovascular outcomes trials
topic SGLT2i
Diabetes
Heart failure
Cardiovascular risk
Cardiovascular outcomes trials
description © The Author(s) 2020
publishDate 2020
dc.date.none.fl_str_mv 2020-05-05T10:54:14Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/43484
url http://hdl.handle.net/10451/43484
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cardiovasc Drugs Ther (2020)
0920-3206
10.1007/s10557-020-06973-3
1573-7241
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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