Basics of drug transport & delivery and radiopharmacy for nuclear medical applications
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://proa.ua.pt/index.php/revdeti/article/view/17130 |
Resumo: | Radiopharmaceuticals are pharmaceutical substances which contain a radionuclide within their structure, not eliciting any physiological response. Radiopharmaceuticals can be used as imaging agents, function agents, in vitro studies and therapeutical agents. There are several criteria for radionuclide selection concerning in vivo applications: half-life, radiotoxicity, purity, specific activity, accessibility vs production cost. The design of radiopharmaceuticals is based upon physiological function of the target organ. The mechanism of localization of a radiopharmaceutical in a particular target organ depends on many processes: antigen-antibody reactions, physical trapping of particles, receptor site binding, removal of intentionally damaged cells from circulation, and transport of a chemical species across a cell membrane and into the cell by a normally operating metabolic process. There are many radiopharmaceutics for a large number of Nuclear medicine studies, each one enabling the visualization of a specific organ function/morphology in order to achieve a diagnosis and/or therapy. |
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Basics of drug transport & delivery and radiopharmacy for nuclear medical applicationsRadiopharmaceuticals are pharmaceutical substances which contain a radionuclide within their structure, not eliciting any physiological response. Radiopharmaceuticals can be used as imaging agents, function agents, in vitro studies and therapeutical agents. There are several criteria for radionuclide selection concerning in vivo applications: half-life, radiotoxicity, purity, specific activity, accessibility vs production cost. The design of radiopharmaceuticals is based upon physiological function of the target organ. The mechanism of localization of a radiopharmaceutical in a particular target organ depends on many processes: antigen-antibody reactions, physical trapping of particles, receptor site binding, removal of intentionally damaged cells from circulation, and transport of a chemical species across a cell membrane and into the cell by a normally operating metabolic process. There are many radiopharmaceutics for a large number of Nuclear medicine studies, each one enabling the visualization of a specific organ function/morphology in order to achieve a diagnosis and/or therapy.UA Editora2007-01-01T00:00:00Zconference objectconference objectinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://proa.ua.pt/index.php/revdeti/article/view/17130oai:proa.ua.pt:article/17130Eletrónica e Telecomunicações; Vol 4 No 7 (2007); 786-789Eletrónica e Telecomunicações; vol. 4 n.º 7 (2007); 786-7892182-97721645-0493reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://proa.ua.pt/index.php/revdeti/article/view/17130https://proa.ua.pt/index.php/revdeti/article/view/17130/12189https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessSantos, Cristina2022-09-26T11:00:10Zoai:proa.ua.pt:article/17130Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:08:07.345608Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
title |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
spellingShingle |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications Santos, Cristina |
title_short |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
title_full |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
title_fullStr |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
title_full_unstemmed |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
title_sort |
Basics of drug transport & delivery and radiopharmacy for nuclear medical applications |
author |
Santos, Cristina |
author_facet |
Santos, Cristina |
author_role |
author |
dc.contributor.author.fl_str_mv |
Santos, Cristina |
description |
Radiopharmaceuticals are pharmaceutical substances which contain a radionuclide within their structure, not eliciting any physiological response. Radiopharmaceuticals can be used as imaging agents, function agents, in vitro studies and therapeutical agents. There are several criteria for radionuclide selection concerning in vivo applications: half-life, radiotoxicity, purity, specific activity, accessibility vs production cost. The design of radiopharmaceuticals is based upon physiological function of the target organ. The mechanism of localization of a radiopharmaceutical in a particular target organ depends on many processes: antigen-antibody reactions, physical trapping of particles, receptor site binding, removal of intentionally damaged cells from circulation, and transport of a chemical species across a cell membrane and into the cell by a normally operating metabolic process. There are many radiopharmaceutics for a large number of Nuclear medicine studies, each one enabling the visualization of a specific organ function/morphology in order to achieve a diagnosis and/or therapy. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01T00:00:00Z |
dc.type.driver.fl_str_mv |
conference object conference object info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://proa.ua.pt/index.php/revdeti/article/view/17130 oai:proa.ua.pt:article/17130 |
url |
https://proa.ua.pt/index.php/revdeti/article/view/17130 |
identifier_str_mv |
oai:proa.ua.pt:article/17130 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://proa.ua.pt/index.php/revdeti/article/view/17130 https://proa.ua.pt/index.php/revdeti/article/view/17130/12189 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UA Editora |
publisher.none.fl_str_mv |
UA Editora |
dc.source.none.fl_str_mv |
Eletrónica e Telecomunicações; Vol 4 No 7 (2007); 786-789 Eletrónica e Telecomunicações; vol. 4 n.º 7 (2007); 786-789 2182-9772 1645-0493 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130539051974656 |