Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach

Detalhes bibliográficos
Autor(a) principal: Parreira, José Ricardo
Data de Publicação: 2020
Outros Autores: Hernández-Castellano, Lorenzo Henrique, Arguello, Anastasio, Capote, Juan, Castro, Noemi, Araújo, Susana de Sousa, Almeida, André Martinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/20390
Resumo: Research Article
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spelling Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approachgoatmammary glandtranscriptomicsRNA-sequencingseasonal weight lossResearch ArticleBackground: Seasonal weight loss (SWL) is a very important limitation to the production of ruminants in the Mediterranean and Tropical regions. In these areas, long dry seasons lead to poor pastures with low nutritional value. During the dry season, ruminants, particularly those raised in extensive production systems, lose around 30% of their body weight. Seasonal weight loss has important consequences on animal productive performance and health. In this study, RNA sequencing was used to characterize feed restriction effects in dairy goat of 2 breeds with different SWL tolerance: Majorera (tolerant) and Palmera (susceptible). Nine Majorera and ten Palmera goats were randomly distributed in a control and a restricted group: Majorera Control (adequately fed; MC; n = 4), Palmera Control (adequately fed; PC; n = 6), Majorera Restricted (feed restricted; ME; n = 5) and Palmera Restricted (feed restricted; PE; n = 4). On day 22 of the trial, mammary gland biopsies were collected for transcriptomics analysis. Results: From these samples, 24,260 unique transcripts were identified. From those, 82 transcripts were differentially expressed between MC and ME, 99 between PC and PE, twelve between both control groups and twenty-nine between both restricted groups. Conclusions: Feed restriction affected several biochemical pathways in both breeds such as: carbohydrate and lipid transport; intracellular trafficking, RNA processing and signal transduction. This research also highlights the importance or involvement of the genes in tolerance (ENPP1, S-LZ, MT2A and GPNB) and susceptibility (GPD1, CTPS1, ELOVL6 and NR4A1) to SWL with respectively higher expression in the Majorera restriced group and the Palmera restricted group in comparison to the control groups. In addition, results from the study may be extrapolated to other dairy ruminant speciesBMCRepositório da Universidade de LisboaParreira, José RicardoHernández-Castellano, Lorenzo HenriqueArguello, AnastasioCapote, JuanCastro, NoemiAraújo, Susana de SousaAlmeida, André Martinho2020-09-24T13:14:43Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/20390engParreira et al. BMC Genomics (2020) 21:629https://doi.org/10.1186/s12864-020-06968-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:49:49Zoai:www.repository.utl.pt:10400.5/20390Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:05:09.110053Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
title Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
spellingShingle Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
Parreira, José Ricardo
goat
mammary gland
transcriptomics
RNA-sequencing
seasonal weight loss
title_short Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
title_full Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
title_fullStr Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
title_full_unstemmed Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
title_sort Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach
author Parreira, José Ricardo
author_facet Parreira, José Ricardo
Hernández-Castellano, Lorenzo Henrique
Arguello, Anastasio
Capote, Juan
Castro, Noemi
Araújo, Susana de Sousa
Almeida, André Martinho
author_role author
author2 Hernández-Castellano, Lorenzo Henrique
Arguello, Anastasio
Capote, Juan
Castro, Noemi
Araújo, Susana de Sousa
Almeida, André Martinho
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Parreira, José Ricardo
Hernández-Castellano, Lorenzo Henrique
Arguello, Anastasio
Capote, Juan
Castro, Noemi
Araújo, Susana de Sousa
Almeida, André Martinho
dc.subject.por.fl_str_mv goat
mammary gland
transcriptomics
RNA-sequencing
seasonal weight loss
topic goat
mammary gland
transcriptomics
RNA-sequencing
seasonal weight loss
description Research Article
publishDate 2020
dc.date.none.fl_str_mv 2020-09-24T13:14:43Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/20390
url http://hdl.handle.net/10400.5/20390
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Parreira et al. BMC Genomics (2020) 21:629
https://doi.org/10.1186/s12864-020-06968-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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