Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review

Detalhes bibliográficos
Autor(a) principal: Silva, Inês
Data de Publicação: 2021
Outros Autores: Alípio, Carolina, Pinto, Rui, Mateus, Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/13309
Resumo: Projeto IPL/2020/cEPO_ESTeSL
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spelling Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic reviewErythropoietinInflammationNon-clinical studies in vivoAnimal modelRodentsProjeto IPL/2020/cEPO_ESTeSLProjeto IPL/2020/cEPO_ESTeSLErythropoietin (EPO) is a hypoxia-induced hormone produced in adult kidneys with erythropoietic and non-erythropoietic effects. In vivo studies represent an important role to comprehend the efficacy and safety in the early phase of repurposing drugs. The aim is to evaluate the potential anti-inflammatory effect of EPO observed in animal models of disease. Following PRISMA statements, electronic database Medline via PubMed platform was used to search articles with the research expression ((erythropoietin [MeSH Terms]) AND (inflammation [MeSH Terms]) AND (disease models, animal [MeSH Terms])). The inclusion criteria were original articles, studies where EPO was administered, studies where inflammation was studied and/or evaluated, non-clinical studies in vivo with rodents, and articles published in English. Thirty-six articles met the criteria for qualitative analysis. Exogenous EPO was used in models of sepsis, traumatic brain injury, and autoimmune neuritis, with an average of 3000 IU/Kg for single and multiple doses, using mice and rats. Biomarkers such as immune-related effectors, cytokines, reactive oxygen species, prostaglandins, and other biomarkers were assessed. EPO has been recognized as a multifunctional cytokine with anti-inflammatory properties, showing its significant effect both in acute and chronic models of inflammation. Further non-clinical studies are suggested for the enlightenment of anti-inflammatory mechanisms of EPO in lower doses, allowing us to understand the translational data for humans.ElsevierRCIPLSilva, InêsAlípio, CarolinaPinto, RuiMateus, Vanessa2021-05-07T15:20:35Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13309engSilva I, Alípio C, Pinto R, Mateus V. Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review. Biomed Pharmacother. 2021;139:111558.10.1016/j.biopha.2021.111558info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:07:49Zoai:repositorio.ipl.pt:10400.21/13309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:17.191262Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
title Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
spellingShingle Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
Silva, Inês
Erythropoietin
Inflammation
Non-clinical studies in vivo
Animal model
Rodents
Projeto IPL/2020/cEPO_ESTeSL
title_short Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
title_full Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
title_fullStr Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
title_full_unstemmed Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
title_sort Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review
author Silva, Inês
author_facet Silva, Inês
Alípio, Carolina
Pinto, Rui
Mateus, Vanessa
author_role author
author2 Alípio, Carolina
Pinto, Rui
Mateus, Vanessa
author2_role author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Silva, Inês
Alípio, Carolina
Pinto, Rui
Mateus, Vanessa
dc.subject.por.fl_str_mv Erythropoietin
Inflammation
Non-clinical studies in vivo
Animal model
Rodents
Projeto IPL/2020/cEPO_ESTeSL
topic Erythropoietin
Inflammation
Non-clinical studies in vivo
Animal model
Rodents
Projeto IPL/2020/cEPO_ESTeSL
description Projeto IPL/2020/cEPO_ESTeSL
publishDate 2021
dc.date.none.fl_str_mv 2021-05-07T15:20:35Z
2021-07
2021-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/13309
url http://hdl.handle.net/10400.21/13309
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva I, Alípio C, Pinto R, Mateus V. Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review. Biomed Pharmacother. 2021;139:111558.
10.1016/j.biopha.2021.111558
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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