Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function

Detalhes bibliográficos
Autor(a) principal: Brito, C
Data de Publicação: 2020
Outros Autores: Sousa, S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/143490
Resumo: Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskeleton, required for proper cell division, adhesion and migration, among other cellular functions. Although NM2A has been extensively studied, new findings revealed that a lot remains to be discovered concerning its spatiotemporal regulation in the intracellular environment. In recent years, new functions were attributed to NM2A and its activity was associated to a plethora of illnesses, including neurological disorders and infectious diseases. Here, we provide a concise overview on the current knowledge regarding the structure, the function and the regulation of NM2A. In addition, we recapitulate NM2A-associated diseases and discuss its potential as a therapeutic target.
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spelling Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Functionactomyosin cytoskeletoncell adhesioncell migrationNM2A activity regulationNM2A filament assemblynon-muscle myosin 2A (NM2A)plasma membrane blebbingNon-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskeleton, required for proper cell division, adhesion and migration, among other cellular functions. Although NM2A has been extensively studied, new findings revealed that a lot remains to be discovered concerning its spatiotemporal regulation in the intracellular environment. In recent years, new functions were attributed to NM2A and its activity was associated to a plethora of illnesses, including neurological disorders and infectious diseases. Here, we provide a concise overview on the current knowledge regarding the structure, the function and the regulation of NM2A. In addition, we recapitulate NM2A-associated diseases and discuss its potential as a therapeutic target.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143490eng2073-440910.3390/cells9071590Brito, CSousa, Sinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:44:05Zoai:repositorio-aberto.up.pt:10216/143490Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:25:40.044286Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
title Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
spellingShingle Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
Brito, C
actomyosin cytoskeleton
cell adhesion
cell migration
NM2A activity regulation
NM2A filament assembly
non-muscle myosin 2A (NM2A)
plasma membrane blebbing
title_short Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
title_full Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
title_fullStr Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
title_full_unstemmed Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
title_sort Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
author Brito, C
author_facet Brito, C
Sousa, S
author_role author
author2 Sousa, S
author2_role author
dc.contributor.author.fl_str_mv Brito, C
Sousa, S
dc.subject.por.fl_str_mv actomyosin cytoskeleton
cell adhesion
cell migration
NM2A activity regulation
NM2A filament assembly
non-muscle myosin 2A (NM2A)
plasma membrane blebbing
topic actomyosin cytoskeleton
cell adhesion
cell migration
NM2A activity regulation
NM2A filament assembly
non-muscle myosin 2A (NM2A)
plasma membrane blebbing
description Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskeleton, required for proper cell division, adhesion and migration, among other cellular functions. Although NM2A has been extensively studied, new findings revealed that a lot remains to be discovered concerning its spatiotemporal regulation in the intracellular environment. In recent years, new functions were attributed to NM2A and its activity was associated to a plethora of illnesses, including neurological disorders and infectious diseases. Here, we provide a concise overview on the current knowledge regarding the structure, the function and the regulation of NM2A. In addition, we recapitulate NM2A-associated diseases and discuss its potential as a therapeutic target.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/143490
url https://hdl.handle.net/10216/143490
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
10.3390/cells9071590
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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