Fusion proteins towards fungi and bacteria in plant protection

Detalhes bibliográficos
Autor(a) principal: Pinheiro, Ana Margarida
Data de Publicação: 2018
Outros Autores: Carreira, Alexandra, Ferreira, Ricardo B., Monteiro, Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/14875
Resumo: Research Article
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spelling Fusion proteins towards fungi and bacteria in plant protectionfungibacteriafusion proteinsplant protectionResearch ArticleIn agriculture, although fungi are considered the foremost problem, infections by bacteria also cause significant economical losses. The presence of different diseases in crops often leads to a misuse of the proper therapeutic, or the combination of different diseases forces the use of more than one pesticide. This work concerns the development of a ‘super-Blad’: a chimeric protein consisting of Blad polypeptide, the active ingredient of a biological fungicide already on the market, and two selected peptides, SP10-5 and Sub5, proven to possess biological potential as antibacterial agents. The resulting chimeric protein obtained from the fusion of Blad with SP10-5 not only maintained strong antibacterial activity, especially against Xanthomonas spp. and Pseudomonas syringae, but was also able to retain the ability to inhibit the growth of both yeast and filamentous fungi. However, the antibacterial activity of Sub5 was considerably diminished when fused with Blad, which seems to indicate that not all fusion proteins behave equally. These newly designed drugs can be considered promising compounds for use in plant protection. A deeper and focused development of an appropriate formulation may result in a potent biopesticide that can replace, per se, two conventional chemistries with less impact on the environmentMicrobiology SocietyRepositório da Universidade de LisboaPinheiro, Ana MargaridaCarreira, AlexandraFerreira, Ricardo B.Monteiro, Sara2018-02-05T15:12:47Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/14875engPinheiro et al., Microbiology 2018;164:11–1910.1099/mic.0.000592info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:44:53Zoai:www.repository.utl.pt:10400.5/14875Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:00:39.499580Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fusion proteins towards fungi and bacteria in plant protection
title Fusion proteins towards fungi and bacteria in plant protection
spellingShingle Fusion proteins towards fungi and bacteria in plant protection
Pinheiro, Ana Margarida
fungi
bacteria
fusion proteins
plant protection
title_short Fusion proteins towards fungi and bacteria in plant protection
title_full Fusion proteins towards fungi and bacteria in plant protection
title_fullStr Fusion proteins towards fungi and bacteria in plant protection
title_full_unstemmed Fusion proteins towards fungi and bacteria in plant protection
title_sort Fusion proteins towards fungi and bacteria in plant protection
author Pinheiro, Ana Margarida
author_facet Pinheiro, Ana Margarida
Carreira, Alexandra
Ferreira, Ricardo B.
Monteiro, Sara
author_role author
author2 Carreira, Alexandra
Ferreira, Ricardo B.
Monteiro, Sara
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pinheiro, Ana Margarida
Carreira, Alexandra
Ferreira, Ricardo B.
Monteiro, Sara
dc.subject.por.fl_str_mv fungi
bacteria
fusion proteins
plant protection
topic fungi
bacteria
fusion proteins
plant protection
description Research Article
publishDate 2018
dc.date.none.fl_str_mv 2018-02-05T15:12:47Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/14875
url http://hdl.handle.net/10400.5/14875
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pinheiro et al., Microbiology 2018;164:11–19
10.1099/mic.0.000592
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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