Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/27171 |
Resumo: | Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products. |
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Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidolAntimicrobialPolymerToxicityChicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.MDPIBiblioteca Digital do IPBLima, Idglan SáFerreira, Maria Onaira GonçalvesBarros, Esmeralda Maria LustosaRizzo, Marcia SantosSantos, Jailson de AraujoRibeiro, Alessandra BragaFurtini, Josy Anteveli OsajimaSilva-Filho, Edson C.Estevinho, Leticia M.2023-02-24T11:27:35Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/27171engLima, Idglan Sá; Ferreira, Maria Onaira Gonçalves; Barros, Esmeralda Maria Lustosa; Rizzo, Marcia Santos; Santos, Jailson de Araujo; Ribeiro, Alessandra Braga; Furtini, Josy Anteveli Osajima; Silva-Filho, Edson C.; Estevinho, Leticia M.. (2023). Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol. International Journal of Molecular Sciences. eISSN 1422-0067. 24:3, p. 1-2010.3390/ijms240322101422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T01:18:47Zoai:bibliotecadigital.ipb.pt:10198/27171Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:17:33.461864Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
title |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
spellingShingle |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol Lima, Idglan Sá Antimicrobial Polymer Toxicity |
title_short |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
title_full |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
title_fullStr |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
title_full_unstemmed |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
title_sort |
Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol |
author |
Lima, Idglan Sá |
author_facet |
Lima, Idglan Sá Ferreira, Maria Onaira Gonçalves Barros, Esmeralda Maria Lustosa Rizzo, Marcia Santos Santos, Jailson de Araujo Ribeiro, Alessandra Braga Furtini, Josy Anteveli Osajima Silva-Filho, Edson C. Estevinho, Leticia M. |
author_role |
author |
author2 |
Ferreira, Maria Onaira Gonçalves Barros, Esmeralda Maria Lustosa Rizzo, Marcia Santos Santos, Jailson de Araujo Ribeiro, Alessandra Braga Furtini, Josy Anteveli Osajima Silva-Filho, Edson C. Estevinho, Leticia M. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Lima, Idglan Sá Ferreira, Maria Onaira Gonçalves Barros, Esmeralda Maria Lustosa Rizzo, Marcia Santos Santos, Jailson de Araujo Ribeiro, Alessandra Braga Furtini, Josy Anteveli Osajima Silva-Filho, Edson C. Estevinho, Leticia M. |
dc.subject.por.fl_str_mv |
Antimicrobial Polymer Toxicity |
topic |
Antimicrobial Polymer Toxicity |
description |
Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-24T11:27:35Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/27171 |
url |
http://hdl.handle.net/10198/27171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lima, Idglan Sá; Ferreira, Maria Onaira Gonçalves; Barros, Esmeralda Maria Lustosa; Rizzo, Marcia Santos; Santos, Jailson de Araujo; Ribeiro, Alessandra Braga; Furtini, Josy Anteveli Osajima; Silva-Filho, Edson C.; Estevinho, Leticia M.. (2023). Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol. International Journal of Molecular Sciences. eISSN 1422-0067. 24:3, p. 1-20 10.3390/ijms24032210 1422-0067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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MDPI |
publisher.none.fl_str_mv |
MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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