Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol

Detalhes bibliográficos
Autor(a) principal: Lima, Idglan Sá
Data de Publicação: 2023
Outros Autores: Ferreira, Maria Onaira Gonçalves, Barros, Esmeralda Maria Lustosa, Rizzo, Marcia Santos, Santos, Jailson de Araujo, Ribeiro, Alessandra Braga, Furtini, Josy Anteveli Osajima, Silva-Filho, Edson C., Estevinho, Leticia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/27171
Resumo: Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.
id RCAP_7e3f93445c6b88c82b779d7a198123ee
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/27171
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidolAntimicrobialPolymerToxicityChicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.MDPIBiblioteca Digital do IPBLima, Idglan SáFerreira, Maria Onaira GonçalvesBarros, Esmeralda Maria LustosaRizzo, Marcia SantosSantos, Jailson de AraujoRibeiro, Alessandra BragaFurtini, Josy Anteveli OsajimaSilva-Filho, Edson C.Estevinho, Leticia M.2023-02-24T11:27:35Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/27171engLima, Idglan Sá; Ferreira, Maria Onaira Gonçalves; Barros, Esmeralda Maria Lustosa; Rizzo, Marcia Santos; Santos, Jailson de Araujo; Ribeiro, Alessandra Braga; Furtini, Josy Anteveli Osajima; Silva-Filho, Edson C.; Estevinho, Leticia M.. (2023). Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol. International Journal of Molecular Sciences. eISSN 1422-0067. 24:3, p. 1-2010.3390/ijms240322101422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T01:18:47Zoai:bibliotecadigital.ipb.pt:10198/27171Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:17:33.461864Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
title Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
spellingShingle Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
Lima, Idglan Sá
Antimicrobial
Polymer
Toxicity
title_short Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
title_full Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
title_fullStr Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
title_full_unstemmed Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
title_sort Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol
author Lima, Idglan Sá
author_facet Lima, Idglan Sá
Ferreira, Maria Onaira Gonçalves
Barros, Esmeralda Maria Lustosa
Rizzo, Marcia Santos
Santos, Jailson de Araujo
Ribeiro, Alessandra Braga
Furtini, Josy Anteveli Osajima
Silva-Filho, Edson C.
Estevinho, Leticia M.
author_role author
author2 Ferreira, Maria Onaira Gonçalves
Barros, Esmeralda Maria Lustosa
Rizzo, Marcia Santos
Santos, Jailson de Araujo
Ribeiro, Alessandra Braga
Furtini, Josy Anteveli Osajima
Silva-Filho, Edson C.
Estevinho, Leticia M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Lima, Idglan Sá
Ferreira, Maria Onaira Gonçalves
Barros, Esmeralda Maria Lustosa
Rizzo, Marcia Santos
Santos, Jailson de Araujo
Ribeiro, Alessandra Braga
Furtini, Josy Anteveli Osajima
Silva-Filho, Edson C.
Estevinho, Leticia M.
dc.subject.por.fl_str_mv Antimicrobial
Polymer
Toxicity
topic Antimicrobial
Polymer
Toxicity
description Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL(-1). Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100-3550 cm(-1). The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL(-1) nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.
publishDate 2023
dc.date.none.fl_str_mv 2023-02-24T11:27:35Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/27171
url http://hdl.handle.net/10198/27171
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lima, Idglan Sá; Ferreira, Maria Onaira Gonçalves; Barros, Esmeralda Maria Lustosa; Rizzo, Marcia Santos; Santos, Jailson de Araujo; Ribeiro, Alessandra Braga; Furtini, Josy Anteveli Osajima; Silva-Filho, Edson C.; Estevinho, Leticia M.. (2023). Antibacterial and healing effect of chicha gum hydrogel (Sterculia striata) with nerolidol. International Journal of Molecular Sciences. eISSN 1422-0067. 24:3, p. 1-20
10.3390/ijms24032210
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135466153312256