Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release

Detalhes bibliográficos
Autor(a) principal: Salgado, M.
Data de Publicação: 2017
Outros Autores: Rodríguez-Royo, S., Reis, R. L., Cocero, M. J., Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/46883
Resumo: Porous polymeric materials are studied in tissue engineering, because they can act as support for cell proliferation and as drug delivery vehicles for regeneration of tissues. Hydrogel foaming with supercritical CO2 is a suitable alternative for the creation of these structures, since it avoids the use of organic solvents and high temperature in the processing. In this work, β-glucans were used as raw materials to create hydrogels due to their easily gelation and biological properties. The enhancement of porosity was generated by a fast decompression after keeping the hydrogels in contact with CO2. The effect of the processing conditions and type of β-glucan in the final properties was assessed regarding morphological and mechanical properties. Finally, the ability of these materials to sustainably deliver dexamethasone was evaluated. The scaffolds had good morphology and provided a controlled release, thus being suitable to be used as scaffolds and drug delivery vehicles.
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spelling Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone releaseDexamethasoneDrug deliveryScaffoldsSupercritical hydrogel foamingβ-Glucanbeta-GlucanScience & TechnologyPorous polymeric materials are studied in tissue engineering, because they can act as support for cell proliferation and as drug delivery vehicles for regeneration of tissues. Hydrogel foaming with supercritical CO2 is a suitable alternative for the creation of these structures, since it avoids the use of organic solvents and high temperature in the processing. In this work, β-glucans were used as raw materials to create hydrogels due to their easily gelation and biological properties. The enhancement of porosity was generated by a fast decompression after keeping the hydrogels in contact with CO2. The effect of the processing conditions and type of β-glucan in the final properties was assessed regarding morphological and mechanical properties. Finally, the ability of these materials to sustainably deliver dexamethasone was evaluated. The scaffolds had good morphology and provided a controlled release, thus being suitable to be used as scaffolds and drug delivery vehicles.Authors acknowledge Ministerio de Economía y Competitividad (MINECO) through project CTQ2013-44143-R and project PIP 063/ 147181 from Fundación General of the University of Valladolid for financial support. M. Salgado thanks to Ministerio de Educación, Ciencia y Deporte (MECD) for her FPU and mobility grants. S. Rodríguez-Rojo acknowledges to MINECO and UVa for her Juan de la Cierva fellowship (JCI-2012-14992). The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number REGPOT-CT2012-316331-POLARIS and from the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1 − ABMR − NORTE-01-0124-FEDER-000016) co- financed by North Portugal Regional Operational Programme (ON.2–O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).info:eu-repo/semantics/publishedVersionElsevier B.V.Universidade do MinhoSalgado, M.Rodríguez-Royo, S.Reis, R. L.Cocero, M. J.Duarte, Ana Rita C.2017-052017-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/46883engSalgado M., Rodríguez-Rojo S., Reis R. L., Cocero M. J., Duarte A. R. C. Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: Evaluation of dexamethasone release, The Journal of Supercritical fluids, Vol. 127, pp. 158-165, doi:10.1016/j.supflu.2017.04.006, 20170896-84461872-816210.1016/j.supflu.2017.04.006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:40:36Zoai:repositorium.sdum.uminho.pt:1822/46883Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:37:27.122032Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
title Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
spellingShingle Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
Salgado, M.
Dexamethasone
Drug delivery
Scaffolds
Supercritical hydrogel foaming
β-Glucan
beta-Glucan
Science & Technology
title_short Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
title_full Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
title_fullStr Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
title_full_unstemmed Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
title_sort Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: evaluation of dexamethasone release
author Salgado, M.
author_facet Salgado, M.
Rodríguez-Royo, S.
Reis, R. L.
Cocero, M. J.
Duarte, Ana Rita C.
author_role author
author2 Rodríguez-Royo, S.
Reis, R. L.
Cocero, M. J.
Duarte, Ana Rita C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Salgado, M.
Rodríguez-Royo, S.
Reis, R. L.
Cocero, M. J.
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Dexamethasone
Drug delivery
Scaffolds
Supercritical hydrogel foaming
β-Glucan
beta-Glucan
Science & Technology
topic Dexamethasone
Drug delivery
Scaffolds
Supercritical hydrogel foaming
β-Glucan
beta-Glucan
Science & Technology
description Porous polymeric materials are studied in tissue engineering, because they can act as support for cell proliferation and as drug delivery vehicles for regeneration of tissues. Hydrogel foaming with supercritical CO2 is a suitable alternative for the creation of these structures, since it avoids the use of organic solvents and high temperature in the processing. In this work, β-glucans were used as raw materials to create hydrogels due to their easily gelation and biological properties. The enhancement of porosity was generated by a fast decompression after keeping the hydrogels in contact with CO2. The effect of the processing conditions and type of β-glucan in the final properties was assessed regarding morphological and mechanical properties. Finally, the ability of these materials to sustainably deliver dexamethasone was evaluated. The scaffolds had good morphology and provided a controlled release, thus being suitable to be used as scaffolds and drug delivery vehicles.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
2017-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/46883
url http://hdl.handle.net/1822/46883
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Salgado M., Rodríguez-Rojo S., Reis R. L., Cocero M. J., Duarte A. R. C. Preparation of barley and yeast β-glucan scaffolds by hydrogel foaming: Evaluation of dexamethasone release, The Journal of Supercritical fluids, Vol. 127, pp. 158-165, doi:10.1016/j.supflu.2017.04.006, 2017
0896-8446
1872-8162
10.1016/j.supflu.2017.04.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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