Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality

Detalhes bibliográficos
Autor(a) principal: Bernardo, Sónia
Data de Publicação: 2021
Outros Autores: Crespo, Ricardo Rios, Saraiva, Sofia, Barata, Rui, Gonçalves, Sara, Nogueira, Paulo Jorge, Cortez-Pinto, Helena, Machado, Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56676
Resumo: Copyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortalityCopyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Most long-term heavy drinkers do not have clinically evident chronic liver disease (CLD). However, at any time-point, their risk of developing CLD remains unknown. We aimed to evaluate the long-term outcomes of a group of heavy drinkers, without evidence of CLD at baseline. Methods: A cohort of 123 long-term heavy drinkers without CLD were prospectively recruited in 2002 and retrospectively followed until 2018. Results: At baseline (2002), median alcohol consumption was 271±203g/day during 21.5±20 years, 65% being abstinent during the previous 1.75±5 months. Patients were followed for 14±3 years. During follow-up, 53% reported any alcohol intake. Alcohol consumption during follow-up associated weakly with either 1- or 6-months previous abstinence at baseline. Until 2018, progression to CLD occurred in 6%, associating with years of alcohol intake during follow-up (OR 1.15 [1.01-1.31]) and baseline alkaline-phosphatase (OR 1.05 [1.01-1.10]). During follow-up, being abstinent for at least 1 year positively associated with CLD-free survival. 27% died (55% of cancer-mostly oropharyngeal cancer, 27% of cardiovascular disease, and 9% of liver disease), with a mean age of 71 years [69-74] (10 years less than the expected in the Portuguese population). Achieving abstinence for at least 1 year positively associated with overall survival, while smoking, and hepatic steatosis at baseline associated negatively. Conclusion: Long-term heavy drinkers seemed to have a decreased life expectancy compared with the overall Portuguese population. Cancer was the main cause of death. Our results suggest that progression to CLD depends mostly on continued alcohol intake. Alcohol abstinence, even if temporary, seems to decrease the risks of CLD and mortality.PLOSRepositório da Universidade de LisboaBernardo, SóniaCrespo, Ricardo RiosSaraiva, SofiaBarata, RuiGonçalves, SaraNogueira, Paulo JorgeCortez-Pinto, HelenaMachado, Mariana2023-03-15T15:59:17Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56676engPLoS One. 2021 May 25;16(5):e025221810.1371/journal.pone.02522181932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:31Zoai:repositorio.ul.pt:10451/56676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:13.714693Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
title Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
spellingShingle Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
Bernardo, Sónia
title_short Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
title_full Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
title_fullStr Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
title_full_unstemmed Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
title_sort Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
author Bernardo, Sónia
author_facet Bernardo, Sónia
Crespo, Ricardo Rios
Saraiva, Sofia
Barata, Rui
Gonçalves, Sara
Nogueira, Paulo Jorge
Cortez-Pinto, Helena
Machado, Mariana
author_role author
author2 Crespo, Ricardo Rios
Saraiva, Sofia
Barata, Rui
Gonçalves, Sara
Nogueira, Paulo Jorge
Cortez-Pinto, Helena
Machado, Mariana
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bernardo, Sónia
Crespo, Ricardo Rios
Saraiva, Sofia
Barata, Rui
Gonçalves, Sara
Nogueira, Paulo Jorge
Cortez-Pinto, Helena
Machado, Mariana
description Copyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2023-03-15T15:59:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56676
url http://hdl.handle.net/10451/56676
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2021 May 25;16(5):e0252218
10.1371/journal.pone.0252218
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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