Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/56676 |
Resumo: | Copyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortalityCopyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Most long-term heavy drinkers do not have clinically evident chronic liver disease (CLD). However, at any time-point, their risk of developing CLD remains unknown. We aimed to evaluate the long-term outcomes of a group of heavy drinkers, without evidence of CLD at baseline. Methods: A cohort of 123 long-term heavy drinkers without CLD were prospectively recruited in 2002 and retrospectively followed until 2018. Results: At baseline (2002), median alcohol consumption was 271±203g/day during 21.5±20 years, 65% being abstinent during the previous 1.75±5 months. Patients were followed for 14±3 years. During follow-up, 53% reported any alcohol intake. Alcohol consumption during follow-up associated weakly with either 1- or 6-months previous abstinence at baseline. Until 2018, progression to CLD occurred in 6%, associating with years of alcohol intake during follow-up (OR 1.15 [1.01-1.31]) and baseline alkaline-phosphatase (OR 1.05 [1.01-1.10]). During follow-up, being abstinent for at least 1 year positively associated with CLD-free survival. 27% died (55% of cancer-mostly oropharyngeal cancer, 27% of cardiovascular disease, and 9% of liver disease), with a mean age of 71 years [69-74] (10 years less than the expected in the Portuguese population). Achieving abstinence for at least 1 year positively associated with overall survival, while smoking, and hepatic steatosis at baseline associated negatively. Conclusion: Long-term heavy drinkers seemed to have a decreased life expectancy compared with the overall Portuguese population. Cancer was the main cause of death. Our results suggest that progression to CLD depends mostly on continued alcohol intake. Alcohol abstinence, even if temporary, seems to decrease the risks of CLD and mortality.PLOSRepositório da Universidade de LisboaBernardo, SóniaCrespo, Ricardo RiosSaraiva, SofiaBarata, RuiGonçalves, SaraNogueira, Paulo JorgeCortez-Pinto, HelenaMachado, Mariana2023-03-15T15:59:17Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56676engPLoS One. 2021 May 25;16(5):e025221810.1371/journal.pone.02522181932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:31Zoai:repositorio.ul.pt:10451/56676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:13.714693Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
title |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
spellingShingle |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality Bernardo, Sónia |
title_short |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
title_full |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
title_fullStr |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
title_full_unstemmed |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
title_sort |
Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: heavy burden of cancer and liver disease mortality |
author |
Bernardo, Sónia |
author_facet |
Bernardo, Sónia Crespo, Ricardo Rios Saraiva, Sofia Barata, Rui Gonçalves, Sara Nogueira, Paulo Jorge Cortez-Pinto, Helena Machado, Mariana |
author_role |
author |
author2 |
Crespo, Ricardo Rios Saraiva, Sofia Barata, Rui Gonçalves, Sara Nogueira, Paulo Jorge Cortez-Pinto, Helena Machado, Mariana |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bernardo, Sónia Crespo, Ricardo Rios Saraiva, Sofia Barata, Rui Gonçalves, Sara Nogueira, Paulo Jorge Cortez-Pinto, Helena Machado, Mariana |
description |
Copyright: © 2021 Bernardo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-03-15T15:59:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/56676 |
url |
http://hdl.handle.net/10451/56676 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS One. 2021 May 25;16(5):e0252218 10.1371/journal.pone.0252218 1932-6203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PLOS |
publisher.none.fl_str_mv |
PLOS |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134625514127360 |