Otitis media pathogens A life entrapped in biofilm communities

Detalhes bibliográficos
Autor(a) principal: Silva, Maria Daniela
Data de Publicação: 2019
Outros Autores: Sillankorva, Sanna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/63351
Resumo: Otitis media is a group of inflammatory diseases of the middle ear with great impact on children worldwide. The most common reported bacterial pathogens are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Over the last years, the role of biofilms formed by otopathogens that contribute to otitis media recurrence and chronicity has been established. An improved understanding of the properties of biofilms formed by these bacteria, which factors influence them, and how these affect the host inflammatory response is important for the development of novel strategies for the treatment of otitis media. This review focuses on the biofilm nature that the most prevalent otopathogens adopt in otitis media infections. In addition, new treatment approaches targeting biofilms are highlighted.
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spelling Otitis media pathogens A life entrapped in biofilm communitiesotitis mediabiofilmsStreptococcus pneumoniaeHaemophilus influenzaeMoraxella catarrhalisScience & TechnologyOtitis media is a group of inflammatory diseases of the middle ear with great impact on children worldwide. The most common reported bacterial pathogens are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Over the last years, the role of biofilms formed by otopathogens that contribute to otitis media recurrence and chronicity has been established. An improved understanding of the properties of biofilms formed by these bacteria, which factors influence them, and how these affect the host inflammatory response is important for the development of novel strategies for the treatment of otitis media. This review focuses on the biofilm nature that the most prevalent otopathogens adopt in otitis media infections. In addition, new treatment approaches targeting biofilms are highlighted.MDS acknowledges the Portuguese Foundation for Scienceand Technology (FCT) grant [SFRH/BD/128825/2017]. Thisstudy was supported by the Portuguese Foundation forScience and Technology (FCT) under the scope of the strategic funding of [UID/BIO/04469/2019] unit and BioTecNorteoperation [NORTE-01–0145-FEDER-000004] funded by theEuropean Regional Development Fund under the scope ofNorte2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersionTaylor and FrancisUniversidade do MinhoSilva, Maria DanielaSillankorva, Sanna2019-09-102019-09-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63351engSilva, Maria Daniela; Sillankorva, Sanna, Otitis media pathogens A life entrapped in biofilm communities. Critical Reviews in Microbiology, 45(5-6), 595-612, 20191040-841X1549-782810.1080/1040841X.2019.166061631502909http://informahealthcare.com/journal/mbyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:12Zoai:repositorium.sdum.uminho.pt:1822/63351Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:24.074668Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Otitis media pathogens A life entrapped in biofilm communities
title Otitis media pathogens A life entrapped in biofilm communities
spellingShingle Otitis media pathogens A life entrapped in biofilm communities
Silva, Maria Daniela
otitis media
biofilms
Streptococcus pneumoniae
Haemophilus influenzae
Moraxella catarrhalis
Science & Technology
title_short Otitis media pathogens A life entrapped in biofilm communities
title_full Otitis media pathogens A life entrapped in biofilm communities
title_fullStr Otitis media pathogens A life entrapped in biofilm communities
title_full_unstemmed Otitis media pathogens A life entrapped in biofilm communities
title_sort Otitis media pathogens A life entrapped in biofilm communities
author Silva, Maria Daniela
author_facet Silva, Maria Daniela
Sillankorva, Sanna
author_role author
author2 Sillankorva, Sanna
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Maria Daniela
Sillankorva, Sanna
dc.subject.por.fl_str_mv otitis media
biofilms
Streptococcus pneumoniae
Haemophilus influenzae
Moraxella catarrhalis
Science & Technology
topic otitis media
biofilms
Streptococcus pneumoniae
Haemophilus influenzae
Moraxella catarrhalis
Science & Technology
description Otitis media is a group of inflammatory diseases of the middle ear with great impact on children worldwide. The most common reported bacterial pathogens are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Over the last years, the role of biofilms formed by otopathogens that contribute to otitis media recurrence and chronicity has been established. An improved understanding of the properties of biofilms formed by these bacteria, which factors influence them, and how these affect the host inflammatory response is important for the development of novel strategies for the treatment of otitis media. This review focuses on the biofilm nature that the most prevalent otopathogens adopt in otitis media infections. In addition, new treatment approaches targeting biofilms are highlighted.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-10
2019-09-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63351
url http://hdl.handle.net/1822/63351
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, Maria Daniela; Sillankorva, Sanna, Otitis media pathogens A life entrapped in biofilm communities. Critical Reviews in Microbiology, 45(5-6), 595-612, 2019
1040-841X
1549-7828
10.1080/1040841X.2019.1660616
31502909
http://informahealthcare.com/journal/mby
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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