Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey

Detalhes bibliográficos
Autor(a) principal: Marques, José Gonçalo
Data de Publicação: 2023
Outros Autores: Inácio Cunha, Florbela Maria, Bajanca-Lavado, Maria Paula, Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/9034
Resumo: Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children: Celia Bettencourt, Arminda Maria Jorge, Maria Conceição Faria, Carla Zilhão, Laura Marques, Conceição Casanova, Cristiana Pereira, Fernando Fonseca, Cláudia Monteiro, Mariana Bettencourt, Diana Moreira, Fernanda Rodrigues, Henrique Oliveira, Catarina Sousa, Graciete Pinheiro, Sara Diogo Santos, Adília Vicente, Tiago Milheiro, Margarida Pinto, Graça Seves, Rosa Bento, M ª João Virtuoso, Rita Fonseca, Maria Dinah Carvalho, Luís Lito, Carla Cruz, Adriana Coutinho, Paula Correia, Luísa Sancho, Elzara Aliyeva, Cristina Freitas, Nuno Canhoto, Ana Filipa Nunes, Ana Maria Queiroz, José Diogo, Maria Manuel Flores, Paula Reis, Elmano Ramalheira, Maria Manuel Zarcos, Sofia Lima, Susana Castilho, Catarina Lacerda, Luísa Teixeira, Ana Maria Jesus, Sofia Maia Aroso, Margarida Tavares, Bonito Vitor, Angélica Ramos, Manuela Costa Alves, Isabel Cunha, Alberta Faustino, Álvaro Sousa, Margarida Rodrigues, Idalina Maciel, Sandra Vieira, Jorge Rodrigues, Elisabete Santos, Alexandra Costa, Filomena Martins, Carlos Escobar, Pedro Flores, Maria Favila Menezes, João Calado Nunes, Ana Neto, Marina Soares, Rita Mouro Pinto, Diana Almeida, Isabel Brito, Hermínia Costa, Fátima Silva, Joana Cardoso, Magalys Pereira, Luís Gonçalves, João Tavares, Sofia Botelho Moniz, Eurico Jorge Gaspar, Joana Carvalho, Ana Paula Castro, Álvaro Sousa, Catarina Francisco, João Farela Neves, Paulo Paixão
id RCAP_7fda1558d3c41b33de61d1c7a24757d2
oai_identifier_str oai:repositorio.insa.pt:10400.18/9034
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric SurveyHaemophilus influenzaeSerotypeHibVaccine FailurePaediatric InfectionsInvasive DiseaseInfecções RespiratóriasPortugalPortuguese Study Group on Haemophilus influenzae Invasive Disease in Children: Celia Bettencourt, Arminda Maria Jorge, Maria Conceição Faria, Carla Zilhão, Laura Marques, Conceição Casanova, Cristiana Pereira, Fernando Fonseca, Cláudia Monteiro, Mariana Bettencourt, Diana Moreira, Fernanda Rodrigues, Henrique Oliveira, Catarina Sousa, Graciete Pinheiro, Sara Diogo Santos, Adília Vicente, Tiago Milheiro, Margarida Pinto, Graça Seves, Rosa Bento, M ª João Virtuoso, Rita Fonseca, Maria Dinah Carvalho, Luís Lito, Carla Cruz, Adriana Coutinho, Paula Correia, Luísa Sancho, Elzara Aliyeva, Cristina Freitas, Nuno Canhoto, Ana Filipa Nunes, Ana Maria Queiroz, José Diogo, Maria Manuel Flores, Paula Reis, Elmano Ramalheira, Maria Manuel Zarcos, Sofia Lima, Susana Castilho, Catarina Lacerda, Luísa Teixeira, Ana Maria Jesus, Sofia Maia Aroso, Margarida Tavares, Bonito Vitor, Angélica Ramos, Manuela Costa Alves, Isabel Cunha, Alberta Faustino, Álvaro Sousa, Margarida Rodrigues, Idalina Maciel, Sandra Vieira, Jorge Rodrigues, Elisabete Santos, Alexandra Costa, Filomena Martins, Carlos Escobar, Pedro Flores, Maria Favila Menezes, João Calado Nunes, Ana Neto, Marina Soares, Rita Mouro Pinto, Diana Almeida, Isabel Brito, Hermínia Costa, Fátima Silva, Joana Cardoso, Magalys Pereira, Luís Gonçalves, João Tavares, Sofia Botelho Moniz, Eurico Jorge Gaspar, Joana Carvalho, Ana Paula Castro, Álvaro Sousa, Catarina Francisco, João Farela Neves, Paulo PaixãoMulticenter StudyAbstract: Background: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised ( P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases ( P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented.Lippincott, Williams & WilkinsRepositório Científico do Instituto Nacional de SaúdeMarques, José GonçaloInácio Cunha, Florbela MariaBajanca-Lavado, Maria PaulaPortuguese Study Group on Haemophilus influenzae Invasive Disease in Children2024-02-05T14:31:48Z2023-09-012023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/9034engPediatr Infect Dis J. 2023 Sep 1;42(9):824-828. doi: 10.1097/INF.0000000000004011. Epub 2023 Jun 30. Multicenter Study0891-366810.1097/INF.0000000000004011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-10T01:30:55Zoai:repositorio.insa.pt:10400.18/9034Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:37:22.947929Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
title Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
spellingShingle Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
Marques, José Gonçalo
Haemophilus influenzae
Serotype
Hib
Vaccine Failure
Paediatric Infections
Invasive Disease
Infecções Respiratórias
Portugal
title_short Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
title_full Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
title_fullStr Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
title_full_unstemmed Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
title_sort Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey
author Marques, José Gonçalo
author_facet Marques, José Gonçalo
Inácio Cunha, Florbela Maria
Bajanca-Lavado, Maria Paula
Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children
author_role author
author2 Inácio Cunha, Florbela Maria
Bajanca-Lavado, Maria Paula
Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Marques, José Gonçalo
Inácio Cunha, Florbela Maria
Bajanca-Lavado, Maria Paula
Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children
dc.subject.por.fl_str_mv Haemophilus influenzae
Serotype
Hib
Vaccine Failure
Paediatric Infections
Invasive Disease
Infecções Respiratórias
Portugal
topic Haemophilus influenzae
Serotype
Hib
Vaccine Failure
Paediatric Infections
Invasive Disease
Infecções Respiratórias
Portugal
description Portuguese Study Group on Haemophilus influenzae Invasive Disease in Children: Celia Bettencourt, Arminda Maria Jorge, Maria Conceição Faria, Carla Zilhão, Laura Marques, Conceição Casanova, Cristiana Pereira, Fernando Fonseca, Cláudia Monteiro, Mariana Bettencourt, Diana Moreira, Fernanda Rodrigues, Henrique Oliveira, Catarina Sousa, Graciete Pinheiro, Sara Diogo Santos, Adília Vicente, Tiago Milheiro, Margarida Pinto, Graça Seves, Rosa Bento, M ª João Virtuoso, Rita Fonseca, Maria Dinah Carvalho, Luís Lito, Carla Cruz, Adriana Coutinho, Paula Correia, Luísa Sancho, Elzara Aliyeva, Cristina Freitas, Nuno Canhoto, Ana Filipa Nunes, Ana Maria Queiroz, José Diogo, Maria Manuel Flores, Paula Reis, Elmano Ramalheira, Maria Manuel Zarcos, Sofia Lima, Susana Castilho, Catarina Lacerda, Luísa Teixeira, Ana Maria Jesus, Sofia Maia Aroso, Margarida Tavares, Bonito Vitor, Angélica Ramos, Manuela Costa Alves, Isabel Cunha, Alberta Faustino, Álvaro Sousa, Margarida Rodrigues, Idalina Maciel, Sandra Vieira, Jorge Rodrigues, Elisabete Santos, Alexandra Costa, Filomena Martins, Carlos Escobar, Pedro Flores, Maria Favila Menezes, João Calado Nunes, Ana Neto, Marina Soares, Rita Mouro Pinto, Diana Almeida, Isabel Brito, Hermínia Costa, Fátima Silva, Joana Cardoso, Magalys Pereira, Luís Gonçalves, João Tavares, Sofia Botelho Moniz, Eurico Jorge Gaspar, Joana Carvalho, Ana Paula Castro, Álvaro Sousa, Catarina Francisco, João Farela Neves, Paulo Paixão
publishDate 2023
dc.date.none.fl_str_mv 2023-09-01
2023-09-01T00:00:00Z
2024-02-05T14:31:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/9034
url http://hdl.handle.net/10400.18/9034
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pediatr Infect Dis J. 2023 Sep 1;42(9):824-828. doi: 10.1097/INF.0000000000004011. Epub 2023 Jun 30. Multicenter Study
0891-3668
10.1097/INF.0000000000004011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137424804151296

Registros relacionados