An overview of the spindle assembly checkpoint status in oral cancer
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/12041 |
Resumo: | Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is compromised in many cancers. While mutations are rather rare, many tumors show altered expression levels of SAC components. Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown. Yet, our knowledge on the status of SAC components in oral cancer remains sparse. In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20. |
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An overview of the spindle assembly checkpoint status in oral cancerSquamous-cell carcinomaAurora-B expressionMitotic checkpointChromosomal instabilityCenp-EKinetochore localizationMolecular pathogenesisHuman-papillomavirusTumor-suppressorBubr1Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is compromised in many cancers. While mutations are rather rare, many tumors show altered expression levels of SAC components. Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown. Yet, our knowledge on the status of SAC components in oral cancer remains sparse. In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20.CESPU [02-GCQF-CICS-2011N, 01-GCD-CICS-09; 02-GCD-CICS-09, 05-GCD-CICS-2011]; Fundacao para a Ciencia e a Tecnologia (FCT) [CEQUIMED-PEst-OE/SAU/UI4040/2011];Hindawi Publishing CorporationSapientiaTeixeira, Jose HenriqueSilva, PatríciaReis, Rita MargaridaMoura, Ines MoranguinhoMarques, SandraFonseca, JoanaMonteiro, Luis SilvaBousbaa, Hassan2018-12-07T14:58:28Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/12041eng2314-613310.1155/2014/145289info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:58Zoai:sapientia.ualg.pt:10400.1/12041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:27.586072Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An overview of the spindle assembly checkpoint status in oral cancer |
title |
An overview of the spindle assembly checkpoint status in oral cancer |
spellingShingle |
An overview of the spindle assembly checkpoint status in oral cancer Teixeira, Jose Henrique Squamous-cell carcinoma Aurora-B expression Mitotic checkpoint Chromosomal instability Cenp-E Kinetochore localization Molecular pathogenesis Human-papillomavirus Tumor-suppressor Bubr1 |
title_short |
An overview of the spindle assembly checkpoint status in oral cancer |
title_full |
An overview of the spindle assembly checkpoint status in oral cancer |
title_fullStr |
An overview of the spindle assembly checkpoint status in oral cancer |
title_full_unstemmed |
An overview of the spindle assembly checkpoint status in oral cancer |
title_sort |
An overview of the spindle assembly checkpoint status in oral cancer |
author |
Teixeira, Jose Henrique |
author_facet |
Teixeira, Jose Henrique Silva, Patrícia Reis, Rita Margarida Moura, Ines Moranguinho Marques, Sandra Fonseca, Joana Monteiro, Luis Silva Bousbaa, Hassan |
author_role |
author |
author2 |
Silva, Patrícia Reis, Rita Margarida Moura, Ines Moranguinho Marques, Sandra Fonseca, Joana Monteiro, Luis Silva Bousbaa, Hassan |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Teixeira, Jose Henrique Silva, Patrícia Reis, Rita Margarida Moura, Ines Moranguinho Marques, Sandra Fonseca, Joana Monteiro, Luis Silva Bousbaa, Hassan |
dc.subject.por.fl_str_mv |
Squamous-cell carcinoma Aurora-B expression Mitotic checkpoint Chromosomal instability Cenp-E Kinetochore localization Molecular pathogenesis Human-papillomavirus Tumor-suppressor Bubr1 |
topic |
Squamous-cell carcinoma Aurora-B expression Mitotic checkpoint Chromosomal instability Cenp-E Kinetochore localization Molecular pathogenesis Human-papillomavirus Tumor-suppressor Bubr1 |
description |
Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is compromised in many cancers. While mutations are rather rare, many tumors show altered expression levels of SAC components. Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown. Yet, our knowledge on the status of SAC components in oral cancer remains sparse. In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2018-12-07T14:58:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/12041 |
url |
http://hdl.handle.net/10400.1/12041 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2314-6133 10.1155/2014/145289 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133268918927360 |