Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa

Detalhes bibliográficos
Autor(a) principal: Garzón, Marisol
Data de Publicação: 2018
Outros Autores: Pereira-da-Silva, Luís, Seixas, Jorge, Papoila, Ana Luísa, Alves, Marta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/38252
Resumo: This study is part of a PhD thesis performed at the Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisbon, Portugal by one of the authors (Marisol Garzón), supervised andco-supervised by two authors (Luis Pereira-da-Silva and Jorge Seixas, respectively). The authors are very grateful to Sónia Centeno Lima, PhD, the former PhD thesis supervisor, for her valuable contributions to the design and implementation of the study; to Ana Reis, laboratory technician, for her double-check, independent microscopic examination; and to the non-governmental organization Marquês de Valle Flôr Institute, namely, Paulo Telles de Freitas, Ahmed Zaky, Edgar Neves, and António Lima, for the logistic local support. Funding: This study is supported by the Fundação para a Ciência e Tecnologia [Grant number SFRH/BD/81431/2011].
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spelling Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, AfricaA Birth Cohort Studybirth cohortenteric parasitic infectioninfant growthlow-middle-income countrysubclinical infectionSDG 3 - Good Health and Well-beingThis study is part of a PhD thesis performed at the Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisbon, Portugal by one of the authors (Marisol Garzón), supervised andco-supervised by two authors (Luis Pereira-da-Silva and Jorge Seixas, respectively). The authors are very grateful to Sónia Centeno Lima, PhD, the former PhD thesis supervisor, for her valuable contributions to the design and implementation of the study; to Ana Reis, laboratory technician, for her double-check, independent microscopic examination; and to the non-governmental organization Marquês de Valle Flôr Institute, namely, Paulo Telles de Freitas, Ahmed Zaky, Edgar Neves, and António Lima, for the logistic local support. Funding: This study is supported by the Fundação para a Ciência e Tecnologia [Grant number SFRH/BD/81431/2011].The associations between enteric pathogenic parasites and growth in infants in São Tomé were explored using a refined anthropometric approach to recognize early growth faltering. A birth cohort study was conducted with follow-up to 24 months of age. Microscopic examination for protozoa and soil-transmitted helminths was performed. Anthropometric assessments included: z-scores for weight-for-length (WLZ), length-for-age (LAZ), weight (WAVZ) and length velocities (LAVZ), length-for-age difference (LAD), and wasting and stunting risk (≤-1 SD). Generalized additive mixed effects regression models were used to explore the associations between anthropometric parameters and enteric parasitic infections and cofactors. A total of 475 infants were enrolled, and 282 completed the study. The great majority of infants were asymptomatic. Giardia lamblia was detected in 35.1% of infants in at least one stool sample, helminths in 30.4%, and Cryptosporidium spp. in 14.7%. Giardia lamblia and helminth infections were significantly associated with mean decreases of 0.10 in LAZ and 0.32 in LAD, and of 0.16 in LAZ and 0.48 in LAD, respectively. Cryptosporidium spp. infection was significantly associated with a mean decrease of 0.43 in WAVZ and 0.55 in LAVZ. The underestimated association between subclinical parasitic enteric infections and mild growth faltering in infants should be addressed in public health policies.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNGarzón, MarisolPereira-da-Silva, LuísSeixas, JorgePapoila, Ana LuísaAlves, Marta2018-05-30T22:06:50Z2018-04-052018-04-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/38252eng1660-4601PURE: 4279419https://doi.org/10.3390/ijerph15040688info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:21:11Zoai:run.unl.pt:10362/38252Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:59.350800Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
A Birth Cohort Study
title Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
spellingShingle Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
Garzón, Marisol
birth cohort
enteric parasitic infection
infant growth
low-middle-income country
subclinical infection
SDG 3 - Good Health and Well-being
title_short Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
title_full Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
title_fullStr Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
title_full_unstemmed Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
title_sort Subclinical Enteric Parasitic Infections and Growth Faltering in Infants in São Tomé, Africa
author Garzón, Marisol
author_facet Garzón, Marisol
Pereira-da-Silva, Luís
Seixas, Jorge
Papoila, Ana Luísa
Alves, Marta
author_role author
author2 Pereira-da-Silva, Luís
Seixas, Jorge
Papoila, Ana Luísa
Alves, Marta
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
RUN
dc.contributor.author.fl_str_mv Garzón, Marisol
Pereira-da-Silva, Luís
Seixas, Jorge
Papoila, Ana Luísa
Alves, Marta
dc.subject.por.fl_str_mv birth cohort
enteric parasitic infection
infant growth
low-middle-income country
subclinical infection
SDG 3 - Good Health and Well-being
topic birth cohort
enteric parasitic infection
infant growth
low-middle-income country
subclinical infection
SDG 3 - Good Health and Well-being
description This study is part of a PhD thesis performed at the Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisbon, Portugal by one of the authors (Marisol Garzón), supervised andco-supervised by two authors (Luis Pereira-da-Silva and Jorge Seixas, respectively). The authors are very grateful to Sónia Centeno Lima, PhD, the former PhD thesis supervisor, for her valuable contributions to the design and implementation of the study; to Ana Reis, laboratory technician, for her double-check, independent microscopic examination; and to the non-governmental organization Marquês de Valle Flôr Institute, namely, Paulo Telles de Freitas, Ahmed Zaky, Edgar Neves, and António Lima, for the logistic local support. Funding: This study is supported by the Fundação para a Ciência e Tecnologia [Grant number SFRH/BD/81431/2011].
publishDate 2018
dc.date.none.fl_str_mv 2018-05-30T22:06:50Z
2018-04-05
2018-04-05T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/38252
url http://hdl.handle.net/10362/38252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-4601
PURE: 4279419
https://doi.org/10.3390/ijerph15040688
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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