Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort

Detalhes bibliográficos
Autor(a) principal: Vollstedt, Eva‐Juliane
Data de Publicação: 2023
Outros Autores: Schaake, Susen, Lohmann, Katja, Padmanabhan, Shalini, Brice, Alexis, Lesage, Suzanne, Tesson, Christelle, Vidailhet, Marie, Wurster, Isabel, Hentati, Faycel, Mirelman, Anat, Zhang, Bao‐rong, Garraux, Gaetan, Chung, Sun Ju, Kim, Yun Joong, Winkelmann, Juliane, Sue, Carolyn M., Tan, Eng‐King, Damásio, Joana, Klivényi, Péter, Kostic, Vladimir S., Giladi, Nir, Arkadir, David, Martikainen, Mika, Borges, Vanderci, Hertz, Jens Michael, Brighina, Laura, Spitz, Mariana, Suchowersky, Oksana, Riess, Olaf, Das, Parimal, Mollenhauer, Brit, Marder, Karen, Gatto, Emilia M., Petersen, Maria Skaalum, Hattori, Nobutaka, Wu, Ruey‐Meei, Illarioshkin, Sergey N., Valente, Enza Maria, Aasly, Jan O., Aasly, Anna, Alcalay, Roy N., Thaler, Avner, Waters, Cheryl, Farrer, Matthew J., Brockmann, Kathrin, Corvol, Jean‐Christophe, Klein, Christine, Fahn, Stanley, Kasten, Meike, Brüggemann, Norbert, Borsche, Max, Foroud, Tatiana, Tolosa, Eduardo, Garrido, Alicia, Annesi, Grazia, Gagliardi, Monica, Bozi, Maria, Stefanis, Leonidas, Ferreira, Joaquim J, Correia Guedes, Leonor, Avenali, Micol, Petrucci, Simona, Clark, Lorraine, Fedotova, Ekaterina Y., Abramycheva, Natalya Y., Alvarez, Victoria, Menéndez‐González, Manuel, Jesús Maestre, Silvia, Gómez‐Garre, Pilar, Mir, Pablo, Belin, Andrea Carmine, Ran, Caroline, Lin, Chin‐Hsien, Kuo, Ming‐Che, Crosiers, David, Wszolek, Zbigniew K., Ross, Owen A., Jankovic, Joseph, Nishioka, Kenya, Funayama, Manabu, Clarimon, Jordi, Williams‐Gray, Caroline H., Camacho, Marta, Cornejo‐Olivas, Mario, Torres‐Ramirez, Luis, Wu, Yih‐Ru, Lee‐Chen, Guey‐Jen, Morgadinho, Ana, Pulkes, Teeratorn, Termsarasab, Pichet, Berg, Daniela, Kuhlenbäumer, Gregor, Kühn, Andrea A., Borngräber, Friederike, de Michele, Giuseppe, De Rosa, Anna, Zimprich, Alexander, Puschmann, Andreas, Mellick, George D., Dorszewska, Jolanta, Carr, Jonathan, Ferese, Rosangela, Gambardella, Stefano, Chase, Bruce, Markopoulou, Katerina, Satake, Wataru, Toda, Tatsushi, Rossi, Malco, Merello, Marcelo, Lynch, Timothy, Olszewska, Diana A., Lim, Shen‐Yang, Ahmad‐Annuar, Azlina, Tan, Ai Huey, Al‐Mubarak, Bashayer, Hanagasi, Hasmet, Koziorowski, Dariusz, Ertan, Sibel, Genç, Gençer, de Carvalho Aguiar, Patricia, Barkhuizen, Melinda, Pimentel, Marcia M.G., Saunders‐Pullman, Rachel, van de Warrenburg, Bart, Bressman, Susan, Toft, Mathias, Appel‐Cresswell, Silke, Lang, Anthony E., Skorvanek, Matej, Boon, Agnita J.W., Krüger, Rejko, Sammler, Esther M., Tumas, Vitor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56042
Resumo: © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
id RCAP_80b12ce1b00af6305b8dc3d02c858c21
oai_identifier_str oai:repositorio.ul.pt:10451/56042
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD CohortParkinson's diseaseMonogenic PD© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014WileyRepositório da Universidade de LisboaVollstedt, Eva‐JulianeSchaake, SusenLohmann, KatjaPadmanabhan, ShaliniBrice, AlexisLesage, SuzanneTesson, ChristelleVidailhet, MarieWurster, IsabelHentati, FaycelMirelman, AnatZhang, Bao‐rongGarraux, GaetanChung, Sun JuKim, Yun JoongWinkelmann, JulianeSue, Carolyn M.Tan, Eng‐KingDamásio, JoanaKlivényi, PéterKostic, Vladimir S.Giladi, NirArkadir, DavidMartikainen, MikaBorges, VanderciHertz, Jens MichaelBrighina, LauraSpitz, MarianaSuchowersky, OksanaRiess, OlafDas, ParimalMollenhauer, BritMarder, KarenGatto, Emilia M.Petersen, Maria SkaalumHattori, NobutakaWu, Ruey‐MeeiIllarioshkin, Sergey N.Valente, Enza MariaAasly, Jan O.Aasly, AnnaAlcalay, Roy N.Thaler, AvnerWaters, CherylFarrer, Matthew J.Brockmann, KathrinCorvol, Jean‐ChristopheKlein, ChristineFahn, StanleyKasten, MeikeBrüggemann, NorbertBorsche, MaxForoud, TatianaTolosa, EduardoGarrido, AliciaAnnesi, GraziaGagliardi, MonicaBozi, MariaStefanis, LeonidasFerreira, Joaquim JCorreia Guedes, LeonorAvenali, MicolPetrucci, SimonaClark, LorraineFedotova, Ekaterina Y.Abramycheva, Natalya Y.Alvarez, VictoriaMenéndez‐González, ManuelJesús Maestre, SilviaGómez‐Garre, PilarMir, PabloBelin, Andrea CarmineRan, CarolineLin, Chin‐HsienKuo, Ming‐CheCrosiers, DavidWszolek, Zbigniew K.Ross, Owen A.Jankovic, JosephNishioka, KenyaFunayama, ManabuClarimon, JordiWilliams‐Gray, Caroline H.Camacho, MartaCornejo‐Olivas, MarioTorres‐Ramirez, LuisWu, Yih‐RuLee‐Chen, Guey‐JenMorgadinho, AnaPulkes, TeeratornTermsarasab, PichetBerg, DanielaKuhlenbäumer, GregorKühn, Andrea A.Borngräber, Friederikede Michele, GiuseppeDe Rosa, AnnaZimprich, AlexanderPuschmann, AndreasMellick, George D.Dorszewska, JolantaCarr, JonathanFerese, RosangelaGambardella, StefanoChase, BruceMarkopoulou, KaterinaSatake, WataruToda, TatsushiRossi, MalcoMerello, MarceloLynch, TimothyOlszewska, Diana A.Lim, Shen‐YangAhmad‐Annuar, AzlinaTan, Ai HueyAl‐Mubarak, BashayerHanagasi, HasmetKoziorowski, DariuszErtan, SibelGenç, Gençerde Carvalho Aguiar, PatriciaBarkhuizen, MelindaPimentel, Marcia M.G.Saunders‐Pullman, Rachelvan de Warrenburg, BartBressman, SusanToft, MathiasAppel‐Cresswell, SilkeLang, Anthony E.Skorvanek, MatejBoon, Agnita J.W.Krüger, RejkoSammler, Esther M.Tumas, Vitor2023-01-27T15:17:01Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56042engMov Disord. 2023 Jan 240885-318510.1002/mds.292881531-8257info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:19:06Zoai:repositorio.ul.pt:10451/56042Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:19:06Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
title Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
spellingShingle Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
Vollstedt, Eva‐Juliane
Parkinson's disease
Monogenic PD
title_short Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
title_full Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
title_fullStr Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
title_full_unstemmed Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
title_sort Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort
author Vollstedt, Eva‐Juliane
author_facet Vollstedt, Eva‐Juliane
Schaake, Susen
Lohmann, Katja
Padmanabhan, Shalini
Brice, Alexis
Lesage, Suzanne
Tesson, Christelle
Vidailhet, Marie
Wurster, Isabel
Hentati, Faycel
Mirelman, Anat
Zhang, Bao‐rong
Garraux, Gaetan
Chung, Sun Ju
Kim, Yun Joong
Winkelmann, Juliane
Sue, Carolyn M.
Tan, Eng‐King
Damásio, Joana
Klivényi, Péter
Kostic, Vladimir S.
Giladi, Nir
Arkadir, David
Martikainen, Mika
Borges, Vanderci
Hertz, Jens Michael
Brighina, Laura
Spitz, Mariana
Suchowersky, Oksana
Riess, Olaf
Das, Parimal
Mollenhauer, Brit
Marder, Karen
Gatto, Emilia M.
Petersen, Maria Skaalum
Hattori, Nobutaka
Wu, Ruey‐Meei
Illarioshkin, Sergey N.
Valente, Enza Maria
Aasly, Jan O.
Aasly, Anna
Alcalay, Roy N.
Thaler, Avner
Waters, Cheryl
Farrer, Matthew J.
Brockmann, Kathrin
Corvol, Jean‐Christophe
Klein, Christine
Fahn, Stanley
Kasten, Meike
Brüggemann, Norbert
Borsche, Max
Foroud, Tatiana
Tolosa, Eduardo
Garrido, Alicia
Annesi, Grazia
Gagliardi, Monica
Bozi, Maria
Stefanis, Leonidas
Ferreira, Joaquim J
Correia Guedes, Leonor
Avenali, Micol
Petrucci, Simona
Clark, Lorraine
Fedotova, Ekaterina Y.
Abramycheva, Natalya Y.
Alvarez, Victoria
Menéndez‐González, Manuel
Jesús Maestre, Silvia
Gómez‐Garre, Pilar
Mir, Pablo
Belin, Andrea Carmine
Ran, Caroline
Lin, Chin‐Hsien
Kuo, Ming‐Che
Crosiers, David
Wszolek, Zbigniew K.
Ross, Owen A.
Jankovic, Joseph
Nishioka, Kenya
Funayama, Manabu
Clarimon, Jordi
Williams‐Gray, Caroline H.
Camacho, Marta
Cornejo‐Olivas, Mario
Torres‐Ramirez, Luis
Wu, Yih‐Ru
Lee‐Chen, Guey‐Jen
Morgadinho, Ana
Pulkes, Teeratorn
Termsarasab, Pichet
Berg, Daniela
Kuhlenbäumer, Gregor
Kühn, Andrea A.
Borngräber, Friederike
de Michele, Giuseppe
De Rosa, Anna
Zimprich, Alexander
Puschmann, Andreas
Mellick, George D.
Dorszewska, Jolanta
Carr, Jonathan
Ferese, Rosangela
Gambardella, Stefano
Chase, Bruce
Markopoulou, Katerina
Satake, Wataru
Toda, Tatsushi
Rossi, Malco
Merello, Marcelo
Lynch, Timothy
Olszewska, Diana A.
Lim, Shen‐Yang
Ahmad‐Annuar, Azlina
Tan, Ai Huey
Al‐Mubarak, Bashayer
Hanagasi, Hasmet
Koziorowski, Dariusz
Ertan, Sibel
Genç, Gençer
de Carvalho Aguiar, Patricia
Barkhuizen, Melinda
Pimentel, Marcia M.G.
Saunders‐Pullman, Rachel
van de Warrenburg, Bart
Bressman, Susan
Toft, Mathias
Appel‐Cresswell, Silke
Lang, Anthony E.
Skorvanek, Matej
Boon, Agnita J.W.
Krüger, Rejko
Sammler, Esther M.
Tumas, Vitor
author_role author
author2 Schaake, Susen
Lohmann, Katja
Padmanabhan, Shalini
Brice, Alexis
Lesage, Suzanne
Tesson, Christelle
Vidailhet, Marie
Wurster, Isabel
Hentati, Faycel
Mirelman, Anat
Zhang, Bao‐rong
Garraux, Gaetan
Chung, Sun Ju
Kim, Yun Joong
Winkelmann, Juliane
Sue, Carolyn M.
Tan, Eng‐King
Damásio, Joana
Klivényi, Péter
Kostic, Vladimir S.
Giladi, Nir
Arkadir, David
Martikainen, Mika
Borges, Vanderci
Hertz, Jens Michael
Brighina, Laura
Spitz, Mariana
Suchowersky, Oksana
Riess, Olaf
Das, Parimal
Mollenhauer, Brit
Marder, Karen
Gatto, Emilia M.
Petersen, Maria Skaalum
Hattori, Nobutaka
Wu, Ruey‐Meei
Illarioshkin, Sergey N.
Valente, Enza Maria
Aasly, Jan O.
Aasly, Anna
Alcalay, Roy N.
Thaler, Avner
Waters, Cheryl
Farrer, Matthew J.
Brockmann, Kathrin
Corvol, Jean‐Christophe
Klein, Christine
Fahn, Stanley
Kasten, Meike
Brüggemann, Norbert
Borsche, Max
Foroud, Tatiana
Tolosa, Eduardo
Garrido, Alicia
Annesi, Grazia
Gagliardi, Monica
Bozi, Maria
Stefanis, Leonidas
Ferreira, Joaquim J
Correia Guedes, Leonor
Avenali, Micol
Petrucci, Simona
Clark, Lorraine
Fedotova, Ekaterina Y.
Abramycheva, Natalya Y.
Alvarez, Victoria
Menéndez‐González, Manuel
Jesús Maestre, Silvia
Gómez‐Garre, Pilar
Mir, Pablo
Belin, Andrea Carmine
Ran, Caroline
Lin, Chin‐Hsien
Kuo, Ming‐Che
Crosiers, David
Wszolek, Zbigniew K.
Ross, Owen A.
Jankovic, Joseph
Nishioka, Kenya
Funayama, Manabu
Clarimon, Jordi
Williams‐Gray, Caroline H.
Camacho, Marta
Cornejo‐Olivas, Mario
Torres‐Ramirez, Luis
Wu, Yih‐Ru
Lee‐Chen, Guey‐Jen
Morgadinho, Ana
Pulkes, Teeratorn
Termsarasab, Pichet
Berg, Daniela
Kuhlenbäumer, Gregor
Kühn, Andrea A.
Borngräber, Friederike
de Michele, Giuseppe
De Rosa, Anna
Zimprich, Alexander
Puschmann, Andreas
Mellick, George D.
Dorszewska, Jolanta
Carr, Jonathan
Ferese, Rosangela
Gambardella, Stefano
Chase, Bruce
Markopoulou, Katerina
Satake, Wataru
Toda, Tatsushi
Rossi, Malco
Merello, Marcelo
Lynch, Timothy
Olszewska, Diana A.
Lim, Shen‐Yang
Ahmad‐Annuar, Azlina
Tan, Ai Huey
Al‐Mubarak, Bashayer
Hanagasi, Hasmet
Koziorowski, Dariusz
Ertan, Sibel
Genç, Gençer
de Carvalho Aguiar, Patricia
Barkhuizen, Melinda
Pimentel, Marcia M.G.
Saunders‐Pullman, Rachel
van de Warrenburg, Bart
Bressman, Susan
Toft, Mathias
Appel‐Cresswell, Silke
Lang, Anthony E.
Skorvanek, Matej
Boon, Agnita J.W.
Krüger, Rejko
Sammler, Esther M.
Tumas, Vitor
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Vollstedt, Eva‐Juliane
Schaake, Susen
Lohmann, Katja
Padmanabhan, Shalini
Brice, Alexis
Lesage, Suzanne
Tesson, Christelle
Vidailhet, Marie
Wurster, Isabel
Hentati, Faycel
Mirelman, Anat
Zhang, Bao‐rong
Garraux, Gaetan
Chung, Sun Ju
Kim, Yun Joong
Winkelmann, Juliane
Sue, Carolyn M.
Tan, Eng‐King
Damásio, Joana
Klivényi, Péter
Kostic, Vladimir S.
Giladi, Nir
Arkadir, David
Martikainen, Mika
Borges, Vanderci
Hertz, Jens Michael
Brighina, Laura
Spitz, Mariana
Suchowersky, Oksana
Riess, Olaf
Das, Parimal
Mollenhauer, Brit
Marder, Karen
Gatto, Emilia M.
Petersen, Maria Skaalum
Hattori, Nobutaka
Wu, Ruey‐Meei
Illarioshkin, Sergey N.
Valente, Enza Maria
Aasly, Jan O.
Aasly, Anna
Alcalay, Roy N.
Thaler, Avner
Waters, Cheryl
Farrer, Matthew J.
Brockmann, Kathrin
Corvol, Jean‐Christophe
Klein, Christine
Fahn, Stanley
Kasten, Meike
Brüggemann, Norbert
Borsche, Max
Foroud, Tatiana
Tolosa, Eduardo
Garrido, Alicia
Annesi, Grazia
Gagliardi, Monica
Bozi, Maria
Stefanis, Leonidas
Ferreira, Joaquim J
Correia Guedes, Leonor
Avenali, Micol
Petrucci, Simona
Clark, Lorraine
Fedotova, Ekaterina Y.
Abramycheva, Natalya Y.
Alvarez, Victoria
Menéndez‐González, Manuel
Jesús Maestre, Silvia
Gómez‐Garre, Pilar
Mir, Pablo
Belin, Andrea Carmine
Ran, Caroline
Lin, Chin‐Hsien
Kuo, Ming‐Che
Crosiers, David
Wszolek, Zbigniew K.
Ross, Owen A.
Jankovic, Joseph
Nishioka, Kenya
Funayama, Manabu
Clarimon, Jordi
Williams‐Gray, Caroline H.
Camacho, Marta
Cornejo‐Olivas, Mario
Torres‐Ramirez, Luis
Wu, Yih‐Ru
Lee‐Chen, Guey‐Jen
Morgadinho, Ana
Pulkes, Teeratorn
Termsarasab, Pichet
Berg, Daniela
Kuhlenbäumer, Gregor
Kühn, Andrea A.
Borngräber, Friederike
de Michele, Giuseppe
De Rosa, Anna
Zimprich, Alexander
Puschmann, Andreas
Mellick, George D.
Dorszewska, Jolanta
Carr, Jonathan
Ferese, Rosangela
Gambardella, Stefano
Chase, Bruce
Markopoulou, Katerina
Satake, Wataru
Toda, Tatsushi
Rossi, Malco
Merello, Marcelo
Lynch, Timothy
Olszewska, Diana A.
Lim, Shen‐Yang
Ahmad‐Annuar, Azlina
Tan, Ai Huey
Al‐Mubarak, Bashayer
Hanagasi, Hasmet
Koziorowski, Dariusz
Ertan, Sibel
Genç, Gençer
de Carvalho Aguiar, Patricia
Barkhuizen, Melinda
Pimentel, Marcia M.G.
Saunders‐Pullman, Rachel
van de Warrenburg, Bart
Bressman, Susan
Toft, Mathias
Appel‐Cresswell, Silke
Lang, Anthony E.
Skorvanek, Matej
Boon, Agnita J.W.
Krüger, Rejko
Sammler, Esther M.
Tumas, Vitor
dc.subject.por.fl_str_mv Parkinson's disease
Monogenic PD
topic Parkinson's disease
Monogenic PD
description © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-27T15:17:01Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56042
url http://hdl.handle.net/10451/56042
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mov Disord. 2023 Jan 24
0885-3185
10.1002/mds.29288
1531-8257
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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