Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/87529 |
Resumo: | The global concern over the emergence of antibiotic-resistant pathogens is growing, demanding for new and more effective antimicrobial strategies. Antimicrobial peptides (AMPs) have been the focus of great interest as alternatives to antibiotics. Nisin, a naturally occurring AMP, possesses unique characteristics such as an uncommon structure, amphiphilic nature, low likelihood of promoting bacterial resistance, and strong bactericidal activity against a wide range of pathogenic microorganisms. Moreover, it displays low cytotoxicity and is considered safe for human consumption. Thus, nisin shows potential as an alternative antimicrobial treatment. However, certain physicochemical properties, including low solubility and stability at physiological pH, may hinder peptide’s efficacy in vivo. For this reason, the combination of nisin with other bioactive molecules has received considerable attention as a promising approach to enhance the peptide’s antimicrobial efficacy in clinical applications. This comprehensive review examines the effect of nisin when combined with other AMPs, traditional antibiotics, anticancer agents, natural extracts, biopolymers and nanomaterials. Additive and synergistic interactions are highlighted, as well as these molecules potential applications in the biomedical field, shedding a light on the future of these promising combinations. |
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Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a reviewEngenharia e Tecnologia::Engenharia MédicaThe global concern over the emergence of antibiotic-resistant pathogens is growing, demanding for new and more effective antimicrobial strategies. Antimicrobial peptides (AMPs) have been the focus of great interest as alternatives to antibiotics. Nisin, a naturally occurring AMP, possesses unique characteristics such as an uncommon structure, amphiphilic nature, low likelihood of promoting bacterial resistance, and strong bactericidal activity against a wide range of pathogenic microorganisms. Moreover, it displays low cytotoxicity and is considered safe for human consumption. Thus, nisin shows potential as an alternative antimicrobial treatment. However, certain physicochemical properties, including low solubility and stability at physiological pH, may hinder peptide’s efficacy in vivo. For this reason, the combination of nisin with other bioactive molecules has received considerable attention as a promising approach to enhance the peptide’s antimicrobial efficacy in clinical applications. This comprehensive review examines the effect of nisin when combined with other AMPs, traditional antibiotics, anticancer agents, natural extracts, biopolymers and nanomaterials. Additive and synergistic interactions are highlighted, as well as these molecules potential applications in the biomedical field, shedding a light on the future of these promising combinations.This research was funded by the Portuguese Foundation for Science and Technology (FCT) via grant UIDP/00264/2020 of 2C2T Strategic Project 2020-2023. T.D.T. and A.R.M.R. also acknowledge FCT for PhD scholarships 2020.06046.BD and 2021.08627.BD, respectively. H.P.F. acknowledges FCT for Auxiliary Researcher contract 2021.02720.CEECIND.ElsevierUniversidade do MinhoTavares, Tânia Daniela EugénioRibeiro, Ana R. M.Silva, Carla Joana Santos MarinhoAntunes, Joana Isabel CostaFelgueiras, Helena Prado2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/87529engTavares, T. D., Ribeiro, A. R. M., Silva, C., Antunes, J. C., & Felgueiras, H. P. (2024, January). Combinatory effect of nisin antimicrobial peptide with bioactive molecules: A review. Journal of Drug Delivery Science and Technology. Elsevier BV. http://doi.org/10.1016/j.jddst.2023.1052461773-224710.1016/j.jddst.2023.105246https://www.sciencedirect.com/science/article/pii/S1773224723010985info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-16T01:20:20Zoai:repositorium.sdum.uminho.pt:1822/87529Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:54:23.008683Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
title |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
spellingShingle |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review Tavares, Tânia Daniela Eugénio Engenharia e Tecnologia::Engenharia Médica |
title_short |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
title_full |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
title_fullStr |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
title_full_unstemmed |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
title_sort |
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a review |
author |
Tavares, Tânia Daniela Eugénio |
author_facet |
Tavares, Tânia Daniela Eugénio Ribeiro, Ana R. M. Silva, Carla Joana Santos Marinho Antunes, Joana Isabel Costa Felgueiras, Helena Prado |
author_role |
author |
author2 |
Ribeiro, Ana R. M. Silva, Carla Joana Santos Marinho Antunes, Joana Isabel Costa Felgueiras, Helena Prado |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Tavares, Tânia Daniela Eugénio Ribeiro, Ana R. M. Silva, Carla Joana Santos Marinho Antunes, Joana Isabel Costa Felgueiras, Helena Prado |
dc.subject.por.fl_str_mv |
Engenharia e Tecnologia::Engenharia Médica |
topic |
Engenharia e Tecnologia::Engenharia Médica |
description |
The global concern over the emergence of antibiotic-resistant pathogens is growing, demanding for new and more effective antimicrobial strategies. Antimicrobial peptides (AMPs) have been the focus of great interest as alternatives to antibiotics. Nisin, a naturally occurring AMP, possesses unique characteristics such as an uncommon structure, amphiphilic nature, low likelihood of promoting bacterial resistance, and strong bactericidal activity against a wide range of pathogenic microorganisms. Moreover, it displays low cytotoxicity and is considered safe for human consumption. Thus, nisin shows potential as an alternative antimicrobial treatment. However, certain physicochemical properties, including low solubility and stability at physiological pH, may hinder peptide’s efficacy in vivo. For this reason, the combination of nisin with other bioactive molecules has received considerable attention as a promising approach to enhance the peptide’s antimicrobial efficacy in clinical applications. This comprehensive review examines the effect of nisin when combined with other AMPs, traditional antibiotics, anticancer agents, natural extracts, biopolymers and nanomaterials. Additive and synergistic interactions are highlighted, as well as these molecules potential applications in the biomedical field, shedding a light on the future of these promising combinations. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01 2024-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/87529 |
url |
https://hdl.handle.net/1822/87529 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tavares, T. D., Ribeiro, A. R. M., Silva, C., Antunes, J. C., & Felgueiras, H. P. (2024, January). Combinatory effect of nisin antimicrobial peptide with bioactive molecules: A review. Journal of Drug Delivery Science and Technology. Elsevier BV. http://doi.org/10.1016/j.jddst.2023.105246 1773-2247 10.1016/j.jddst.2023.105246 https://www.sciencedirect.com/science/article/pii/S1773224723010985 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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