Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines

Detalhes bibliográficos
Autor(a) principal: Silva, Nelly
Data de Publicação: 2020
Outros Autores: Santos, Nuno C., Martins, Ivo C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48296
Resumo: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccinesAedesFlavivirusZikaDengueEpidemiology© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Dengue virus (DENV), which can lead to fatal hemorrhagic fever, affects 390 million people worldwide. The closely related Zika virus (ZIKV) causes microcephaly in newborns and Guillain-Barré syndrome in adults. Both viruses are mostly transmitted by Aedes albopictus and Aedes aegypti mosquitoes, which, due to globalization of trade and travel alongside climate change, are spreading worldwide, paving the way to DENV and ZIKV transmission and the occurrence of new epidemics. Local outbreaks have already occurred in temperate climates, even in Europe. As there are no specific treatments, these viruses are an international public health concern. Here, we analyze and discuss DENV and ZIKV outbreaks history, clinical and pathogenesis features, and modes of transmission, supplementing with information on advances on potential therapies and restraining measures. Taking advantage of the knowledge of the structure and biological function of the capsid (C) protein, a relatively conserved protein among flaviviruses, within a genus that includes DENV and ZIKV, we designed and patented a new drug lead, pep14-23 (WO2008/028939A1). It was demonstrated that it inhibits the interaction of DENV C protein with the host lipid system, a process essential for viral replication. Such an approach can be used to develop new therapies for related viruses, such as ZIKV.This research was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal), and Calouste Gulbenkian Foundation (FCG, Portugal) project Science Frontiers Research Prize 2010. N.M.S. acknowledges FCT-MCTES fellowship SFRH/BD/144585/2019. I.C.M. acknowledges FCT-MCTES program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).MDPIRepositório da Universidade de LisboaSilva, NellySantos, Nuno C.Martins, Ivo C.2021-06-01T14:30:26Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48296engTrop Med Infect Dis. 2020 Sep 23;5(4):15010.3390/tropicalmed50401502414-6366info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:35Zoai:repositorio.ul.pt:10451/48296Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:11.984795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
title Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
spellingShingle Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
Silva, Nelly
Aedes
Flavivirus
Zika
Dengue
Epidemiology
title_short Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
title_full Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
title_fullStr Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
title_full_unstemmed Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
title_sort Dengue and Zika viruses : epidemiological history, potential therapies, and promising vaccines
author Silva, Nelly
author_facet Silva, Nelly
Santos, Nuno C.
Martins, Ivo C.
author_role author
author2 Santos, Nuno C.
Martins, Ivo C.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Nelly
Santos, Nuno C.
Martins, Ivo C.
dc.subject.por.fl_str_mv Aedes
Flavivirus
Zika
Dengue
Epidemiology
topic Aedes
Flavivirus
Zika
Dengue
Epidemiology
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-06-01T14:30:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48296
url http://hdl.handle.net/10451/48296
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Trop Med Infect Dis. 2020 Sep 23;5(4):150
10.3390/tropicalmed5040150
2414-6366
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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