Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Detalhes bibliográficos
Autor(a) principal: Costa, Ângela
Data de Publicação: 2015
Outros Autores: Pinto, Filipe, Martinho, Olga, Oliveira, Maria José, Jordan, Peter, Reis, Rui Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3437
Resumo: Free PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359304/
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spelling Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomasVias de Transdução de Sinal e Patologias AssociadasGliomaWNK2MMP2JNKTumor SuppressorFree PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359304/Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter methylation in gliomas. Patients without WNK2 exhibited poor prognosis, and its downregulation was associated with increased glioma cell invasion. Here we showed that MMP2 expression and activity are increased in glioma cell lines that do not express WNK2. Also, WNK2 inhibited JNK, a process associated with decreasing levels of MMP2. Thus, WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential.This work was supported by a Portuguese Foundation for Science and Technology (FCT) projects PTDC/SAU-TOX/114549/2009, and PTDC-SAUONC/112511/2009. AMC is a Post-doc Fellow (PTDC/ SAU-TOX/114549/2009), and FP is a PhD Fellow (SFRH/ BD/81369/2011) from FCT. OM is a Post-doc Fellow from QREN (UMINHO/BPD/32/2013). MJO is an Investigator FCT recipient.Impact Journals, LLCRepositório Científico do Instituto Nacional de SaúdeCosta, ÂngelaPinto, FilipeMartinho, OlgaOliveira, Maria JoséJordan, PeterReis, Rui Manuel2016-02-19T12:15:44Z2015-012015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3437engOncotarget. 2015 Jan 30;6(3):1422-34. doi: 10.18632/oncotarget.28051949-255310.18632/oncotarget.2805info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:43Zoai:repositorio.insa.pt:10400.18/3437Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:12.497086Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
title Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
spellingShingle Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Costa, Ângela
Vias de Transdução de Sinal e Patologias Associadas
Glioma
WNK2
MMP2
JNK
Tumor Suppressor
title_short Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
title_full Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
title_fullStr Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
title_full_unstemmed Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
title_sort Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
author Costa, Ângela
author_facet Costa, Ângela
Pinto, Filipe
Martinho, Olga
Oliveira, Maria José
Jordan, Peter
Reis, Rui Manuel
author_role author
author2 Pinto, Filipe
Martinho, Olga
Oliveira, Maria José
Jordan, Peter
Reis, Rui Manuel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Costa, Ângela
Pinto, Filipe
Martinho, Olga
Oliveira, Maria José
Jordan, Peter
Reis, Rui Manuel
dc.subject.por.fl_str_mv Vias de Transdução de Sinal e Patologias Associadas
Glioma
WNK2
MMP2
JNK
Tumor Suppressor
topic Vias de Transdução de Sinal e Patologias Associadas
Glioma
WNK2
MMP2
JNK
Tumor Suppressor
description Free PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359304/
publishDate 2015
dc.date.none.fl_str_mv 2015-01
2015-01-01T00:00:00Z
2016-02-19T12:15:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3437
url http://hdl.handle.net/10400.18/3437
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oncotarget. 2015 Jan 30;6(3):1422-34. doi: 10.18632/oncotarget.2805
1949-2553
10.18632/oncotarget.2805
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Impact Journals, LLC
publisher.none.fl_str_mv Impact Journals, LLC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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