How two become one: HJURP dimerization drives CENP-A assembly

Detalhes bibliográficos
Autor(a) principal: Bodor, Dani L
Data de Publicação: 2013
Outros Autores: Jansen, Lars E T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/618
Resumo: CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A.
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spelling How two become one: HJURP dimerization drives CENP-A assemblyAutoantigensCentromereChromosomal Proteins, Non-HistoneDNA-Binding ProteinsHumansNucleosomesProtein MultimerizationCENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A.FCT fellowship: (SFRH/BD/74284/2010); FCT grants: (BIA-BCM/100557/2008, BIAPRO/100537/2008); EMBO Installation Grant.Embo PressARCABodor, Dani LJansen, Lars E T2016-05-24T12:22:08Z2013-06-212013-06-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/618engBodor, D. L., Jansen, L. E. T. (2013). How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32(15), 2090–2092.10.1038/emboj.2013.150info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:00Zoai:arca.igc.gulbenkian.pt:10400.7/618Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:51.772350Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How two become one: HJURP dimerization drives CENP-A assembly
title How two become one: HJURP dimerization drives CENP-A assembly
spellingShingle How two become one: HJURP dimerization drives CENP-A assembly
Bodor, Dani L
Autoantigens
Centromere
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Humans
Nucleosomes
Protein Multimerization
title_short How two become one: HJURP dimerization drives CENP-A assembly
title_full How two become one: HJURP dimerization drives CENP-A assembly
title_fullStr How two become one: HJURP dimerization drives CENP-A assembly
title_full_unstemmed How two become one: HJURP dimerization drives CENP-A assembly
title_sort How two become one: HJURP dimerization drives CENP-A assembly
author Bodor, Dani L
author_facet Bodor, Dani L
Jansen, Lars E T
author_role author
author2 Jansen, Lars E T
author2_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Bodor, Dani L
Jansen, Lars E T
dc.subject.por.fl_str_mv Autoantigens
Centromere
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Humans
Nucleosomes
Protein Multimerization
topic Autoantigens
Centromere
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Humans
Nucleosomes
Protein Multimerization
description CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-21
2013-06-21T00:00:00Z
2016-05-24T12:22:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/618
url http://hdl.handle.net/10400.7/618
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bodor, D. L., Jansen, L. E. T. (2013). How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32(15), 2090–2092.
10.1038/emboj.2013.150
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Embo Press
publisher.none.fl_str_mv Embo Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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