Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples

Detalhes bibliográficos
Autor(a) principal: Habib,I. H. I.
Data de Publicação: 2016
Outros Autores: Rizk,M. S., El-Alamin,M. M. Abou, Imam,G. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004
Resumo: Febuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.
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spelling Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma SamplesFebuxostatdifferential pulse voltammetryHMDEpharmaceutical and plasma samplesFebuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.Sociedade Portuguesa de Electroquímica2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004Portugaliae Electrochimica Acta v.34 n.5 2016reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004Habib,I. H. I.Rizk,M. S.El-Alamin,M. M. AbouImam,G. S.info:eu-repo/semantics/openAccess2024-02-06T17:07:22Zoai:scielo:S0872-19042016000500004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:18.888163Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
title Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
spellingShingle Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
Habib,I. H. I.
Febuxostat
differential pulse voltammetry
HMDE
pharmaceutical and plasma samples
title_short Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
title_full Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
title_fullStr Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
title_full_unstemmed Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
title_sort Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
author Habib,I. H. I.
author_facet Habib,I. H. I.
Rizk,M. S.
El-Alamin,M. M. Abou
Imam,G. S.
author_role author
author2 Rizk,M. S.
El-Alamin,M. M. Abou
Imam,G. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Habib,I. H. I.
Rizk,M. S.
El-Alamin,M. M. Abou
Imam,G. S.
dc.subject.por.fl_str_mv Febuxostat
differential pulse voltammetry
HMDE
pharmaceutical and plasma samples
topic Febuxostat
differential pulse voltammetry
HMDE
pharmaceutical and plasma samples
description Febuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.34 n.5 2016
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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