Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial

Detalhes bibliográficos
Autor(a) principal: Alves, J. C.
Data de Publicação: 2021
Outros Autores: Moniz Pereira dos Santos, Ana Margarida, Jorge, Patrícia, Vieira Branco Lavrador, Catarina Falcão Trigoso, Carreira, L.Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/22541
Resumo: Research Areas: Orthopedics
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spelling Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trialAnimal modelDogOsteoarthritisPainHigh molecular weight hyaluronanClinical metrology instrumentsResearch Areas: OrthopedicsBackground Osteoarthritis (OA) is a complex joint disease and chronic pain source, affecting a patient's quality of life and posing a financial burden. As the dog is considered a nearly ideal species for translation research of human OA and the most used model for research, exploring spontaneous dog OA under the One Health/One Medicine concept can improve both humans and dogs' health and well-being. Methods In a clinical treatment experiment, forty (N=40) joints were selected and randomly assigned to a control group (CG), which received 0.9% NaCl or a treatment (HG), which received Hylan G-F 20. Evaluations were performed on treatment day (T0), 8, 15, 30, 90, and 180 days post-treatment. They consisted of four different Clinical Metrology Instruments (CMI), evaluation of weight distribution, joint range of motion, thigh girth, radiographic and digital thermography imaging, synovial fluid interleukin-1 (IL-1), and C-reactive protein concentrations. Results were compared with repeated measures ANOVA, with a Huynh-Feldt correction, Paired samples T-test, or Wilcoxon signed-ranks test, with pResults Patients had a mean age of 6.5 +/- 2.4 years and a bodyweight of 26.6 +/- 5.2kg, and joints graded as mild (n=28, 70%), moderate (n=6, 15%), and severe OA (n=6, 15%). No differences were found between groups at T0. Symmetry index and deviation showed significant improvements in HG from 30 days (p<0.01) up to 180 days (p=0.01). Several CMI scores, particularly pain scores, improved from 90 to 180 days. Radiographic signs progressed in both groups. In both groups, increasing body weight and age corresponded to worse clinical presentation. IA hyaluronan administration produced increased lameness in six cases, which resolved spontaneously. Conclusions This study characterizes the response to treatment with Hylan G-F 20, which can produce significant functional and pain level improvements in patients with OA, even those with factors related to worse response to treatment.BMCRepositório da Universidade de LisboaAlves, J. C.Moniz Pereira dos Santos, Ana MargaridaJorge, PatríciaVieira Branco Lavrador, Catarina Falcão TrigosoCarreira, L.Miguel2021-11-10T23:44:13Z2021-05-032021-05-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22541engAlves JC, dos Santos AMMP, Jorge P, Lavrador CFTVB, Carreira LM. 2021. Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial. Journal of Orthopaedic Surgery and Research, 16(1):290. DOI:10.1186/s13018-021-02423-41749-799X10.1186/s13018-021-02423-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:52:04Zoai:www.repository.utl.pt:10400.5/22541Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:06:56.707210Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
title Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
spellingShingle Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
Alves, J. C.
Animal model
Dog
Osteoarthritis
Pain
High molecular weight hyaluronan
Clinical metrology instruments
title_short Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
title_full Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
title_fullStr Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
title_full_unstemmed Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
title_sort Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model : a randomized controlled trial
author Alves, J. C.
author_facet Alves, J. C.
Moniz Pereira dos Santos, Ana Margarida
Jorge, Patrícia
Vieira Branco Lavrador, Catarina Falcão Trigoso
Carreira, L.Miguel
author_role author
author2 Moniz Pereira dos Santos, Ana Margarida
Jorge, Patrícia
Vieira Branco Lavrador, Catarina Falcão Trigoso
Carreira, L.Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Alves, J. C.
Moniz Pereira dos Santos, Ana Margarida
Jorge, Patrícia
Vieira Branco Lavrador, Catarina Falcão Trigoso
Carreira, L.Miguel
dc.subject.por.fl_str_mv Animal model
Dog
Osteoarthritis
Pain
High molecular weight hyaluronan
Clinical metrology instruments
topic Animal model
Dog
Osteoarthritis
Pain
High molecular weight hyaluronan
Clinical metrology instruments
description Research Areas: Orthopedics
publishDate 2021
dc.date.none.fl_str_mv 2021-11-10T23:44:13Z
2021-05-03
2021-05-03T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/22541
url http://hdl.handle.net/10400.5/22541
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alves JC, dos Santos AMMP, Jorge P, Lavrador CFTVB, Carreira LM. 2021. Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial. Journal of Orthopaedic Surgery and Research, 16(1):290. DOI:10.1186/s13018-021-02423-4
1749-799X
10.1186/s13018-021-02423-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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