3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.8/8363 |
Resumo: | This work was developed within the scope of the project insitu.Biomas—Reinvent biomanufacturing systems by using an usability approach for in situ clinic temporary implants fabrication, with the reference POCI-01-0247-FEDER-017771 from the Portuguese National Innovation Agency, and supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: UIDB/04044/2020, UIDP/04044/2020, PEst-OE/AGR/UI0211/2011 and PAMI—ROTEIRO/0328/2013 (Nº 022158). Mariana Vieira Branquinho (SFRH/BD/146172/2019), Ana Catarina Sousa SFRH/BD/146689/2019) and Rui Damásio Alvites (SFRH/BD/116118/2016), acknowledge the FCT for financial support. |
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3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold propertiesPolycaprolactoneHydroxyapatiteCompositesSolvent castingMelt blending3D printingCytocompatibilityBone tissue engineeringThis work was developed within the scope of the project insitu.Biomas—Reinvent biomanufacturing systems by using an usability approach for in situ clinic temporary implants fabrication, with the reference POCI-01-0247-FEDER-017771 from the Portuguese National Innovation Agency, and supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: UIDB/04044/2020, UIDP/04044/2020, PEst-OE/AGR/UI0211/2011 and PAMI—ROTEIRO/0328/2013 (Nº 022158). Mariana Vieira Branquinho (SFRH/BD/146172/2019), Ana Catarina Sousa SFRH/BD/146689/2019) and Rui Damásio Alvites (SFRH/BD/116118/2016), acknowledge the FCT for financial support.Bone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone-based scaffolds at two different proportions, 80:20 and 60:40. Scaffolds are produced with two different blending methods, solvent casting and melt blending. The prepared composites are 3D printed through an extrusion-based technique and further investigated with regard to their chemical, thermal, morphological, and mechanical characteristics. In vitro cytocompatibility and osteogenic differentiation was also assessed with human dental pulp stem/stromal cells. The results show the melt-blending-derived scaffolds to present more promising mechanical properties, along with the incorporation of hydroxyapatite. The latter is also related to an increase in osteogenic activity and promotion. Overall, this study suggests polycaprolactone/hydroxyapatite scaffolds to be promising candidates for bone tissue engineering, particularly when produced by the MB method.MDPIIC-OnlineBiscaia, SaraBranquinho, Mariana V.Alvites, Rui D.Fonseca, RitaSousa, Ana CatarinaPedrosa, Sílvia SantosCaseiro, Ana R.Guedes, FernandoPatrício, TatianaViana, TâniaMateus, ArturMaurício, Ana C.Alves, Nuno2023-04-12T12:53:57Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8363engBiscaia, S.; Branquinho, M.V.; Alvites, R.D.; Fonseca, R.; Sousa, A.C.; Pedrosa, S.S.; Caseiro, A.R.; Guedes, F.; Patrício, T.; Viana, T.; et al. 3D Printed Poly(#-caprolactone)/ Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties. Int. J. Mol. Sci. 2022, 23, 2318. https://doi.org/10.3390/ ijms230423181422-006710.3390/ ijms23042318info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:09Zoai:iconline.ipleiria.pt:10400.8/8363Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:06.007292Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| title |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| spellingShingle |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties Biscaia, Sara Polycaprolactone Hydroxyapatite Composites Solvent casting Melt blending 3D printing Cytocompatibility Bone tissue engineering |
| title_short |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| title_full |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| title_fullStr |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| title_full_unstemmed |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| title_sort |
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties |
| author |
Biscaia, Sara |
| author_facet |
Biscaia, Sara Branquinho, Mariana V. Alvites, Rui D. Fonseca, Rita Sousa, Ana Catarina Pedrosa, Sílvia Santos Caseiro, Ana R. Guedes, Fernando Patrício, Tatiana Viana, Tânia Mateus, Artur Maurício, Ana C. Alves, Nuno |
| author_role |
author |
| author2 |
Branquinho, Mariana V. Alvites, Rui D. Fonseca, Rita Sousa, Ana Catarina Pedrosa, Sílvia Santos Caseiro, Ana R. Guedes, Fernando Patrício, Tatiana Viana, Tânia Mateus, Artur Maurício, Ana C. Alves, Nuno |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
IC-Online |
| dc.contributor.author.fl_str_mv |
Biscaia, Sara Branquinho, Mariana V. Alvites, Rui D. Fonseca, Rita Sousa, Ana Catarina Pedrosa, Sílvia Santos Caseiro, Ana R. Guedes, Fernando Patrício, Tatiana Viana, Tânia Mateus, Artur Maurício, Ana C. Alves, Nuno |
| dc.subject.por.fl_str_mv |
Polycaprolactone Hydroxyapatite Composites Solvent casting Melt blending 3D printing Cytocompatibility Bone tissue engineering |
| topic |
Polycaprolactone Hydroxyapatite Composites Solvent casting Melt blending 3D printing Cytocompatibility Bone tissue engineering |
| description |
This work was developed within the scope of the project insitu.Biomas—Reinvent biomanufacturing systems by using an usability approach for in situ clinic temporary implants fabrication, with the reference POCI-01-0247-FEDER-017771 from the Portuguese National Innovation Agency, and supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: UIDB/04044/2020, UIDP/04044/2020, PEst-OE/AGR/UI0211/2011 and PAMI—ROTEIRO/0328/2013 (Nº 022158). Mariana Vieira Branquinho (SFRH/BD/146172/2019), Ana Catarina Sousa SFRH/BD/146689/2019) and Rui Damásio Alvites (SFRH/BD/116118/2016), acknowledge the FCT for financial support. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-04-12T12:53:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8363 |
| url |
http://hdl.handle.net/10400.8/8363 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Biscaia, S.; Branquinho, M.V.; Alvites, R.D.; Fonseca, R.; Sousa, A.C.; Pedrosa, S.S.; Caseiro, A.R.; Guedes, F.; Patrício, T.; Viana, T.; et al. 3D Printed Poly(#-caprolactone)/ Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties. Int. J. Mol. Sci. 2022, 23, 2318. https://doi.org/10.3390/ ijms23042318 1422-0067 10.3390/ ijms23042318 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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