Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

• Autor(a) principal: Jiang, Zhihui
• Data de Publicação: 2017
• Outros Autores: Wang, Jian, Xue, Huiting, Wang, Meng, Jiang, Hai, Liang, Yinku, Dias, Alberto Carlos Pires, Gregory, Marslin, Chen, Chen, Zhang, Xiaoying
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/51314
• topic: Corni fructus; Acute alcoholic liver; Mice; CYP2E1; Oxidative stress; Traditional Chinese medicine; Hepatoprotective drug; Hepatotoxicity; Ciências Agrárias::Biotecnologia Agrária e Alimentar; Ciências Médicas::Biotecnologia Médica; Ciências Naturais::Ciências Biológicas; Science & Technology

Background: In Chinese folk medicine, Corni fructus (C. fructus) has traditionally been used to improve liver function, although the mechanism underlying its activity remains unclear. The aim of the present study was to evaluate the protective effects of wild C. fructus methanolic extract against acute alcoholic liver injury.Methods: Alcohol was administered to mice for three consecutive days, either alone or in combination with C. fructus methanolic extract (50, 100, or 200mg/kg body weight/d). Serum and liver tissue were collected from the animals and subjected to biochemical and histopathological analyses.Results:C. fructus significantly alleviated alcohol-induced liver injury by reducing serum alanine aminotransferase, aspartate aminotransferase, and thiobarbituric acid reactive species, inhibiting hydroxyl radicals (center dot OH), and increasing total superoxide dismutase, glutathione peroxidase, and glutathione in the liver (P<0.05). In addition, the C. fructus treatment inhibited the expression and activity of cytochrome P450 2E1 (P<0.05)Conclusions:C. fructus could be a promising natural substance for ameliorating acute alcohol-induced oxidative stress and hepatic injury.